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Fibroblasts as Immunological Sentinels in Cutaneous Inflammation: A Review. [PDF]

J Clin Med
Quan T.
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Gene Variations of Chemokine and Chemokine Receptor CXCL12/CXCR4 in Lung Cancer

Journal of Environmental Pathology, Toxicology and Oncology, 2023
Lung cancer is the most common type of cancer in the world and about 1 million people die from lung cancer every year in the world. Inflammation is an important factor in the onset, progression and metastasis of lung cancer. The most important regulators of inflammation are chemokines and chemokine receptors.
Cansu, Ozbayer, Emine, Yagci, Guntulu, Ak, Selma, Metintas, Muzaffer, Metintas, Hulyam, Kurt   +5 more
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Allosteric modulation of the chemokine receptor-chemokine CXCR4-CXCL12 complex by tyrosine sulfation

International Journal of Biological Macromolecules, 2022
The chemokine receptor CXCR4 and its cognate ligand CXCL12 mediate pathways that lead to cell migration and chemotaxis. Although the structural details of related receptor-ligand complexes have been resolved, the roles of the N-terminal domain of the receptor and post-translational sulfation that are determinants of ligand selectivity and affinity ...
Archana, Sonawani, Shalmali, Kharche, Debjani, Dasgupta, Durba, Sengupta   +3 more
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Pathological roles of the homeostatic chemokine CXCL12

Cytokine & Growth Factor Reviews, 2018
CXCL12 is a CXC chemokine that traditionally has been classified as a homeostatic chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis and angiogenesis. In contrast to these homeostatic functions, increased expression of CXCL12 in general, or of a specific CXCL12 splicing variant has been demonstrated in various ...
Rik, Janssens, Sofie, Struyf, Paul, Proost   +2 more
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The role of the chemokine CXCL12 in osteoclastogenesis

Trends in Endocrinology & Metabolism, 2007
The chemokine CXCL12 (variously termed stromal-derived factor 1 or B cell-stimulating factor) is a highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. CXCL12 has crucial roles in the formation of multiple organ systems during embryogenesis and in the regulation of bone marrow haematopoiesis and immune function in the ...
Gronthos, S., Zannettino, A.
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Roles of Chemokine CXCL12 and its Receptors in Ischemic Stroke

Current Drug Targets, 2012
Chemokine CXC ligand 12 (CXCL12), originally named stromal cell-derived factor-1 (SDF-1), is a member of the CXC chemokine subfamily. CXCL12 is found to be expressed by all cell types that are presented in the central nervous system (CNS). It works in conjunction with the G-protein coupled receptor CXCR4, which is found at the surface of a variety of ...
Yongting, Wang, Jun, Huang, Yaning, Li, Guo-Yuan, Yang   +3 more
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The CXCL12–CXCR4 Chemokine Pathway: A Novel Axis Regulates Lymphangiogenesis

Clinical Cancer Research, 2012
Abstract Purpose: Lymphangiogenesis, the growth of lymphatic vessels, contributes to lymphatic metastasis. However, the precise mechanism underlying lymphangiogenesis remains poorly understood. This study aimed to examine chemokine/chemokine receptors that directly contribute to chemoattraction of activated lymphatic endothelial cells
Wei, Zhuo, Lin, Jia, Nan, Song, Xin-An, Lu, Yanping, Ding, Xiaofeng, Wang, Xiaomin, Song, Yan, Fu, Yongzhang, Luo   +8 more
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CXC chemokine ligand 12 (CXCL12) and its receptor CXCR4

Journal of Molecular Medicine, 2014
Chemokines were recognized originally for their ability to dictate the migration and activation of leukocytes. However, CXC chemokine ligand 12 (CXCL12, also known as stromal cell-derived factor-1) and its receptor CXCR4 are the first chemokine and receptor that have been shown to be critical for developmental processes, including homing and ...
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Modulation of rat oligodendrocyte precursor cells by the chemokine CXCL12

NeuroReport, 2006
Migration, proliferation, and differentiation of oligodendrocyte precursor cells are essential for the assembly of myelin in the central nervous system. Knowledge on the regulation of these precursor cells is therefore of great importance for the understanding of developmental myelination and remyelination in demyelinating diseases.
Maysami, Samaneh, Nguyen, Dan, Zobel, Franziska, Pitz, Caroline, Heine, Sandra, Höpfner, Michael, Stangel, Martin   +6 more
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