Results 11 to 20 of about 99,546 (246)
Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain
Frontiers in Cellular Neuroscience, 2014 The development of neuropathic pain in response to peripheral nerve lesion for a large part depends on microglia located at the dorsal horn of the spinal cord.
Knut eBiber, Knut eBiber, Erik eBoddeke
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Hypoxia Alters the Expression of CC Chemokines and CC Chemokine Receptors in a Tumor–A Literature Review [PDF]
International Journal of Molecular Sciences, 2020 Hypoxia, i.e., oxygen deficiency condition, is one of the most important factors promoting the growth of tumors. Since its effect on the chemokine system is crucial in understanding the changes in the recruitment of cells to a tumor niche, in this review we have gathered all the available data about the impact of hypoxia on β chemokines.
Jan Korbecki +6 more
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Molecular determinants for CC-chemokine recognition by a poxvirus CC-chemokine inhibitor [PDF]
Proceedings of the National Academy of Sciences, 2001 Poxviruses express a family of secreted proteins that bind with high affinity to chemokines and antagonize the interaction with their cognate G protein-coupled receptors (GPCRs). These viral inhibitors are novel in structure and, unlike cellular chemokine receptors, are able to specifically interact with most, if not all, CC-chemokines.
B T, Seet +5 more
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The CC Chemokine Eotaxin (CCL11) Is a Partial Agonist of CC Chemokine Receptor 2b [PDF]
Journal of Biological Chemistry, 2001 Despite sharing considerable homology with the members of the monocyte chemoattractant protein (MCP) family, the CC chemokine eotaxin (CCL11) has previously been reported to signal exclusively via the receptor CC chemokine receptor 3 (CCR3). Using the monocyte cell line THP-1, we investigated the relative abilities of eotaxin and MCPs 1-4 to induce ...
R, Martinelli +4 more
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Biomedicines, 2023 Cervical cancer (CC) is a serious global health issue, and it is well-known that HPV infection is the main etiological factor that triggers carcinogenesis.
Leonardo Fernandez-Avila +5 more
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Receptor-mediated Endocytosis of CC-chemokines [PDF]
Journal of Biological Chemistry, 1997 Chemokines are chemotactic proteins which play a central role in immune and inflammatory responses. Chemokine receptors are members of the seven transmembrane G-protein coupled family and have recently been shown to be involved in the entry of human immunodeficiency virus (HIV) into target cells.
R, Solari +7 more
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The Role of CC-Chemokines in the Regulation of Angiogenesis [PDF]
International Journal of Molecular Sciences, 2016 Angiogenesis, the formation of new blood vessels, is critical for survival and in the regenerative response to tissue injury or ischemia. However, in diseases such as cancer and atherosclerosis, inflammation can cause unregulated angiogenesis leading to excessive neovascularization, which exacerbates disease.
Anisyah Ridiandries +2 more
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CC chemokines and receptors in osteoarthritis: new insights and potential targets
Arthritis Research & Therapy, 2023 Osteoarthritis (OA) is a prevalent degenerative disease accompanied by the activation of innate and adaptive immune systems-associated inflammatory responses.
Yuchen Zhang +5 more
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Solution Structure of the Human CC Chemokine 2: A Monomeric Representative of the CC Chemokine Subtype, [PDF]
Biochemistry, 1999 HCC-2, a 66-amino acid residue human CC chemokine, was reported to induce chemotaxis on monocytes, T-lymphocytes, and eosinophils. The three-dimensional structure of HCC-2 has been determined by 1H nuclear magnetic resonance (NMR) spectroscopy and restrained molecular dynamics calculations on the basis of 871 experimental restraints.
H, Sticht +5 more
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Chemokine-induced phosphorylation of CC chemokine receptor 5 (CCR5) [PDF]
Journal of Leukocyte Biology, 1999 Abstract The CC-chemokine receptor 5 (CCR5) mediates activation of T lymphocytes and macrophages by chemokines and is a major co-receptor for macrophage-tropic HIV-1 strains. Recently, it was shown that the natural CCR5 ligands RANTES, macrophage inflammatory protein-1á (MIP-1á), MIP-1β, and amino-terminal modifications of RANTES (Met ...
H, Olbrich, A E, Proudfoot, M, Oppermann
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