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Sustained Delivery of Chemokine CXCL12 from Chemically Modified Silk Hydrogels
Biomacromolecules, 2015A delivery platform was developed using silk-based hydrogels, and sustained delivery of the cationic chemokine CXCL12 at therapeutically relevant doses is demonstrated. Hydrogels were prepared from plain silk and silk that had been chemically modified with sulfonic acid groups. CXCL12 was mixed with the silk solution prior to gelation, resulting in 100%
Paige N, Atterberry +5 more
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Chemokine CXCL12 enhances proliferation in pre‐B‐ALL via STAT5 activation
Pediatric Blood & Cancer, 2007AbstractBackgroundCXCL12 (SDF‐1α) is a chemokine, which plays an important role in normal B‐cell lymphopoesis, migration and homing to the bone marrow (BM) and previous studies have suggested a role for CXCL12 and its receptor CXCR4 in the pathogenesis of ALL.PurposeCXCL12 levels in serum were evaluated from ALL‐children and controls.
Frida, Mowafi +5 more
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CXC chemokine ligand 12 (CXCL12) in atherosclerosis: An underlying therapeutic target
Clinica Chimica Acta, 2019CXC chemokine ligand 12 (CXCL12) is a specific chemokine ligand and plays a significant role in cell chemotaxis. Upon binding to CXC chemokine receptor 4 (CXCR4) or CXCR7, CXCL12 can activate different signaling cascades to regulate cell proliferation, migration, and metabolism.
Jia-Hui, Gao +2 more
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Glioblastomas: Role of CXCL12 Chemokine
2010Chemokines are small pro-inflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors on the plasma membrane of target cells. They are also the major regulators of cell trafficking. Chemokines and their receptors were initially associated with the trafficking of leukocytes during physiological immune
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The roles of chemokine CXCL12 in embryonic and brain tumor angiogenesis
Seminars in Cancer Biology, 2009The formation of blood vessels in embryos and tumors are different processes but under the control of common molecular mechanisms. Chemokine CXCL12 involved in both embryonic and tumor angiogenesis. In this review, we summarize recent advances in understanding the roles of CXCL12 in brain tumor angiogenesis/vasculogenesis.
Meizhang, Li, Richard M, Ransohoff
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Neuroprotective actions of the chemokine CXCL12
Chemokines are cellular mediators known for their role in immune/inflammatory responses - traditionally, yet simplistically, associated to neuronal damage. However, recent research has not only provided evidence about the beneficial nature of a controlled immune/inflammatory response in the central nervous system (CNS), but also suggested novel ...Jaclyn Nicolai +2 more
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[Correlations between chemokines CXCL12, CCL2, RANTES and early abortion].
Zhonghua yi xue za zhi, 2012To explore the correlations between chemokines stromal cell-derived factor-1 (CXCL12), monocyte chemotactic protein-1 (CCL2), regulated upon activation normal T cell expressed and secreted (RANTES) and early abortion.The villus and decidua tissues of recurrent spontaneous abortion group (n = 26), medical abortion group (n = 30) and normal early ...
Yu, Zhang, Yan, Gu, Jun-xia, Li, Yi, Li
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The role of chemokine CXCL12 in obesity induced PCa progression
2020Prostate cancer (PCa) is the second leading cause of cancer in men, in the United States. Several studies have shown that overweight or obesity increases PCa progression and PCa mortality. However, the mechanisms underlying this association are not clear.
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MM-124 CXCL12 Chemokine and Relationship With Multiple Myeloma
Clinical Lymphoma Myeloma and Leukemia, 2023Ekin Ece Gürer +4 more
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