Results 271 to 280 of about 86,546 (282)

Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases

Archives of Pharmacal Research, 2013
Chemokines are members of the chemoattractant cytokine family. They play key roles in the trafficking of leukocytes and in the induction of chemotaxis through the activation of G protein-coupled receptor. Considerable interest has been paid to these molecules to elucidate their roles in the unique inflammatory responses elicited in the central nervous ...
Shambhunath, Bose, Jungsook, Cho
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Chemokines CXCL10 and CCL2: differential involvement in intrathecal inflammation in multiple sclerosis

European Journal of Neurology, 2001
Studies of chemokines in cerebrospinal fluid (CSF) of patients with active multiple sclerosis (MS) have indicated that specific chemokines may have important roles in disease pathogenesis. We previously reported that CSF concentrations of CXCL10 (previously known as IP‐10) were elevated in MS patients in relapse, whilst levels of CCL2 (MCP‐1) were ...
Sørensen, Torben Lykke, Sellebjerg, F, Jensen, C V, Strieter, R M, Ransohoff, R M   +4 more
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[CCL2 chemokine and transmission of nociceptive information].

Biologie aujourd'hui, 2011
Chemokines are small proteins belonging to the family of inflammatory cytokines whose main property is to attract and activate immune cells. Chemokines produce their biological activity by interacting with receptors belonging to the family of G protein-coupled receptors (GPCR).
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CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2005
The CC chemokine ligand-2 (CCL2) and its receptor CCR2 are essential for monocyte trafficking under inflammatory conditions. However, the mechanisms that determine the intensity and duration of alveolar monocyte accumulation in response to CCL2 gradients in inflamed lungs have not been resolved.
Ulrich A, Maus, Sandra, Wellmann, Christine, Hampl, William A, Kuziel, Mrigank, Srivastava, Matthias, Mack, M Brett, Everhart, Timothy S, Blackwell, John W, Christman, Detlef, Schlöndorff, Rainer M, Bohle, Werner, Seeger, Jürgen, Lohmeyer   +12 more
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Th1 (CXCL10) and Th2 (CCL2) chemokine expression in patients with immune thrombocytopenia

Human Immunology, 2010
Immune thrombocytopenia (ITP) is an acquired organ-specific autoimmune disease with a polarization of T(h)1. Both the T(h)1 chemokine CXCL10 and T(h)2 chemokine CCL2 have been studied in several autoimmune diseases, but the status of these chemokines in ITP is still unknown. The aims of this study were to determine the expression of CXCL10 and CCL2 and
Dongsheng, Gu, Zhenping, Chen, Haifeng, Zhao, Weiting, Du, Feng, Xue, Jing, Ge, Tao, Sui, Hao, Wu, Bin, Liu, Shihong, Lu, Lei, Zhang, Renchi, Yang   +11 more
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[Correlations between chemokines CXCL12, CCL2, RANTES and early abortion].

Zhonghua yi xue za zhi, 2012
To explore the correlations between chemokines stromal cell-derived factor-1 (CXCL12), monocyte chemotactic protein-1 (CCL2), regulated upon activation normal T cell expressed and secreted (RANTES) and early abortion.The villus and decidua tissues of recurrent spontaneous abortion group (n = 26), medical abortion group (n = 30) and normal early ...
Yu, Zhang, Yan, Gu, Jun-xia, Li, Yi, Li
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Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses

Neuroscience, 2007
Recent findings demonstrate that chemokines, and more specifically CC chemokine ligand 2 (CCL2 or monocyte chemoattractant protein-1), play a major role in pain processing. In the present study, we assess nociceptive responses of mice that overexpressed CCL2 under control of glial fibrillary acidic protein promoter (CCL2 tg).
J, Menetski, S, Mistry, M, Lu, J S, Mudgett, R M, Ransohoff, J A, Demartino, D E, Macintyre, C, Abbadie   +7 more
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CHEMOKINES, CC | MCP-1 (CCL2)–MCP-5 (CCL12)

2006
A.D. Luster, W.K. Hart, A.M. Tager
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CCL2 Chemokine in Central Tolerance

Scandinavian Journal of Immunology, 2014
Cedile, O., Lobner, M., Toft-Hansen, H., Frank, I., Wlodarczyk, A., Irla, M., Owens, T.   +6 more
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Melanoma susceptibility and progression: Association study between polymorphisms of the chemokine (CCL2) and chemokine receptors (CX3CR1, CCR5)

Journal of Dermatological Science, 2007
Mathieu, Rodero, Pauline, Rodero, Vincent, Descamps, Céleste, Lebbe, Pierre, Wolkenstein, Philippe, Aegerter, Dominique, Vitoux, Nicole, Basset-Seguin, Nicolas, Dupin, Bernard, Grandchamp, Nadem, Soufir, Christophe, Combadière, Philippe, Saiag   +12 more
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