Results 161 to 170 of about 59,942 (256)

Impact of sleep insufficiency and recovery on cancer development

Sleep Research, EarlyView.
Abstract Sleep plays a critical role in overall health, and modern lifestyles, such as shift work and late‐night activities, can significantly impact sleep condition. Insufficient sleep has been associated with various adverse health outcomes, including an increased risk of tumor development.
Xiaxi Li, Chuanyuan Li, Yi Zhang
wiley   +1 more source

Progress in bone tissue engineering biomaterials: Development, challenges, and prospects

VIEW, EarlyView.
Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang, Junlei Chai, Quanwei Ding, Luping Liu, Kejie Zhang, Jie Lin, Jianhua Zhang, Youju Huang   +7 more
wiley   +1 more source

Elevated CO2 and Temperature Alter Grass Pollen's Ability to Modify Transcriptome and Function of the Nasal Epithelium

Allergy, EarlyView.
We exposed human nasal epithelial tissues to pollen from grasses grown under different climate treatments (temperature and CO2). Pollen weakened epithelial tight junctions and altered cytokine‐related gene expression, with similar protein‐level effects.
Tarleena Tossavainen, Tanja Turunen, Maria‐Viola Martikainen, Miisa Kankaanpää, Marjo Malinen, Marjut Roponen   +5 more
wiley   +1 more source

CC chemokines CCL2, CCL3, CCL4 and CCL5 are elevated in osteoporosis patients

The Journal of Biomedical Research, 2017
Farangis, Fatehi, Majid, Mollahosseini, Gholamhossein, Hassanshahi, Soudeh Khanamani, Falahati-pour, Hossein, Khorramdelazad, Zahra, Ahmadi, Mojgan, Noroozi Karimabad, Habib, Farahmand   +7 more
openaire   +2 more sources

IL‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways

Allergy, EarlyView.
IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama, Jun Miyata, Takao Mochimaru, Ryuta Onozato, Yo Otsu, Hisashi Sasaki, Keeya Sunata, Shinichi Okuzumi, Katsunori Masaki, Hiroki Kabata, Keinosuke Hizuka, Yoshinori Hasegawa, Ryo Konno, Yusuke Kawashima, Makoto Arita, Shigeharu Ueki, Koichi Fukunaga   +16 more
wiley   +1 more source

Distinct Immunometabolic Profiles in Finnish and Russian Karelian Adolescents With Contrasting Allergy Risk

Allergy, EarlyView.
We compared Finnish and Russian Karelian adolescents with contrasting allergy burden using integrated proteomic, metabolomic, and transcriptomic profiling. Finnish adolescents showed a broader pro‐inflammatory PBMC secretory profile consistent with a low‐grade inflammatory phenotype.
Nanna Fyhrquist, Matilda Riskumäki, Piia Karisola, Anni Nieminen, Tiina Laatikainen, Hanna Sinkko, Laura Paalanen, Pekka Jousilahti, Erkki Vartiainen, Mika J. Mäkelä, Tari Haahtela, Harri Alenius   +11 more
wiley   +1 more source

Distinct Gene Expression Profiles of Ara h 2‐Specific B Cells in Desensitization and Tolerance During Peanut Oral Immunotherapy

Allergy, EarlyView.
Gene expression of Ara h 2‐specific B cells over the course of the peanut OIT. Isotype of allergen‐specific B cells changes through OIT towards IgG4. Peanut OIT changes the gene expression of allergen‐specific memory B cells. OIT patients showed increased gene expression for regulatory B cells and immune regulation.
Stephan R. Schneider, Juan‐Felipe López, Huseyn Babayev, Willem van de Veen, Minglin Yang, Cezmi A. Akdis, Kari Nadeau, Carolyn H. Baloh, Stacie M. Jones, Lisa M. Wheatley, Mübeccel Akdis, IMPACT, Amy M. Scurlock, D. Pesek, Joy Laurienzo‐Panza, Marshall Plaut, A. Wesley Burks, Edwin H. Kim, Mike Kulis, Anna Nowak‐Wegrzyn, Hugh A. Sampson, Julie Wang, Robert A. Wood, Sharon Chinthrajah, Robert Sayantani B. Sindher, Jacqueline Johnson, Katharine Spain, Denise C. Babineau, Hyunsook Chin, Rachel Yan, Don Whitehouse, Michelle L. Sever, Srinath Sanda, David Larson, Tielin Qin, Gina Marchesini, Kavitha Gilroy, Sylvia Posso, Sabrina Skiba, Thien‐Son Nguyen, Adam Wojno, Tuan Nguyen, Vivian Gersuk, Quynh‐Anh Nguyen, Jessica Garber, Kimberly O'Brien, Brandon Larson, C. Cousens‐Jacobs, Alex Hu   +48 more
wiley   +1 more source

Common Food Emulsifiers Impair Epithelial Barrier Integrity and Trigger Pro‐Inflammatory Responses and IgE Production

Allergy, EarlyView.
Soy lecithin and DATEM, the two commonly used food emulsifiers introduced into many foods including peanut butter and puffed bread, in the 2000s, impair intestinal epithelial barrier integrity in human gut‐on‐a‐chip and induced pluripotent stem cell colon organoid models.
Duygu Yazici, Yuka Hayashi, Yagiz Pat, Jennifer Hotie, Mehmet Ali Balci, Sena Ardicli, Juan Felipe Lopez, Ozge Ardicli, Bingjie Zhao, Angel Maldonado, Can Zeyneloglu, Kenji Matsumoto, Manru Li, Beate Rückhert, Lihong Chang, Ismail Ogulur, Vahap Eldem, Raja Dhir, Mubeccel Akdis, Kari Nadeau, Oscar Palomares, Hideaki Morita, Cezmi A. Akdis   +22 more
wiley   +1 more source

Artemisinin-Related Therapeutic Strategies for Autoimmune Thyroiditis: Chemokine-Receptor Networks, Spatial Thyroid Biology, and Molecular Mechanisms. [PDF]

Drug Des Devel Ther
Sun Y, Yang X, Zhu Q, Yang R.
europepmc   +1 more source

The immunological landscape of the area postrema in neuromyelitis optica spectrum disorders

Brain Pathology, EarlyView.
Aquaporin‐4 antibody‐positive neuromyelitis spectrum disorder is characterized by large tissue destructive lesions in medulla, spinal cord, and optic nerves, with only partial recovery from clinical symptoms, and by lesions with very little tissue destruction and mostly complete recovery from clinical symptoms, as seen in the area postrema ...
Qian Yu, Yoshiki Takai, Naoya Yamazaki, Sarah Brandl, Katharina M. Mair, Thibault Bouderlique, Maria Eleni Kastriti, Igor Adameyko, Romana Höftberger, Markus Reindl, Jan Bauer, Monika Bradl   +11 more
wiley   +1 more source