Results 131 to 140 of about 174,841 (260)

The effects of high-intensity interval training on NLRP3 inflammasome and monocyte chemokine receptors in individuals with obesity. [PDF]

PLoS One
Silveira ALPA, de Abreu DA, Musto ALS, Nali LHDS, do Amaral JB, Bachi ALL, Neves LM, Gil S, Santos FM, Victor JR, Shio MT, França CN.   +11 more
europepmc   +1 more source

Chemokines / Chemokine Receptors [PDF]

Mucosal Immunology, 2009
openaire   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Pharmacological and Genetic Targeting of Inflammatory Chemokine Receptors CCR1, CCR2, and CCR5 in Atherosclerosis: A Systematic Review and Meta-Analysis of Preclinical Studies. [PDF]

J Am Heart Assoc
Shoaran M, Caiazzo E, Morsy MI, Gurgone D, MacRitchie N, Bruzzese D, Ialenti A, Guzik TJ, Graham GJ, Maffia P.   +9 more
europepmc   +1 more source

Regulation of Tumor and Metastasis Initiation by Chemokine Receptors. [PDF]

J Cancer, 2022
DiNatale A, Castelli MS, Nash B, Meucci O, Fatatis A.   +4 more
europepmc   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Suppressive effects on metastasis and tumor growth by the knockout of chemokine receptors in a canine cutaneous lymphoma model. [PDF]

J Vet Med Sci
Kanei T, Murakami M, Yagi H, Ueda H, Mizuno T, Iwata M, Kamishina H, Maeda S.   +7 more
europepmc   +1 more source

IL-2 can signal via chemokine receptors to promote regulatory T cells' suppressive function. [PDF]

Cell Rep, 2023
Sun H, Lee HS, Kim SH, Fernandes de Lima M, Gingras AR, Du Q, McLaughlin W, Ablack J, Lopez-Ramirez MA, Lagarrigue F, Fan Z, Chang JT, VanDyke D, Spangler JB, Ginsberg MH.   +14 more
europepmc   +1 more source

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

Progress in structure-based drug development targeting chemokine receptors. [PDF]

Front Pharmacol
Wang J, Qu C, Xiao P, Liu S, Sun JP, Ping YQ.   +5 more
europepmc   +1 more source