Results 111 to 120 of about 763,282 (296)

Chemokine receptor specific antibodies in cancer immunotherapy: achievements and challenges

Frontiers in Immunology, 2015
The 1990s brought a burst of information regarding the structure, expression pattern, and role in leukocyte migration and adhesion of chemokines and their receptors. At that time, the FDA approved the first therapeutic antibodies for cancer treatment.
Maria eVela, Mariana eAris, Mercedes eLlorente, Jose A. eGarcia-Sanz, Leonor eKremer   +4 more
doaj   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Chemokine receptors in GtoPdb v.2025.1 [PDF]

Chemokine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Chemokine Receptors [459, 458, 32]) comprise a large subfamily of 7TM proteins that bind one or more chemokines, a large family of small cytokines typically possessing ...
Nomiyama, Hisayuki, Yoshie, Osamu, Luster, Andrew D., Power, Christine A., Proudfoot , Amanda E. I., Oppenheim, Joost J., Rot, Antal, Ben-Baruch, Adit, Locati, Massimo, Matsushima, Kouji, Murphy, Philip M., Graham, Gerard J., Burkhardt, Amanda M., Hills, Rebecca, Rosenkilde, Mette M., Sparre-Ulrich, Alexander H., Combadiere, Christophe, Bachelerie, Francoise, Nibbs, Robert J. B., Uddin, Mohib, Monaghan, Amy E., Farber, Joshua M., Sozzani, Silvano, Mantovani, Alberto, Förster, Reinhold, Moschovakis, Georgios L., Charo, Israel F., Zlotnik, Albert, Thelen, Marcus, Horuk, Richard   +29 more
core   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Chemokine receptors in GtoPdb v.2025.3 [PDF]

Chemokine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Chemokine Receptors [460, 459, 32, 125]) comprise a large subfamily of 7TM proteins that bind one or more chemokines, a large family of small cytokines typically possessing ...
Nomiyama, Hisayuki, Yoshie, Osamu, Luster, Andrew D., Power, Christine A., Proudfoot , Amanda E. I., Oppenheim, Joost J., Rot, Antal, Ben-Baruch, Adit, Locati, Massimo, Matsushima, Kouji, Murphy, Philip M., Graham, Gerard J., Burkhardt, Amanda M., Hills, Rebecca, Rosenkilde, Mette M., Sparre-Ulrich, Alexander H., Combadiere, Christophe, Bachelerie, Francoise, Nibbs, Robert J. B., Uddin, Mohib, Monaghan, Amy E., Farber, Joshua M., Sozzani, Silvano, Mantovani, Alberto, Förster, Reinhold, Moschovakis, Georgios L., Charo, Israel F., Zlotnik, Albert, Thelen, Marcus, Horuk, Richard   +29 more
core   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Chemokine receptors and their interactors in HIV-1 replication: potential therapeutic targets [PDF]

, 2015
Chemokine receptors CXCR4 and CCR5 are co-receptors indispensable for human immunodeficiency virus type 1 (HIV-1) entry and subsequent infection in host cells.
Chuang Li, Yi-Jie Zhang, Denis J Dupré, Yi-Qun Kuang
core   +1 more source

Targeting Chemokines and Chemokine Receptors in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Journal of Inflammation Research, 2020
Sarah Dhaiban, Mena Al-Ani, Noha Mousaad Elemam, Azzam A Maghazachi College of Medicine and Immuno-Oncology Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab EmiratesCorrespondence: Azzam A MaghazachiDepartment of
Dhaiban S, Al-Ani M, Elemam NM, Maghazachi AA   +3 more
doaj  

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source