Results 251 to 260 of about 336,238 (316)

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity

Advanced Science, EarlyView.
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen, Zhao‐Yu Liu, Gao‐Wen Qu, Run‐Hao Zeng, Wen‐Xia Yao, Yong‐Bing Zhou, Xue Liang, Yu‐Xiong Lai   +7 more
wiley   +1 more source

Reprogramming of stroma-derived chemokine networks drives the loss of tissue organization in nodal B cell lymphoma. [PDF]

Nat Cancer
Czernilofsky F, Mathioudaki A, Jopp-Saile L, Lutz R, Vonficht D, Wang X, Schniederjohann C, Voehringer H, Roider T, Baertsch MA, Rodemer C, Löffler-Wirth H, Grau M, Fitzgerald D, Mammen J, Kosla J, Liebers N, Bruch PM, Ordoñez-Rueda D, Brobeil A, Mechtersheimer G, Pabst C, Müller-Tidow C, Trumpp A, Seifert M, Neumann F, Heikenwälder M, Benes V, Huber W, Distler J, Lenz G, Binder H, Siebert R, Nolan GP, Gerstung M, Zaugg JB, Hübschmann D, Haas S, Dietrich S.   +38 more
europepmc   +1 more source

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source

Membrane-anchored chemokine fusion proteins as adjuvants for tumor therapy [PDF]

, 2012
Münchmeier, Jan Niklas
core  

The Innate and Adaptive Immune Functions of Osteoblast-Lineage Cells. [PDF]

Curr Osteoporos Rep
Hossain MA, Hurtado PR, Atkins GJ.
europepmc   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Restriction of HSV-1 replication by Pistacia vera L. extracts reveals a promising strategy for regulating virus-mediated chemokine response in monocytic cells. [PDF]

Sci Rep
Pennisi R, Costa M, Tamburello MP, Trischitta P, Mandalari G, Sciortino MT.   +5 more
europepmc   +1 more source

Unveiling post-vaccination proteomic signatures in SARS-CoV-2 infection-naïve individuals associated with Omicron breakthrough infections. [PDF]

PLoS One
Liu Y, Lu E, Ellingson KD, Hollister J, Liu T, Hamzazai W, Beitel SC, Caban-Martinez AJ, Gaglani M, Naleway AL, Olsho LEW, Phillips AL, Solle NS, Tyner HL, Yoon SK, Lutrick K, Burgess JL.   +16 more
europepmc   +1 more source

Serum and CSF cytokine profile impact clinical phenotype in pediatric MOGAD. [PDF]

J Neuroinflammation
Ohashi E, Kohyama K, Mori T, Matsuda S, Nishida H, Miyama S, Hayakawa I, Abe Y, Yamada N, Suzuki M, Matsubara K, Fukuoka M, Inoue T, Kuki I, Sakuma H.   +14 more
europepmc   +1 more source

Single Cell and Bulk RNA-Seq Profiling of Non-Metastatic Versus Bone-Metastatic Prostate Cancer Identifies the CXCL10-CXCR3 Axis as a Key Determinant of Tumor Microenvironment and Treatment Resistance. [PDF]

Biomedicines
Song Z, Ren L, Wang H, Wang Y, Du X, Zhou W, Zhang Q, Yu J, Zhao Z, Ye L, Jin K, Liu Y, Xue W.   +12 more
europepmc   +1 more source