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The role of CXC chemokine ligand 4/CXC chemokine receptor 3-B in breast cancer progression
Biotechnic & Histochemistry, 2018Chemokines and their receptors participate in the development of cancers by enhancing tumor cell proliferation, angiogenesis, invasion, metastasis and penetration of tumor immune cells. It remains unclear whether CXC chemokine ligand 4 (CXCL4)/CXC chemokine receptor 3-B (CXCR3-B) can be used as an independent molecular marker for establishing prognosis
R O, Saahene +4 more
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CXC Chemokines in Cancer Angiogenesis
2009Chemokines were first described for their ability to recruit leukocytes, but their biological role has now been recognized in many other biological processes. Angiogenesis, or the process of new blood vessel growth, is critical to many physiologic and pathologic processes, including tumorigenesis.
B. Mehrad, R. M. Strieter
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Constitutively Active Chemokine CXC Receptors
2014Chemokines are low-molecular-weight, secreted proteins that act as leukocyte-specific chemoattractants. The chemokine family has more than 40 members. Based on the position of two conserved cysteines in the N-terminal domain, chemokines can be divided into the CXC, C, CC, and CX3C subfamilies. The interaction of chemokines with their receptors mediates
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CXC chemokines and angiogenesis/angiostasis.
Proceedings of the Association of American Physicians, 1999Angiogenesis is important to a variety of physiological and pathological processes. While a variety of factors have been determined to regulate angiogenesis, members of the CXC chemokine family can either promote or inhibit this process. This disparity in biological behavior is due to the presence or absence of a structural-functional domain--three ...
M P, Keane +4 more
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The Biology of CXC Chemokines and Their Receptors
2005Publisher Summary This chapter explores the biology of CXC chemokines and their receptors. It also discusses the structure, function, and history of the CXC chemokine ligands and receptors. The chapter discusses the biochemistry and cell biology underlying the signaling of these molecules and elaborates the concept of cellular trafficking and the ...
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The Role of CXC Chemokines in Cancer Progression
Cancers, 2023Wannian Yang, Qiong Lin, Aiqin Sun
exaly
Tumor angiogenesis is regulated by CXC chemokines
Journal of Laboratory and Clinical Medicine, 1998B B, Moore +4 more
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