Results 101 to 110 of about 336,238 (316)

Genipin‐Crosslinked, Silane‐Anchored 3D Tumor–Stroma Microtissues for High‐Content On‐Chip Drug Testing

Advanced Healthcare Materials, EarlyView.
We describe a microfluidic tumor‐stroma co‐culture model, engineered to resist collagen‐hydrogel contraction driven by fibroblast activity. Surface silanization with APTES covalently anchors the matrix to the chip, while Genipin crosslinking progressively increases stiffness and elasticity without harming cells. This supports >10 days of co‐culture and
Doriane Le Manach, Reza Kowsari‐Esfahan, Emilia Reszczyńska, Philippe Nghe, Matthias Nees   +4 more
wiley   +1 more source

Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis [PDF]

, 2017
Healthy individuals of African ancestry have neutropenia that has been linked with the variant rs2814778(G) of the gene encoding atypical chemokine receptor 1 (ACKR1).
Megens, Remco T. A., Artinger, K., Duchene, Johan, Rot, Antal, Rot, A, Bianchini, Mariaelvy, von Andrian, Ulrich H., Caamano, J., von Andrian, UH, Aude Thiriot, Weber, Christian, Thiriot, Aude, Casanova-Acebes, M., Weber, C, Johan Duchene, S Leah Etheridge, Casanova-Acebes, Maria, Rot, A., Caamano, J, Megens, RTA, Nitz, K., Remco T A Megens, Moss, Paul; id_orcid, Eller, Kathrin, Etheridge, S.L., von Andrian, U.H., Hidalgo, A., Hub, E, Moss, Paul, Duchene, J, Megens, R.T.A., Ulrich H von Andrian, Hidalgo, Andres, Etheridge, SL, Duchene, J., Bianchini, M, Hub, E., Antal Rot, Thiriot, A., Thiriot, A, Igor Novitzky-Basso, Maria Casanova-Acebes, Artinger, K, Thomas Rülicke, Caamaño, Jorge; id_orcid, Moss, P., Jorge Caamaño, Hidalgo, A, von Andrian-Werburg, Ulrich, Eller, K, Artinger, Katharina, Moss, P, Bianchini, M., Mariaelvy Bianchini, Andres Hidalgo, Weber, C., Katharina Artinger, Casanova-Acebes, M, Novitzky-Basso, I., Rulicke, Thomas, Rulicke, T, Etheridge, S Leah, Megens, Remco T A, Etheridge, S. Leah, Caamano, Jorge, Novitzky-Basso, I, Katrin Nitz, Eller, K., Ruelicke, T., Hub, Elin, Von Andrian, Ulrich H, Kathrin Eller, Paul Moss, Nitz, Katrin, Nitz, K, Novitzky-Basso, Igor, Elin Hub, Christian Weber   +77 more
core   +1 more source

An Autocrine Wnt5a Loop Promotes NF-κB Pathway Activation and Cytokine/Chemokine Secretion in Melanoma

Cells, 2019
Wnt5a signaling has been implicated in the progression of cancer by regulating multiple cellular processes, largely migration and invasion, epithelial-mesenchymal transition (EMT), and metastasis.
Gastón Barbero, María Victoria Castro, María Belén Villanueva, María Josefina Quezada, Natalia Brenda Fernández, Sharon DeMorrow, Pablo Lopez-Bergami   +6 more
doaj   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Immunoinflammatory Mechanisms and Biocompatibility of Bioactive Dental Biomaterials: From Fundamental Insights to Clinical Translation

Advanced Healthcare Materials, EarlyView.
Surface‐host dialogue at the implant interface governs biological fate and osseointegration. Surface physicochemical properties of titanium (Ti) dental implants, including microgrooves, nanopatterns, nanotopography, roughness, and wettability, modulate the initial adsorption of proteins and the formation of a dynamic biointerface.
Daniela Moreira Cunha, Amanda Paino Santana, Marta Maria Alves Pereira, Mariana Martins Guerreiro, Jose Mauro Granjeiro, Jamil Awad Shibli, Jeroen J. J. P. van den Beucken, Anton Sculean, Rafael Scaf de Molon, Erica Dorigatti de Avila   +9 more
wiley   +1 more source

The role of the chemokine receptor CXCR4 in oral squamous cell carcinoma metastasis

, 2010
PhDOral Squamous Cell Carcinoma (OSCC) is the sixth most common cancer worldwide. The greatest cause of mortality and surgical morbidity is due to the common spread of tumour cells from the primary lesion to the lymph nodes of the neck. This pathway is
Collier, Jonathan Marc
core  

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

C-C Chemokine Receptor 5 and HIV: Therapeutic Potentials of the Δ32 Base Pair Deletion

, 2011
The human immunodeficiency virus, a retrovirus discovered in 1981, has reached pandemic status worldwide. Without an existing cure or vaccine, a majority of the world’s population remains at risk for infection and more than 35 million people to date have
Antczak, Amanda R.
core  

Enhanced expression of cytokines/chemokines in cerebrospinal fluids in mumps meningitis in children

, 2011
ArticleBackground: The mumps virus is frequently the causative agent in aseptic meningitis and mumps has still prevailed in Japan. We compared data obtained from patients with mumps meningitis and patients with aseptic meningitis caused by other viruses ...
9399, Mashiko, Kunihiro, 9400, 9397, Sakamoto, Yuichiro, Kaizu, Kiyohiko, 9398, 9403, 9401, 9402, Hatori, Takayuki, 9395, 9396, Asano, Takeshi, 9394, Koizumi, Shinya, Ichiki, Kunihiko, Fukunaga, Yoshitaka, Miyasho, Taku, Fujino, Osamu   +19 more
core   +1 more source

The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease

Respiratory Research, 2001
The lung responds to a variety of insults in a remarkably consistent fashion but with inconsistent outcomes that vary from complete resolution and return to normal to the destruction of normal architecture and progressive fibrosis.
Keane Michael P, Strieter Robert M
doaj   +1 more source