Results 81 to 90 of about 468,477 (308)

Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis [PDF]

, 2018
Inflammatory illness is associated with depression. Preclinical work has shown that chemokines are linked with peripheral–central crosstalk and may be important in mediating depressive behaviours.
Cavanagh, J., Graham, G.J., Johnman, C., Krishnadas, R., Leighton, S.P., Nerurkar, L.   +5 more
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Role of Cytokines, Chemokines and IFN-γ⁺ IL-17⁺ Double-Positive CD4⁺ T Cells in Patients with Multiple Sclerosis

Biomedicines, 2022
Multiple sclerosis is mediated by self-reactive myelin T and B cells that lead to axonal and myelin damage. The immune response in multiple sclerosis involves the participation of CD4+ T cells that produce cytokines and chemokines.
Marlos Aureliano Dias de Sousa, Chamberttan Souza Desidério, Jonatas da Silva Catarino, Rafael Obata Trevisan, Djalma Alexandre Alves da Silva, Vinicius Ferreira Resende Rocha, Weslley Guimarães Bovi, Rodolfo Pessato Timoteo, Renata Cristina Franzon Bonatti, Alex Eduardo da Silva, Alfredo Leboreiro Fernandez, Helioswilton Sales-Campos, Virmondes Rodrigues Junior, Marcos Vinicius da Silva, Carlo José Freire de Oliveira   +14 more
doaj   +1 more source

The Effect of N-Terminal Cyclization on the Function of the HIV Entry Inhibitor 5P12-RANTES. [PDF]

, 2017
Despite effective treatment for those living with Human Immunodeficiency Virus (HIV), there are still two million new infections each year. Protein-based HIV entry inhibitors, being highly effective and specific, could be used to protect people from ...
F Nguyen, Anna, J LiWang, Patricia, Jian, Mike, S Schill, Megan   +3 more
core   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The levels of circulating cytokines and risk of neuromyelitis optica spectrum disorder: a Mendelian randomization study

Frontiers in Immunology
BackgroundNeuromyelitis optica spectrum disorder (NMOSD) is an inflammatory autoimmune disease affecting the central nervous system (CNS). NMOSD pathogenesis involves systemic inflammation.
Xue Ma, Xue Ma, Yao Wang, Xin Chen, Jun Guo   +4 more
doaj   +1 more source

Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression

OncoImmunology, 2017
Immune checkpoint inhibitors have significantly improved the treatment of several cancers. T-cell infiltration and the number of neoantigens caused by tumor-specific mutations are correlated to favorable responses in cancers with a high mutation load ...
Julian P. Layer, Marie T. Kronmüller, Thomas Quast, Debby van den Boorn-Konijnenberg, Maike Effern, Daniel Hinze, Kristina Althoff, Alexander Schramm, Frank Westermann, Martin Peifer, Gunther Hartmann, Thomas Tüting, Waldemar Kolanus, Matthias Fischer, Johannes Schulte, Michael Hölzel   +15 more
doaj   +1 more source

Src as the link between inflammation and cancer. [PDF]

, 2013
Although a causal link between chronic inflammation and cancer has been established, the exact molecular mechanism linking inflammation to cancer remains largely unknown.
Andrzej ePtasznik, Hung ePham, Sandy eLiu, Stephen J Pandol, Stephen J Pandol   +4 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Association of the SNPs in CCL2 and CXCL12 genes with the susceptibility to breast cancer: a case-control study in China

Frontiers in Oncology
BackgroundChemokines are well-known for playing an essential role in the development of cancer. However, the association between SNPs in the CCL2 and CXCL12 genes and the susceptibility to breast cancer remains unclear.MethodsA case-control study was ...
Duanchong Zhao, Xingxing Yu, Hongli Huang, Shuqing Zou, Pingxiu Zhu, Yuxiang Lin, Yuxiang Lin, Mengjie Song, Fangmeng Fu, Fangmeng Fu, Haomin Yang, Haomin Yang   +11 more
doaj   +1 more source