Results 41 to 50 of about 3,367 (129)

High SIGLEC10‐Expressing Tumor‐Associated Macrophages Participate in Remodeling the Tumor Immune Microenvironment and Predict Poor Prognosis in Colorectal Cancer

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT Background Sialic acid‐binding immunoglobulin‐like lectin 10 (SIGLEC10), a member of the SIGLEC family, is selectively expressed on multiple immune cell subsets and plays a key role in immune regulation through the recognition of sialylated ligands.
Chuang Miao, Fei Qian
wiley   +1 more source

Transcriptional Profiling of Mouse Eosinophils Identifies Distinct Gene Signatures Following Cellular Activation

Frontiers in Immunology, 2021
Eosinophils are multifunctional, evolutionary conserved leukocytes that are involved in a plethora of responses ranging from regulation of tissue homeostasis to host defense and cancer.
Avishay Dolitzky, Guy Shapira, Sharon Grisaru-Tal, Inbal Hazut, Shmulik Avlas, Yaara Gordon, Micahl Itan, Noam Shomron, Ariel Munitz   +8 more
doaj   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Role of the sympathetic nervous system in carbon tetrachloride-induced hepatotoxicity and systemic inflammation. [PDF]

PLoS ONE, 2015
Carbon tetrachloride (CCl4) is widely used as an animal model of hepatotoxicity and the mechanisms have been arduously studied, however, the contribution of the sympathetic nervous system (SNS) in CCl4-induced acute hepatotoxicity remains controversial ...
Jung-Chun Lin, Yi-Jen Peng, Shih-Yu Wang, Ton-Ho Young, Donald M Salter, Herng-Sheng Lee   +5 more
doaj   +1 more source

Development and functional adaptation of intestinal macrophages across the lifespan

Clinical &Translational Immunology, Volume 15, Issue 6, 2026.
This article discusses intestinal macrophage development, including the influence of developmental origins and life stages; ontogeny and functional heterogeneity; preclinical and clinical evidence. Abstract Macrophages of the gastrointestinal system are central regulators of gut development, homeostasis and disease, yet their origin, functional ...
Baha Mustafa, Elisa L Hill‐Yardin, Sarah J Spencer   +2 more
wiley   +1 more source

Possible Mechanisms of Eosinophil Accumulation in Eosinophilic Pneumonia

Biomolecules, 2020
Eosinophilic pneumonia (EP), including acute EP and chronic EP, is characterized by the massive pulmonary infiltration of eosinophils into the lung. However, the mechanisms underlying the selective accumulation of eosinophils in EP have not yet been ...
Kazuyuki Nakagome, Makoto Nagata
doaj   +1 more source

Differential expression of chemokine and matrix re-modelling genes is associated with contrasting schistosome-induced hepatopathology in murine models. [PDF]

PLoS Neglected Tropical Diseases, 2011
The pathological outcomes of schistosomiasis are largely dependent on the molecular and cellular mechanisms of the host immune response. In this study, we investigated the contribution of variations in host gene expression to the contrasting hepatic ...
Carly R Perry, Melissa L Burke, Deborah J Stenzel, Donald P McManus, Grant A Ramm, Geoffrey N Gobert   +5 more
doaj   +1 more source

A two-sample Mendelian randomization analysis: causal association between chemokines and pan-carcinoma

Frontiers in Genetics, 2023
Objective: According to the 2020 data from the World Health Organization (WHO), cancers stand as one of the foremost contributors to global mortality. Revealing novel cancer risk factors and protective factors is of paramount importance in the prevention
Kai Cui, Kai Cui, Na Song, Na Song, Yanwu Fan, Liqun Zeng, Pingyu Shi, Ziwei Wang, Wei Su, Haijun Wang, Haijun Wang   +10 more
doaj   +1 more source

COX2+/PDGFRα+ fibroblasts selectively localize near bile ducts and interact with immune cells in early liver fibrosis in mice

Physiological Reports, Volume 14, Issue 10, May 2026.
COX2+PDGFRα+ fibroblasts show selective localization and immune crosstalk in bile duct ligation‐induced liver fibrosis. Abstract Liver fibrosis is a growing global health problem with no effective treatments. PDGFRα‐positive fibroblasts are the main drivers of liver fibrosis, but their cellular heterogeneity is not fully understood.
Momo Goto, Tamaki Kurosawa, Hiroyuki Koike, Noriyuki Kaji, Ichiro Manabe, Taiki Mihara, Takashi Chaen, Yumiko Oishi, Masatoshi Hori   +8 more
wiley   +1 more source

Inhaled Angiopoietin‐Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Inhaled antisense oligonucleotides targeting ANGPTL4 attenuate inflammation, preserve barrier integrity, and reduce fibrosis in both infectious and sterile lung injury models. Integrated transcriptomic analysis reveals a conserved ANGPTL4‐regulated gene network coordinating hypoxic, inflammatory, apoptotic, and stress‐response pathways.
Haiyang Fan, Yuanyang Tan, Junhang Zhang, Xiaoya Liu, Jing Qu, Damien Chua, Hong Sheng Cheng, Joseph Han Sol Kim, Yu Xuan Liu, Changfei Qin, Yingzi Liu, Dezhi Li, Jikang Qiu, Mengshi Chi, Mingmin Bi, Qiwei Zhang, Yun Li, Masoumeh Motamedi Joibari, Stefan K Nilsson, Nguan Soon Tan, Yunping Fan, Liang Li   +21 more
wiley   +1 more source