Results 131 to 140 of about 63,435 (292)

The Chemokine CCL2 Protects Against Methylmercury Neurotoxicity

, 2017
Industrial pollution due to heavy metals such as mercury is a major concern for the environment and public health. Mercury, in particular methylmercury (MeHg), primarily affects brain development and neuronal activity, resulting in neurotoxic effects ...
Laclau, Muriel, Godefroy, David, Maury-Brachet, Régine, Combadière, Christophe, Rakwal, Randeep, Bourdineaud, Jean-Paul, Gosselin, Romain-Daniel, Melik-Parsadaniantz, Stéphane, Yasutake, Akira, Fujimura, Masatake, Rostène, William   +10 more
core  

Chemokine CCL2 Mediates Neuroglial Crosstalk and Drives Chronic Pain Pathogenesis

Neuroscience Bulletin
Chronic pain, frequently comorbid with neuropsychiatric disorders, significantly impairs patients' quality of life and functional capacity. Accumulating evidence implicates the chemokine CCL2 and its receptor CCR2 as key players in chronic pain pathogenesis. This review examines the regulatory mechanisms of the CCL2/CCR2 axis in chronic pain processing
Junyu Lu, Yunxin Shi, Yongkang Li, Ziyi Niu, Shengxi Wu, Ceng Luo, Rou-Gang Xie   +6 more
openaire   +3 more sources

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source

Purification of recombinant human chemokine CCL2 in E. coli and its function in ovarian cancer. [PDF]

3 Biotech, 2021
Liu W, Wang L, Zhang J, Qiao L, Liu Y, Yang X, Zhang J, Zheng W, Ma Z.   +8 more
europepmc   +1 more source

CCL2 binding is CCR2 independent in primary adult human astrocytes.

, 2012
Chemokines are low relative molecular mass proteins, which have chemoattractant actions on many cell types. The chemokine, CCL2, has been shown to play a major role in the recruitment of monocytes in central nervous system (CNS) lesions in multiple ...
Woodroofe, M. N., Fouillet, A., I.A. Romero, Sharrack, B., Woodroofe, Nicola Woodroofe, A. Fouillet, Suliman, O, Mawson, J., Suliman, O., O. Suliman, B. Sharrack, Sharrack, B, J. Mawson, Fouillet, A, Romero, I. A., Romero, I A, M.N. Woodroofe, Mawson, J   +17 more
core   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

HCV Core Protein Induces Chemokine CCL2 and CXCL10 Expression Through NF-κB Signaling Pathway in Macrophages. [PDF]

Front Immunol, 2021
Song X, Gao X, Wang Y, Raja R, Zhang Y, Yang S, Li M, Yao Z, Wei L.   +8 more
europepmc   +1 more source

Human Urine Stem Cells Alleviate Pulmonary Fibrosis via Inhibiting Macrophage‐Myofibroblast Transition

Advanced Science, EarlyView.
Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang, Guan‐Lin Guo, Xiao‐Hui Guan, Min Hu, Qi‐Ming Huang, Ding‐Wen Guo, Hao‐Cheng Gu, You‐Qiong Zhuo, Ning Li, Hong‐Bo Xin, Ke‐Yu Deng   +10 more
wiley   +1 more source

Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity. [PDF]

J Neuroinflammation, 2021
Dansereau MA, Midavaine É, Bégin-Lavallée V, Belkouch M, Beaudet N, Longpré JM, Mélik-Parsadaniantz S, Sarret P.   +7 more
europepmc   +1 more source

Funktion der Chemokine CCL2 und CCL3 in einem experimentellen Tiermodell zur Multiplen Sklerose

, 2019
Multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system (CNS). In fundamental MS research, the cuprizone mouse model is a commonly used animal model that allows the - still not fully explained - complex cellular,
Schlesinger, Mira Katharina
core   +1 more source