Results 231 to 240 of about 59,942 (256)

Serum α-Chemokine CXCL10 and β-Chemokine CCL2 Levels in HCV-Positive Cryoglobulinemia

2011
Chemokines are a group of low-molecular-weight peptides that induce the recruitment of leukocytes to sites of inflammation. Among the four major families, CXC chemokines, with CXCL10 as the prototype, display a strong chemo-attractant activity for Th1 lymphocytes and is a reliable marker of Th1-immune mediated diseases.
ANTONELLI, ALESSANDRO, Ferri C, Ferrari SM, Colaci M, Ruffilli I, Mancusi C, FERRANNINI, ELEUTERIO, Fallahi P.   +7 more
openaire   +1 more source

Proinflammatory cytokines modulate the chemokine CCL2 (MCP-1) in human annulus cells in vitro: CCL2 expression and production

Experimental and Molecular Pathology, 2015
Chemokines are important secondary inflammatory mediators released in response to stimuli which act as second-order cytokines with specialized functions in inflammation. The role of many of these specialized mediators is as yet poorly understood in the human intervertebral disc.
Michael Cox, Edward N Hanley, Jane A Ingram   +2 more
exaly   +3 more sources

Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases

Archives of Pharmacal Research, 2013
Chemokines are members of the chemoattractant cytokine family. They play key roles in the trafficking of leukocytes and in the induction of chemotaxis through the activation of G protein-coupled receptor. Considerable interest has been paid to these molecules to elucidate their roles in the unique inflammatory responses elicited in the central nervous ...
Shambhunath, Bose, Jungsook, Cho
openaire   +2 more sources

Chemokines CXCL10 and CCL2: differential involvement in intrathecal inflammation in multiple sclerosis

European Journal of Neurology, 2001
Studies of chemokines in cerebrospinal fluid (CSF) of patients with active multiple sclerosis (MS) have indicated that specific chemokines may have important roles in disease pathogenesis. We previously reported that CSF concentrations of CXCL10 (previously known as IP‐10) were elevated in MS patients in relapse, whilst levels of CCL2 (MCP‐1) were ...
Sørensen, Torben Lykke, Sellebjerg, F, Jensen, C V, Strieter, R M, Ransohoff, R M   +4 more
openaire   +2 more sources

Identification of CCR2‐binding features in Cytl1 by a CCL2‐like chemokine model

Proteins: Structure, Function, and Bioinformatics, 2011
AbstractChemokines are small secreted proteins that play an important role in immune responses and have also been shown to be involved in cartilage development and contributing to pathogenesis of a variety of diseases. They present a conserved 3D structure, so‐called IL8‐like chemokine fold, which is supported by conserved cysteines forming intra ...
Aurelie, Tomczak, M Teresa, Pisabarro
openaire   +2 more sources

Th1 (CXCL10) and Th2 (CCL2) chemokine expression in patients with immune thrombocytopenia

Human Immunology, 2010
Immune thrombocytopenia (ITP) is an acquired organ-specific autoimmune disease with a polarization of T(h)1. Both the T(h)1 chemokine CXCL10 and T(h)2 chemokine CCL2 have been studied in several autoimmune diseases, but the status of these chemokines in ITP is still unknown. The aims of this study were to determine the expression of CXCL10 and CCL2 and
Dongsheng, Gu, Zhenping, Chen, Haifeng, Zhao, Weiting, Du, Feng, Xue, Jing, Ge, Tao, Sui, Hao, Wu, Bin, Liu, Shihong, Lu, Lei, Zhang, Renchi, Yang   +11 more
openaire   +2 more sources

[CCL2 chemokine and transmission of nociceptive information].

Biologie aujourd'hui, 2011
Chemokines are small proteins belonging to the family of inflammatory cytokines whose main property is to attract and activate immune cells. Chemokines produce their biological activity by interacting with receptors belonging to the family of G protein-coupled receptors (GPCR).
openaire   +1 more source

The molecular structure and role of CCL2 (MCP‐1) and C‐C chemokine receptor CCR2 in skeletal biology and diseases

Journal of Cellular Physiology, 2021
Kevin Pfleger, Mei Liu
exaly  

[Correlations between chemokines CXCL12, CCL2, RANTES and early abortion].

Zhonghua yi xue za zhi, 2012
To explore the correlations between chemokines stromal cell-derived factor-1 (CXCL12), monocyte chemotactic protein-1 (CCL2), regulated upon activation normal T cell expressed and secreted (RANTES) and early abortion.The villus and decidua tissues of recurrent spontaneous abortion group (n = 26), medical abortion group (n = 30) and normal early ...
Yu, Zhang, Yan, Gu, Jun-xia, Li, Yi, Li
openaire   +1 more source

Does C-C Motif Chemokine Ligand 2 (CCL2) Link Obesity to a Pro-Inflammatory State?

International Journal of Molecular Sciences, 2021
Sebastian Dommel, Matthias Bluher
exaly