Results 211 to 220 of about 174,841 (260)

Chemokine–Chemokine Receptors in Cancer Immunotherapy

Immunotherapy, 2008
A surge in interest in the chemokine-chemokine receptor network is probably related to the expanding roles that chemokines have now been identified to play in human biology, particularly immunity. Specific tissue microenvironments express distinct chemokines and both hematopoietic and nonhematopoietic cells have receptor expression profiles that permit
J. Stewart, Trina, J. Smyth, Mark
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Chemokines, Chemokine Receptors and Allergy

International Archives of Allergy and Immunology, 2001
Chemokines are a group of cytokines that are responsible for the influx of blood cells, including T and B lymphocytes, monocytes, neutrophils, eosinophils and basophils, in allergic and other inflammatory conditions. They function as G protein-coupled chemotactic factors which also activate the cells with which they interact.
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Chemokines and Chemokine Receptors in Scleroderma

International Archives of Allergy and Immunology, 2006
Scleroderma is a connective tissue disease with unknown etiology characterized by excessive deposition of extracellular matrix in the skin. Cellular infiltrates of certain immune cells and proinflammatory mediators are suggested to play a crucial role in cutaneous fibrosis, forming complicated networks between fibroblasts and immune cells via cell-cell
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Chemokines and chemokine receptors in rheumatoid arthritis

Seminars in Immunology, 2003
Chemokines are chemotactic cytokines involved in a number of pathological processes, including inflammatory conditions. Chemokines play a role in the pathogenesis of various inflammatory diseases. Based on a burgeoning body of literature, RA was chosen as a prototype to discuss this issue. In this review, the authors give a detailed introduction to the
Zoltán, Szekanecz, Joon, Kim, Alisa E, Koch   +2 more
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Chemokines, chemokine receptors and pain

Trends in Immunology, 2005
Many patients suffer from neuropathic pain as a result of injury to the peripheral nervous system (e.g. post-herpetic neuralgia or diabetic neuropathy) or to the central nervous system (e.g. spinal cord injury or stroke). The most distinctive symptom of neuropathic pain is allodynia, whereby normally non-painful stimuli, such as light touch, become ...
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Chemokine sequestration by atypical chemokine receptors

Biochemical Society Transactions, 2006
Leucocyte migration is essential for robust immune and inflammatory responses, and plays a critical role in many human diseases. Chemokines, a family of small secreted protein chemoattractants, are of fundamental importance in this process, directing leucocyte trafficking by signalling through heptahelical G-protein-coupled receptors expressed by the ...
C A H, Hansell, C V, Simpson, R J B, Nibbs   +2 more
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Targeting chemokines and chemokine receptors with antibodies

Drug Discovery Today: Technologies, 2012
Chemokines and their receptors are highly interesting therapeutic targets for pharmaceutical and biotechnology companies. In particular, industrial development pipelines are filled with new chemokine-targeting drugs to treat inflammatory diseases and malignancies.
Klarenbeek, A., Maussang, D., Blanchetot, C., Saunders, M., van der Woning, S.P., Smit, M.J., Haard, H., Hofman, E.   +7 more
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Chemokines and chemokine receptors in renal pathology

Current Opinion in Nephrology and Hypertension, 2003
Chemokines are members of the largest group of chemotactic cytokines, and were the first shown to be able to engage specific subpopulations of inflammatory cells. Accordingly, our expanding knowledge in chemokine biology has enlarged our understanding of inflammatory cell interactions, lymphopoesis, specificity of cell recruitment, and a variety of ...
Stephan, Segerer, Charles E, Alpers
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Chemokines and Chemokine Receptors Encoded by Cytomegaloviruses

2008
CMVs carry several genes that are homologous to genes of the host organism. These include genes homologous to those encoding chemokines (CKs) and G protein-coupled receptors (GPCRs). It is generally assumed that these CMV genes were hijacked from the host genome during the long co-evolution of virus and host.
Beisser, PS, Lavreysen, H, Bruggeman, CA, Vink, Kees   +3 more
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Chemokines and Chemokine Receptors

1999
Classic chemoattractants include complement components, formyl peptides and leukotriene B4. In addition, various cytokines are able to elicit directional migration of leukocytes. While molecules such as monocyte-colony stimulating factor or tumor necrosis factor also exert chemotactic activity, the main chemotactic cytokines are a superfamily of ...
A. Mantovani, P. Allavena, C. Garlanda, S. Ramponi, C. Paganini, A. Vecchi, S. Sozzani   +6 more
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