Results 181 to 190 of about 19,998 (230)

CXC chemokines in angiogenesis of cancer

Seminars in Cancer Biology, 2004
The CXC chemokine family are unique cytokines known for their ability to have dual functions in the regulation of angiogenesis related to the following: (1) the presence or absence of the structural/functional motif (Glutamic acid-Leucine-Arginine; 'ELR' motif) that immediately precedes the first cysteine amino acid residue in the primary structure of ...
Robert M Strieter, John A Belperio, Roderick J Phillips   +2 more
exaly   +3 more sources

ELR+ CXC chemokines and their receptors (CXC chemokine receptor 1 and CXC chemokine receptor 2) as new therapeutic targets

Pharmacology & Therapeutics, 2006
ELR+ CXC chemokines, by direct interaction with their cell surface receptors CXC chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2 (CXCR2), are believed to be crucially involved in the direct migration and activation of leukocytes. ELR+ CXC chemokines are supposed to play a key role in several inflammatory diseases and this makes ELR+ CXC ...
Cinzia Bizzarri, Andrea R Beccari, Riccardo Bertini   +2 more
exaly   +3 more sources

The expression and role of CXC chemokines in colorectal cancer

Cytokine & Growth Factor Reviews, 2011
Cancer is a life-threatening disease world-wide and colorectal cancer is the second common cause of cancer mortality. The interaction between tumor cells and stromal cells plays a crucial role in tumor initiation and progression and is partially mediated by chemokines.
Hannelien, Verbeke, Sofie, Struyf, Geneviève, Laureys, Jo, Van Damme   +3 more
openaire   +3 more sources

Phylogenetic analysis of vertebrate CXC chemokines reveals novel lineage specific groups in teleost fish

Developmental and Comparative Immunology, 2013
In this study, we have identified 421 molecules across the vertebrate spectrum and propose a unified nomenclature for CXC chemokines in fish, amphibians and reptiles based on phylogenetic analysis.
Qiaoqing Xu, Tiehui Wang, Bertrand Collet   +2 more
exaly   +2 more sources

Three novel carp CXC chemokines are expressed early in ontogeny and at nonimmune sites

FEBS Journal, 2004
Three novel CXC chemokines were identified in common carp (Cyprinus carpio L.) through homology cloning. Phylogenetic analyses show that one of the three CXC chemokines is an unambiguous orthologue of CXCL14, whereas both others are orthologues of CXCL12,
Mark O Huising, Gert Flik, B M Lidy Verburg-Van Kemenade   +2 more
exaly   +2 more sources

Molecular evolution of CXC chemokines: extant CXC chemokines originate from the CNS

Trends in Immunology, 2003
The mammalian CXC chemokine system comprises 16 ligands and six receptors, and its actions stretch well beyond the immune system. Recent elucidation of the pufferfish genome, a representative of an evolutionary ancient vertebrate class, has enabled analysis of the mammalian CXC chemokine system in a phylogenetic context.
Huising, M.O., Stet, R.J.M., Kruiswijk, C.P., Savelkoul, H.F.J., Verburg-van Kemenade, B.M.L.   +4 more
openaire   +3 more sources

NOVEL CHICKEN CXC AND CC CHEMOKINES

Cytokine, 2000
Upon stimulation with lipopolysaccharide (LPS) the chicken macrophage cell line HD-11 secretes factors with cytokine activity. To characterize these molecules, representational difference analysis with RNA of LPS-induced and uninduced HD-11 cells was performed.
Sick, Christine, Schneider, Kirsten, Stäheli, Peter, Weining, Kirsten C.   +3 more
openaire   +3 more sources

THE ROLE OF CXC CHEMOKINES AS REGULATORS OF ANGIOGENESIS

Shock, 1995
The regulation of angiogenesis is fundamental to a variety of physiological and pathological processes. Although a number of factors have been identified that induce neovascularization, it is becoming increasingly apparent that endogenous angiostatic factors may play an important role in the regulation of angiogenesis during wound repair, chronic ...
R M, Strieter, P J, Polverini, D A, Arenberg, S L, Kunkel   +3 more
openaire   +2 more sources

The role of CXC chemokines and their receptors in cancer

Cancer Letters, 2008
Chemokines, or chemotactic cytokines, and their receptors have been discovered as essential and selective mediators in leukocyte migration to inflammatory sites and to secondary lymphoid organs. Besides their functions in the immune system, they also play a critical role in tumor initiation, promotion and progression.
Jo, Vandercappellen, Jo, Van Damme, Sofie, Struyf   +2 more
openaire   +2 more sources

CXC Chemokine Family

2022
Chemokines are a family of small, chemoattractant cytokines that play a central role in regulating the migration of cells into inflamed tissue. The CXC-chemokine sub-family is characterized by four cysteine amino acids that form two pairs of disulfide bridges, with the two cysteines proximal to the N-terminus separated by an additional amino acid (CXC).
openaire   +1 more source