Results 91 to 100 of about 498,931 (351)

Chemokines, chemokine receptors, and cancer metastasis [PDF]

Journal of Leukocyte Biology, 2006
Abstract It is clear from large clinical studies that selected chemokine receptors are often up-regulated in a large number of common human cancers, including those of the breast, lung, prostate, colon, and melanoma. Chemokine receptors and their corresponding chemokine ligands have been demonstrated to play a number of nonredundant ...
Takashi, Kakinuma, Sam T, Hwang
openaire   +2 more sources

Chemokines and chemokine receptors in Behçet’s disease

Frontiers in Immunology, 2023
Behçet’s disease (BD), a chronic vascular inflammatory disease, is characterized by the symptoms of ocular lesions, recurrent genital and oral ulcers, skin symptoms and arthritis in addition to neurological, intestinal and vascular involvement. The pathogenesis of BD is poorly understood, and there are no effective laboratory markers for the diagnosis ...
Zhan Li, Zhan Li, Linlin Cheng, Linlin Cheng, Haoting Zhan, Haoting Zhan, Yongzhe Li, Yongzhe Li   +7 more
openaire   +3 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Chemokine-induced secretion of gelatinase B in primary human monocytes [PDF]

, 2001
Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited ...
Nelson, EL, Nelson, P. J., Schlöndorff, D, C.D. Cohen, D. Schlöndorff, C.M. Klier, Horuk, R, P.J. Nelson, Schlöndorff, D., Klier, C. M., E.L. Nelson, Nelson, PJ, Cohen, CD, Horuk, R., Cohen, C. D., R. Horuk, Klier, CM, Nelson, E. L.   +17 more
core   +1 more source

The levels of circulating cytokines and risk of neuromyelitis optica spectrum disorder: a Mendelian randomization study

Frontiers in Immunology
BackgroundNeuromyelitis optica spectrum disorder (NMOSD) is an inflammatory autoimmune disease affecting the central nervous system (CNS). NMOSD pathogenesis involves systemic inflammation.
Xue Ma, Xue Ma, Yao Wang, Xin Chen, Jun Guo   +4 more
doaj   +1 more source

Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression

OncoImmunology, 2017
Immune checkpoint inhibitors have significantly improved the treatment of several cancers. T-cell infiltration and the number of neoantigens caused by tumor-specific mutations are correlated to favorable responses in cancers with a high mutation load ...
Julian P. Layer, Marie T. Kronmüller, Thomas Quast, Debby van den Boorn-Konijnenberg, Maike Effern, Daniel Hinze, Kristina Althoff, Alexander Schramm, Frank Westermann, Martin Peifer, Gunther Hartmann, Thomas Tüting, Waldemar Kolanus, Matthias Fischer, Johannes Schulte, Michael Hölzel   +15 more
doaj   +1 more source

Virus-Derived Chemokine Modulating Protein Pre-Treatment Blocks Chemokine–Glycosaminoglycan Interactions and Significantly Reduces Transplant Immune Damage

Pathogens, 2022
Immune cell invasion after the transplantation of solid organs is directed by chemokines binding to glycosaminoglycans (GAGs), creating gradients that guide immune cell infiltration. Renal transplant is the preferred treatment for end stage renal failure,
Isabela R. Zanetti, Michelle Burgin, Liqiang Zhang, Steve T. Yeh, Sriram Ambadapadi, Jacquelyn Kilbourne, Jordan R. Yaron, Kenneth M. Lowe, Juliane Daggett-Vondras, David Fonseca, Ryan Boyd, Dara Wakefield, William Clapp, Efrem Lim, Hao Chen, Alexandra Lucas   +15 more
doaj   +1 more source

Regulation of Atherogenesis by Chemokines and Chemokine Receptors [PDF]

Archivum Immunologiae et Therapiae Experimentalis, 2012
Atherosclerosis is a chronic inflammatory and metabolic disorder affecting large- and medium-sized arteries, and the leading cause of mortality worldwide. The pathogenesis of atherosclerosis involves accumulation of lipids and leukocytes in the intima of blood vessel walls creating plaque.
Wuzhou, Wan, Philip M, Murphy
openaire   +2 more sources

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Association of the SNPs in CCL2 and CXCL12 genes with the susceptibility to breast cancer: a case-control study in China

Frontiers in Oncology
BackgroundChemokines are well-known for playing an essential role in the development of cancer. However, the association between SNPs in the CCL2 and CXCL12 genes and the susceptibility to breast cancer remains unclear.MethodsA case-control study was ...
Duanchong Zhao, Xingxing Yu, Hongli Huang, Shuqing Zou, Pingxiu Zhu, Yuxiang Lin, Yuxiang Lin, Mengjie Song, Fangmeng Fu, Fangmeng Fu, Haomin Yang, Haomin Yang   +11 more
doaj   +1 more source