Results 11 to 20 of about 4,498 (153)

The Role of CCL24 in Systemic Sclerosis

Rambam Maimonides Medical Journal, 2023
Systemic sclerosis (SSc) is a chronic immune-mediated disease characterized by microangiopathy, immune dysregulation, and progressive fibrosis of the skin and internal organs.
Hilit Levy, Udi Gluschnaider, Alexandra Balbir-Gurman   +2 more
doaj   +3 more sources

Eosinophils in Colorectal Neoplasms Associated with Expression of CCL11 and CCL24 [PDF]

Journal of Pathology and Translational Medicine, 2016
Background: A decrease in the number of tissue eosinophils is known to reflect the malignancy potential of neoplastic lesions and even prognosis. Increased levels of the chemokines CCL11 and CCL24 in serum and tissue are also known to have diagnostic ...
Hyuck Cho, Sung-Jig Lim, Kyu Yeoun Won, Go Eun Bae, Gou Young Kim, Ji Won Min, Byeong-joo Noh   +6 more
doaj   +3 more sources

Involvement of Eotaxins (CCL11, CCL24, CCL26) in Pathogenesis of Osteopenia and Osteoporosis

Iranian Journal of Public Health, 2020
Background: The purpose of this study was to investigate the role of eotaxin family members including C-C motif chemokine 11 (CCL11), C-C motif chemokine 24 (CCL24), and C-C motif chemokine 26 (CCL26) as the subgroups of CC-chemokine in patients affected
Hadis AHMADI, Hossein KHORRAMDELAZAD, Gholamhossein HASSANSHAHI, Mitra ABBASI FARD, Zahra AHMADI, Mojgan NOROOZI KARIMABAD, Majid MOLLAHOSSEINI   +6 more
doaj   +4 more sources

TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus.

PLoS Pathogens, 2017
TPL-2 (COT, MAP3K8) kinase activates the MEK1/2-ERK1/2 MAPK signaling pathway in innate immune responses following TLR, TNFR1 and IL-1R stimulation. TPL-2 contributes to type-1/Th17-mediated autoimmunity and control of intracellular pathogens.
Yashaswini Kannan, Lewis J Entwistle, Victoria S Pelly, Jimena Perez-Lloret, Alan W Walker, Steven C Ley, Mark S Wilson   +6 more
doaj   +4 more sources

Methionine enkephalin upregulates the immune function of RAW264.7 cells to inhibit the infection of Nelson Bay orthoreoviruses [PDF]

Scientific Reports
Preliminary research has found that MENK can upregulate the antiviral state of macrophages to inhibit influenza virus infection. To further study the immunomodulatory mechanism of MENK in macrophages against reovirus, we used RNA-Seq technology to ...
Xiaoli Tao, Xiaomeng Wang, Zhuping Ma, Miaojuan Chen, Jing Tian   +4 more
doaj   +2 more sources

CXCL12 and CXCL13 as potential biomarkers for disease severity and recurrence in respiratory syncytial virus bronchiolitis [PDF]

Scientific Reports
To examine chemokine expression in children with Respiratory Syncytial Virus (RSV) bronchiolitis and evaluate its clinical utility for early warning and prognosis. Five hospitalised RSV bronchiolitis children and five matched controls were studied.
Lin Zhang, Yuanyu Lv, Zhiao Du, Jiawei Chen, Peng Mo, Xuena Xu, Huiming Sun, Yongdong Yan, Canhong Zhu, Li Huang, Chuangli Hao, Xiuxia Zhou, Heting Dong, Zhengrong Chen   +13 more
doaj   +2 more sources

Eosinophil recruitment and activation in the central nervous system of patients with subarachnoid neurocysticercosis [PDF]

Journal of Neuroinflammation
Background and objectives Subarachnoid neurocysticercosis (SANCC) is the most severe manifestation of neurocysticercosis. Most complications (communicating hydrocephalus, ischemic stroke, aneurysm, and subarachnoid hemorrhage) are due to inflammation ...
Emily Miltenberger, Janitzio Guzmán, Rodaba Rahim, Miranda Yu, Michelle Makiya, Perla Adames Castillo, Soo Ching Lee, Theodore E. Nash, Amy D. Klion, Thomas B. Nutman, Elise M. O’Connell   +10 more
doaj   +2 more sources

MicroRNA expression in peripheral blood of children with asthma and the role of miR-31-5p in childhood asthma progression [PDF]

Scientific Reports
MicroRNAs (miRNAs) have emerged as critical epigenetic regulators in the pathogenesis of childhood bronchial asthma. This study employed high-throughput sequencing to explore miRNA expression profiles in an asthma cohort, with a focus on elucidating the ...
Wenwei Luo, Gang Li, Luting Zhou, Ting Wang, Jiawei Chen, Heting Dong, Li Huang, Canhong Zhu, Yongdong Yan, Liwen Zhang, Yu Wan, Zhengrong Chen   +11 more
doaj   +2 more sources

The role of MXRA7 in bone marrow senescence involves macrophage polarization and microenvironment remodeling [PDF]

Blood Science
Marrow senescence contributes to overall organismal aging and involves functional alterations in both the mesenchymal and hematopoietic compartments of bone marrow.
Yuzhen Qin, Ziyan Zhao, Yihan Chen, Yudan Zheng, Kunpeng Ma, Dandan Lin, Xin Liu, Yiqiang Wang   +7 more
doaj   +2 more sources

Mechanical stiffness promotes skin fibrosis via Piezo1-Wnt2/Wnt11-CCL24 positive feedback loop

Cell Death and Disease
Skin fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) caused by fibrotic disorders of the skin. In recent years, ECM stiffness has emerged as a prominent mechanical cue that precedes skin fibrosis and drives its ...
Jiahao He, Xinwei Cheng, Bin Fang, Shengzhou Shan, Qingfeng Li   +4 more
doaj   +3 more sources