Results 81 to 90 of about 498,931 (351)

Arrest Chemokines [PDF]

Frontiers in Immunology, 2003
ABSTRACTIn most organs, leukocyte attachment to the endothelium of blood vessels requires capture and rolling before firm adhesion is initiated by integrin activation and/or redistribution, which can be initiated by immobilized chemokines binding their cognate receptors on rolling cells.
openaire   +5 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes

, 2009
<p>Interleukin 17 (IL-17) is a proinflammatory cytokine, produced only by activated lymphocytes, but with a broad cellular host range. The effects of IL-17 on fibroblasts were investigated by analysis of the induction of chemokine and matrix ...
J. Hu, Zheng Qiu, Ghislain Opdenakker, Sofie Struyf, Jo Van Damme, G. Opdenakker, Chris Dillen, C. Dillen, Jialiang Hu, J. Van Damme, Hannelien Verbeke, S. Struyf, H. Verbeke, Z. Qiu   +13 more
core   +1 more source

Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis [PDF]

, 2009
Introduction Chemokines and their receptors control immune cell migration during infections as well as in autoimmune responses. A 32 bp deletion in the gene of the chemokine receptor CCR5 confers protection against HIV infection, but has also been ...
Rossol, Manuela, Keyßer, Gernot, Baerwald, Christoph, Burkhardt, Harald, Pierer, Matthias, Arnold, Sybille, Wagner, Ulf   +6 more
core   +1 more source

Sulforaphane ameliorates non-alcoholic steatohepatitis by KLF4-mediated macrophage M2 polarization

Food Science and Human Wellness
Non-alcoholic fatty liver disease (NAFLD) has become a global issue and a severe threat to public health. However, to date, no approved therapeutic drugs have been developed.
Xianghui Huang, Jia Xu, Ye Xu, Bingxin Huangfu, Feng Zhang, Yanzhou Hu, Ruxin Gao, Xinxin Ren, Boyang Zhang, Kunlun Huang, Xiaoyun He   +10 more
doaj   +1 more source

Chimeric Oncolytic Adenovirus Armed Chemokine Rantes for Treatment of Breast Cancer

Bioengineering, 2022
The immunosuppressive state in the tumor microenvironment (TME) of breast cancer makes it difficult to treat with immunotherapy. Oncolytic viruses not only lyse tumor cells but also reshape the TME.
Lin Ang, Jiang Li, Hui Dong, Chunhong Wang, Jin Huang, Mingcong Li, Min Zhao, Changqing Su, Qiang Wu   +8 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Monocytes/macrophages express CCR9 in rheumatoid arthritis and CCL25 stimulates their differentiation [PDF]

, 2010
Introduction: Monocytes/macrophages accumulate in the rheumatoid (RA) synovium where they play a central role in inflammation and joint destruction. Identification of molecules involved in their accumulation and differentiation is important to inform ...
Buckley, Christopher, Helen Williams, Cartwright, A, John HH Williams, Andrew Filer, Schmutz, Caroline, Oliver Haworth, Filer, Andrew, Mike Salmon, Haworth, O, Buckley, Christopher D., Alison Cartwright, Christopher D Buckley, Schmutz, C, Williams, John H. H., Middleton, J, Haworth, Oliver, Buckley, CD, Williams, JH, Cartwright, Alison, Caroline Schmutz, Williams, HJ, Middleton, Jim F., Williams, Helen, Salmon, Mike, Filer, A, Salmon, M, Williams, J, Williams, H, Middleton, Jim F S, Jim Middleton   +30 more
core   +1 more source

Role of Cytokines, Chemokines and IFN-γ⁺ IL-17⁺ Double-Positive CD4⁺ T Cells in Patients with Multiple Sclerosis

Biomedicines, 2022
Multiple sclerosis is mediated by self-reactive myelin T and B cells that lead to axonal and myelin damage. The immune response in multiple sclerosis involves the participation of CD4+ T cells that produce cytokines and chemokines.
Marlos Aureliano Dias de Sousa, Chamberttan Souza Desidério, Jonatas da Silva Catarino, Rafael Obata Trevisan, Djalma Alexandre Alves da Silva, Vinicius Ferreira Resende Rocha, Weslley Guimarães Bovi, Rodolfo Pessato Timoteo, Renata Cristina Franzon Bonatti, Alex Eduardo da Silva, Alfredo Leboreiro Fernandez, Helioswilton Sales-Campos, Virmondes Rodrigues Junior, Marcos Vinicius da Silva, Carlo José Freire de Oliveira   +14 more
doaj   +1 more source

A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.

Cell, 1996
Here, we show that the beta-chemokine receptor CKR-5 serves as a cofactor for M-tropic HIV viruses. Expression of CKR-5 with CD4 enables nonpermissive cells to form syncytia with cells expressing M-tropic, but not T-tropic, HIV-1 env proteins. Expression
B. Doranz, Joseph B. Rucker, Y. Yi, R. Smyth, M. Samson, S. Peiper, M. Parmentier, R. Collman, R. Doms   +8 more
semanticscholar   +1 more source