Results 221 to 230 of about 59,942 (256)
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Chemokine CCL2 and chemokine receptor CCR2 in early active multiple sclerosis
European Journal of Neurology, 2004The chemokine monocyte chemoattractant protein (MCP)‐1/CCL2 and its receptor CCR2 have been strongly implicated in disease pathogenesis in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis (MS), whereas data on the CCL2–CCR2 axis are scarce in MS.
Torben Lykke Sørensen
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Experimental Eye Research, 2013 Monocytes, macrophages, dendritic cells and microglia play critical roles in the local immune response to acute and chronic tissue injury and have been implicated in the pathogenesis of age-related macular degeneration. Defects in Ccl2-Ccr2 and Cx3cl1-Cx3cr1 chemokine signalling cause enhanced accumulation of bloated subretinal microglia/macrophages in
Peter Munro +2 more
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The multifaceted roles of the chemokines CCL2 and CXCL12 in osteophilic metastatic cancers
Cancer and Metastasis Reviews, 2021Breast and prostate cancers have a great propensity to metastasize to long bones. The development of bone metastases is life-threatening, incurable, and drastically reduces patients' quality of life. The chemokines CCL2 and CXCL12 and their respective receptors, CCR2 and CXCR4, are central instigators involved in all stages leading to cancer cell ...
Élora Midavaine +2 more
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The inflammatory chemokines CCL2 and CCL5 in breast cancer
Cancer Letters, 2008A causal role was recently attributed to inflammation in many malignant diseases, including breast cancer. The different inflammatory mediators that are involved in this disease include cells, cytokines and chemokines. Of these, many studies have addressed the involvement and roles of the inflammatory chemokines CCL2 (MCP-1) and CCL5 (RANTES) in breast
Gali, Soria, Adit, Ben-Baruch
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Increase of CXC chemokine CXCL10 and CC chemokine CCL2 serum levels in normal ageing
Cytokine, 2006No study has evaluated contemporaneously serum CXC and CC chemokines changes in normal ageing. Serum levels of CXCL10 (sCXCL10) (CXC) and CCL2 (sCCL2) (CC) prototype chemokines have been measured in 164 healthy subjects, from 10 to 79 years of age (82 males/82 females).
Mario Rotondi +2 more
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Dissecting the differential structural and dynamics features of CCL2 chemokine orthologs
International Journal of Biological Macromolecules, 2020Chemokines are a sub-group of cytokines that regulate the leukocyte migration. Monocyte chemoattractant protein-1 (MCP/CCL2) is one of the essential CC chemokine that regulates the migration of monocytes into inflamed tissues. It has been observed that the primary sequences of CCL2 orthologs among rodents and primates vary significantly at the C ...
Nidhi, Joshi +6 more
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Chemokine CCL2 Induces Apoptosis in Cortex Following Traumatic Brain Injury
Journal of Molecular Neuroscience, 2013The chemokine C-C motif ligand 2 (CCL2) is an important mediator of neuroinflammation. Released in response to acute injury, ischemia, and neurodegenerative disease, CCL2 binds primarily to the G-protein-coupled chemokine C-C motif receptor 2 (CCR2) to recruit inflammatory cells to sites of tissue damage. Inflammation is thought to have both beneficial
Lixia Zhang, Su Liu, Qinfeng Wu
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2021
Curcumin, as a vegetative flavonoid, has a protective and therapeutic role in various adverse states such as oxidative stress and inflammation. Remedial properties of this component have been reported in the different chronic diseases including cancers (myeloma, pancreatic, breast, colorectal), vitiligo, psoriasis, neuropathic pains, inflammatory ...
Mahdiyeh, Hedayati-Moghadam +7 more
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Curcumin, as a vegetative flavonoid, has a protective and therapeutic role in various adverse states such as oxidative stress and inflammation. Remedial properties of this component have been reported in the different chronic diseases including cancers (myeloma, pancreatic, breast, colorectal), vitiligo, psoriasis, neuropathic pains, inflammatory ...
Mahdiyeh, Hedayati-Moghadam +7 more
openaire +2 more sources