Results 51 to 60 of about 3,367 (129)

Soluble inflammatory markers as predictors of virological response in patients with chronic hepatitis C virus infection treated with interferon-α plus ribavirin

Memorias do Instituto Oswaldo Cruz, 2011
The host immune response plays an important role in viral clearance in patients who are chronically infected with hepatitis C virus (HCV) and are treated with interferon and ribavirin.
Alexandre Sampaio Moura, Ricardo Andrade Carmo, Antonio Lucio Teixeira, Mauro Martins Teixeira, Manoel Otávio da Costa Rocha   +4 more
doaj   +1 more source

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

Advanced Science, Volume 13, Issue 19, 2 April 2026.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu, Xiaodong Chen, Chang Xu, Xuehua Qian, Binglong Bai, Ji Lin, Wenhai Deng, Xiang Wang, Yuekai Cui, Shengsheng Zhao, Zuoliang Xie, Tao You, Yingpeng Huang, Xian Shen, Xufeng Lu, Weijian Sun   +15 more
wiley   +1 more source

Putative transcriptomic biomarkers in the inflammatory cytokine pathway differentiate major depressive disorder patients from control subjects and bipolar disorder patients.

PLoS ONE, 2014
Mood disorders consist of two etiologically related, but distinctly treated illnesses, major depressive disorder (MDD) and bipolar disorder (BPD). These disorders share similarities in their clinical presentation, and thus show high rates of misdiagnosis.
Timothy R Powell, Peter McGuffin, Ursula M D'Souza, Sarah Cohen-Woods, Georgina M Hosang, Charlotte Martin, Keith Matthews, Richard K Day, Anne E Farmer, Katherine E Tansey, Leonard C Schalkwyk   +10 more
doaj   +1 more source

Analysis of blood plasma cytokine profile in healthy residents of the Republic of Guinea

Медицинская иммунология, 2020
The cytokine system is a large group of humoral factors  produced by immune cells and involved in the  pathogenesis of most  human diseases.  To assess the  significance of changes  in cytokines/chemokines under  pathological conditions, appropriate ...
N. A. Arsentieva, N. E. Lyubimova, O. K. Batsunov, A. V. Semenov, A. A. Totolian   +4 more
doaj   +1 more source

Beyond miRNA Cargo Profiles: Anti‐Inflammatory Roles of Extracellular Vesicle‐Enriched miRNAs Derived From Human Intervertebral Disc Cells Unveiled by Functional Testing

Journal of Extracellular Biology, Volume 5, Issue 4, April 2026.
ABSTRACT Intervertebral disc (IVD) degeneration is a leading cause of chronic low back pain and a major contributor to global disability. Understanding the molecular mechanisms underlying this condition is essential for developing targeted therapies. Among these mechanisms, microRNAs (miRNAs) have emerged as critical post‐transcriptional regulators of ...
Li Li, Aiwei Sun, Saber Ghazizadeh, Hadil Al‐Jallad, Kirby Upshaw, Saleh Alfaisali, Jean Ouellet, Peter Jarzem, Hosni Cherif, Lisbet Haglund   +9 more
wiley   +1 more source

Immunomodulatory effects of β-defensin 2 on macrophages induced immuno-upregulation and their antitumor function in breast cancer

BMC Immunology, 2022
Background Macrophages are mononuclear CD34+ antigen-presenting cells of defense mechanism and play dual roles in tumor burden. The immunomodulatory and their antitumor function of β-defensin 2 is still unclear, despite the accumulating evidence of the ...
Sonam Agarwal, Anita Chauhan, Khushwant Singh, Kunal Kumar, Rupinder Kaur, Marilyn Masih, Pramod Kumar Gautam   +6 more
doaj   +1 more source

AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes

Clinical &Experimental Allergy, Volume 56, Issue 4, Page 344-368, April 2026.
ABSTRACT The AllergoOncology field brings together the study of allergic and cancer immune responses, having evolved from early epidemiological studies that reported inverse associations between allergies, IgE and cancer risk. Insights from studying allergic inflammation are revealing previously unappreciated immune mechanisms that confer protective ...
Jakub Zydron, Anishaa Balaji, Jitesh Chauhan, Jack Alder, Xinyi Chen, Anna M. F. Wiegman, Aurelie Poli, Joanna Jacków‐Malinowska, Jack Cheeseman, Daniel I. R. Spencer, James McDonnell, James Spicer, Alexandra J. McCraw, Sophia N. Karagiannis   +13 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, Volume 20, Issue 3, Page 753-778, March 2026.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Spironolactone and Fibrosis in Heart Failure Risk: Machine Learning Analysis of HOMAGE Trial Plasma Proteomics

MedComm, Volume 7, Issue 3, March 2026.
In HOMAGE, 276 plasma proteins were profiled using Olink panels. Machine learning algorithms identified galectin‐9 (GAL9), thrombospondin‐2 (THBS2), and NT‐proBNP as predictors of changes in procollagen type I C‐terminal propeptide (PICP) after spironolactone treatment.
Susana Ravassa, Nicolas Girerd, Frank Edelman, Begoña López, João Pedro Ferreira, Daniela Zurkan, Gorka San José, Iñigo Latasa, Pierpaolo Pellicori, Franco Cosmi, Johannes Petutschnigg, Stephane Heymans, Hans‐Peter Brunner‐La Rocca, Burkert Pieske, Christian Delles, Andrew L. Clark, Javier Díez, Faiez Zannad, John G. F. Cleland, Arantxa González, the HOMAGE Trial Committees and Investigators   +20 more
wiley   +1 more source

Molecular Patterns of Subclinical and Clinical Rejection of Kidney Allograft: Quantity Matters

Kidney & Blood Pressure Research, 2015
Background/Aims: Subclinical rejection diagnosed from protocol biopsies is thought to be a risk factor of long- term allograft dysfunction. The reason why in some patients subclinical rejection does not represent risk for progression is not fully ...
Mariana Wohlfahrtova, Irena Tycova, Eva Honsova, Alena Lodererova, Ondrej Viklicky   +4 more
doaj   +1 more source