Results 41 to 50 of about 240,302 (314)

C–C motif chemokine ligand 2/C–C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

Neural Regeneration Research
Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.
Xiangzi Wang, Xiaofei Niu, Yingkai Wang, Yang Liu, Cheng Yang, Xuyi Chen, Zhongquan Qi   +6 more
doaj   +1 more source

Chemokines, Chemokine Receptors and Atherosclerosis

, 2005
Publisher Summary This chapter focuses on chemokines, chemokine receptors, and atherosclerosis. Chemokines play essential roles in inflammation and disease. This family of inflammatory mediators has diverse roles in both immune and inflammatory responses, including the regulation of cellular recruitment, activation, and differentiation.
John, A, Channon, K, Greaves, D
openaire   +2 more sources

Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity.

PLoS Biology, 2020
Chemokines and their receptors are orchestrators of cell migration in humans. Because dysregulation of the receptor-chemokine system leads to inflammation and cancer, both chemokines and receptors are highly sought therapeutic targets.
Tony Ngo, Bryan S Stephens, Martin Gustavsson, Lauren G Holden, Ruben Abagyan, Tracy M Handel, Irina Kufareva   +6 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets

Journal of Immunology Research, 2014
Chemokines are small proteins that primarily regulate the traffic of leukocytes under homeostatic conditions and during specific immune responses. The chemokine-chemokine receptor system comprises almost 50 chemokines and approximately 20 chemokine ...
M. Isabel Palacios-Arreola, Karen E. Nava-Castro, Julieta I. Castro, Eduardo García-Zepeda, Julio C. Carrero, Jorge Morales-Montor   +5 more
doaj   +1 more source

Molecular insights into kinase mediated signaling pathways of chemokines and their cognate G protein coupled receptors

Frontiers in Bioscience-Landmark, 2020
Chemokines are small regulatory proteins that play a crucial role in the coordinated migration of cell populations to the site of infection/inflammation by binding to their cognate receptors.
Deepak Kumar Tripathi, Krishna Mohan Poluri   +1 more
doaj   +1 more source

Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8

Nature Communications, 2023
The C-C motif chemokine receptor 8 (CCR8) is a class A G-protein coupled receptor that has emerged as a promising therapeutic target in cancer. Targeting CCR8 with an antibody has appeared to be an attractive therapeutic approach, but the molecular basis
Dawei Sun, Yonglian Sun, Eric Janezic, Tricia Zhou, Matthew Johnson, Caleigh Azumaya, Sigrid Noreng, Cecilia Chiu, Akiko Seki, Teresita L. Arenzana, John M. Nicoludis, Yongchang Shi, Baomei Wang, Hoangdung Ho, Prajakta Joshi, Christine Tam, Jian Payandeh, Laëtitia Comps-Agrar, Jianyong Wang, Sascha Rutz, James T. Koerber, Matthieu Masureel   +21 more
doaj   +1 more source

Chemokines and Chemokine Receptors: Orchestrating Tumor Metastasization [PDF]

International Journal of Molecular Sciences, 2018
Metastasis still represents the primary cause of cancer morbidity and mortality worldwide. Chemokine signalling contributes to the overall process of cancer growth and metastasis, and their expression in both primary tumors and metastatic lesions correlate with prognosis.
MARCUZZI, ELISABETTA, Angioni, Roberta, Molon, Barbara, Calì, Bianca   +3 more
openaire   +3 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice

eLife, 2022
Inflammatory chemokines and their receptors are central to the development of inflammatory/immune pathologies. The apparent complexity of this system, coupled with lack of appropriate in vivo models, has limited our understanding of how chemokines ...
Laura Medina-Ruiz, Robin Bartolini, Gillian J Wilson, Douglas P Dyer, Francesca Vidler, Catherine E Hughes, Fabian Schuette, Samantha Love, Marieke Pingen, Alan James Hayes, Jun Fu, Adrian Francis Stewart, Gerard J Graham   +12 more
doaj   +1 more source