Results 61 to 70 of about 3,367 (129)

Targeted blood proteome profiling using NULISAseq identifies a high‐performance biomarker panel for Aβ pathology quantification and staging

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION While current blood‐based biomarkers for Alzheimer's disease (AD) are effective for determining amyloid beta (Aβ) pathology positivity/negativity, they are insufficient for quantifying Aβ plaque deposition. METHODS We profiled 325 plasma proteins in a Hong Kong Chinese cohort using the Nucleic Acid Linked Immuno‑Sandwich Assay ...
Wenyue Zheng, Yuanbing Jiang, Hiu Yi Wong, Wan Wa Wong, Lily K. W. Cheng, Elaine Y. L. Cheng, Bonnie W. Y. Wong, Ronnie M. N. Lo, Siu Ki Leung, Fanny C. Ip, Jacqueline K. Y. Yuen, Yat Fung Shea, Wai Ming Wong, Chun Keung Shum, Hok Man Wai, Vincent C. T. Mok, Timothy C. Y. Kwok, Kin Y. Mok, Amanda Heslegrave, John Hardy, Henrik Zetterberg, Amy K. Y. Fu, Nancy Y. Ip   +22 more
wiley   +1 more source

Serum cytokine profiles and metabolic tumor burden in patients with non-small cell lung cancer undergoing palliative thoracic radiation therapy

Advances in Radiation Oncology, 2018
Purpose: Radiation therapy effectively kills cancer cells and elicits local effects in the irradiated tissue. The aim of this study was to investigate the kinetics of cytokines in the serum of patients with lung cancer undergoing radiation therapy and to
Hanne A. Eide, MD, Ingerid Skjei Knudtsen, MSc, Vandana Sandhu, PhD, Ayca M. Løndalen, MD, Ann Rita Halvorsen, MSc, Azadeh Abravan, MSc, Elin H. Kure, PhD, Trond V. Bogsrud, MD, PhD, Odd Terje Brustugun, MD, PhD, Jon Amund Kyte, MD, PhD, Eirik Malinen, PhD, Åslaug Helland, MD, PhD   +11 more
doaj   +1 more source

The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu, Lingli Shi, Aifang Lu, Lijuan Cui, Haiqing Qian, Jiahui Wang, Mengyu Tang, Lili Zhu, Lihong Wang   +8 more
wiley   +1 more source

Role of CXCR3 and CXCR6 on Circulating T Cells in Patients With Parkinson's Disease

Scandinavian Journal of Immunology, Volume 103, Issue 2, February 2026.
CXCR3 and CXCR6 expression may be dependent on CD8+ T lymphocytes to participate in the pathogenesis of PD, while has no effects on peripheral inflammation. ABSTRACT Immune dysregulation is involved in Parkinson's disease (PD), but the roles of C‐X‐C motif chemokine receptor 3 (CXCR3)/chemokine receptor 6 (CXCR6) on T cells and their correlation with ...
Yufeng Zhang, Zhuangzhuang Ren, Shuangshuang Jia, Jinming Han, Xiaoling Zhong, Bo Fu, Haoran Wang, Shiping Xu, Tingting Li, Feng Qiu   +9 more
wiley   +1 more source

Mechanical stiffness promotes skin fibrosis via Piezo1-Wnt2/Wnt11-CCL24 positive feedback loop

Cell Death and Disease
Skin fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) caused by fibrotic disorders of the skin. In recent years, ECM stiffness has emerged as a prominent mechanical cue that precedes skin fibrosis and drives its ...
Jiahao He, Xinwei Cheng, Bin Fang, Shengzhou Shan, Qingfeng Li   +4 more
doaj   +1 more source

Doxycycline and Benznidazole Reduce the Profile of Th1, Th2, and Th17 Chemokines and Chemokine Receptors in Cardiac Tissue from Chronic Trypanosoma cruzi-Infected Dogs

Mediators of Inflammation, 2016
Chemokines (CKs) and chemokine receptors (CKR) promote leukocyte recruitment into cardiac tissue infected by the Trypanosoma cruzi. This study investigated the long-term treatment with subantimicrobial doses of doxycycline (Dox) in association, or not ...
Guilherme de Paula Costa, Laís Roquete Lopes, Maria Cláudia da Silva, Aline Luciano Horta, Washington Martins Pontes, Cristiane M. Milanezi, Paulo Marcos da Mata Guedes, Wanderson Geraldo de Lima, Richard Schulz, João Santana da Silva, Andre Talvani   +10 more
doaj   +1 more source

The CCL11‐CCR3 Axis Regulates the Aggravation of Neuroinflammation in Astrocytic Necroptosis After Cerebral Ischemia

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Schematic diagram of the triggering mechanism of necroptosis after cerebral ischemia. First, CCL11 targetedly binds to CCR3 on the surface of astrocytes and upregulates the expression of CCR3. After CCR3 activation, it triggers the transcriptional activation of necroptosis.
Han Yin, Xinmin Zhang, Meng Li, Yunzhe Liu, Yingying Zhang, Yao Zhang, Hui Ci, Kun Li, ShanShan Yang, Guangyou Wang, Tongshuai Zhang   +10 more
wiley   +1 more source

mRNA EXPRESSION OF SOME CHEMOKINES AND THEIR RECEPTORS IN NASAL MUCOSA OF HEALTHY PERSONS

Медицинская иммунология, 2014
.  Chemokines  are  a  key  factor  that ensures  the  participation  of  different  cell  types  in the  immunological  protection  of  mucosa.  In  our study  we  chose  some  chemokines  that  ensured  the chemotaxis of neutrophils (CXCL8/IL-8 ...
A. A. Bibkova, K. A. Sysoyev, A. V. Semenov, N. E. Lyubimova, N. A. Arsentieva, V. I. Trofimov, Areg A. Totolian   +6 more
doaj   +1 more source

Acute and chronic impact of interleukin-33 stimulation on chemokines and growth factors in human cord blood-derived mast cells.

PLoS ONE
BackgroundMast cells (MCs) are multifaceted immune cells that are capable of recognizing and responding to various stimuli by releasing an array of cytokines.
Sherin Bakhashab, Ghalya H Banafea, Farid Ahmed, Reem Alsolami, Hans-Juergen Schulten, Kalamegam Gauthaman, Muhammad Imran Naseer, Peter Natesan Pushparaj   +7 more
doaj   +1 more source

Adipocyte-derived CXCL10 in obesity promotes the migration and invasion of ovarian cancer cells

Journal of Ovarian Research
Background As a widespread epidemic, obesity poses a significant risk to health and leads to physiological abnormalities, including diabetes mellitus and inflammation.
Zhe Wang, Qingjian Ou, Ying Liu, Yuanyuan Liu, Qingwei Zhu, Jingqiu Feng, Fengze Han, Lu Gao   +7 more
doaj   +1 more source