CCL24 and Fibrosis: A Narrative Review of Existing Evidence and Mechanisms [PDF]
CellsTissue fibrosis results from a dysregulated and chronic wound healing response accompanied by chronic inflammation and angiogenesis. Regardless of the affected organ, fibrosis shares the following common hallmarks: the recruitment of immune cells ...
Raanan Greenman, Chris J Weston
exaly +6 more sources
CCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis
JCI Insight, 2023 ˆCCL24 is a pro-fibrotic, pro-inflammatory chemokine expressed in several chronic fibrotic diseases. In the liver, CCL24 plays a role in fibrosis and inflammation, and blocking CCL24 led to reduced liver injury in experimental models. We studied the role
Ilan Vaknin +2 more
exaly +5 more sources
A blocking monoclonal antibody to CCL24 alleviates liver fibrosis and inflammation in experimental models of liver damage [PDF]
JHEP Reports, 2020 Background & Aims: C-C motif chemokine ligand 24 (CCL24) is a chemokine that regulates inflammatory and fibrotic activities through its receptor, C-C motif chemokine receptor (CCR3).
Yaakov Maor +2 more
exaly +6 more sources
CellsPrimary sclerosing cholangitis (PSC) is an inflammatory and fibrotic biliary disease lacking approved treatment. We studied CCL24, a chemokine shown to be overexpressed in damaged bile ducts, and its involvement in key disease-related mechanisms.
Raanan Greenman +2 more
exaly +5 more sources
Peritoneal MSCs-derived exosomes suppress CCL24 synthesis through miR-320d delivery contributing to the improvement of peritoneal dialysis-associated fibrosis [PDF]
Scientific ReportsMesothelial-to-mesenchymal transition (MMT) is a key pathological process driving peritoneal fibrosis in patients undergoing peritoneal dialysis (PD).
Xinhui Zhao +6 more
doaj +2 more sources
Inflammatory Mediators of Alzheimer’s Disease Characterized in a Mouse Model (APP/PS1) [PDF]
NeuroSciAlzheimer’s disease (AD) is marked by amyloid plaques, hyperphosphorylated TAU proteins, and neuroinflammation. The APP/PS1 mouse model is widely used to study AD pathogenesis.
Adrian Jorda +9 more
doaj +2 more sources
Bioengineered Tumor‐Derived Extracellular Vehicles Suppressed Colorectal Cancer Liver Metastasis and Bevacizumab Resistance [PDF]
Advanced ScienceAntiangiogenic therapies, such as bevacizumab, are among the causes of cancer‐related death in patients with colorectal cancer (CRC) with liver metastasis.
Junjiang Wang +7 more
doaj +2 more sources
Millettia speciosa reprograms the lung proteome and suppresses CCL24-driven eosinophilic inflammation in allergic asthma [PDF]
Frontiers in AllergyBackgroundAsthma is a Th2-skewed inflammatory disorder characterized by eosinophilic infiltration, cytokine dysregulation, and airway remodeling.
Hangrui Yang +7 more
doaj +2 more sources
Pollutant particles enhance house dust mite induced type 2 inflammation and the recruitment of monocyte derived Cd11c+ Gpnmb+ macrophages to the airway lumen [PDF]
Particle and Fibre ToxicologyBackground Air pollution particles exacerbate allergic asthma and can enhance inflammatory responses to allergen exposure, but the cellular mechanisms involved remain incompletely defined. We examined how diesel exhaust particles (DEP) enhance house-dust-
Kirsty Meldrum +2 more
doaj +2 more sources
Plasma inflammatory biomarker profiles across the Alzheimer's disease spectrum in the Bio-Hermes cohort. [PDF]
Alzheimers DementAbstract INTRODUCTION Inflammation contributes to Alzheimer's disease (AD), but its stage‐specific and amyloid‐dependent patterns remain unclear. METHODS We analyzed 964 participants from the Bio‐Hermes cohort (cognitively normal [CN] = 404, mild cognitive impairment [MCI] = 302, mild AD = 258). Plasma levels of 32 cytokines, neurofilament light chain (
Hussain Z +5 more
europepmc +2 more sources