Results 191 to 200 of about 19,998 (230)
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ELR+ CXC chemokines in human milk
Cytokine, 2003CXC chemokines bearing the glutamic acid-leucine-arginine (ELR) motif are crucial mediators in neutrophil-dependent acute inflammation. Interestingly, however, Interleukin (IL)-8/CXC ligand (CXCL) 8 is expressed in human milk in biologically significant concentrations, and may play a local maturational role in the developing human intestine.
Akhil, Maheshwari +2 more
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The Journal of Immunology, 1998
Abstract IL-8 is one of the major mediators of the transendothelial migration of neutrophils from the circulation to the site of injury and infection. In this work we demonstrate that the CXC or α-chemokines, IL-8 and melanoma growth stimulatory activity (MGSA) induce myeloid suppression via direct action on progenitor cells, mediated by
X, Sanchez +4 more
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Abstract IL-8 is one of the major mediators of the transendothelial migration of neutrophils from the circulation to the site of injury and infection. In this work we demonstrate that the CXC or α-chemokines, IL-8 and melanoma growth stimulatory activity (MGSA) induce myeloid suppression via direct action on progenitor cells, mediated by
X, Sanchez +4 more
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CXC Chemokines in Angiogenesis Related to Pulmonary Fibrosis
Chest, 2002Angiogenesis, defined as the growth of new capillaries from preexisting vessels, is a pervasive biological phenomenon that is at the core of many physiologic and pathologic processes. An opposing balance of angiogenic and angiostatic factors regulates angiogenesis.
Robert M, Strieter +2 more
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The role of CXC chemokine ligand 4/CXC chemokine receptor 3-B in breast cancer progression
Biotechnic & Histochemistry, 2018Chemokines and their receptors participate in the development of cancers by enhancing tumor cell proliferation, angiogenesis, invasion, metastasis and penetration of tumor immune cells. It remains unclear whether CXC chemokine ligand 4 (CXCL4)/CXC chemokine receptor 3-B (CXCR3-B) can be used as an independent molecular marker for establishing prognosis
R O, Saahene +4 more
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The Emerging Role of CXC Chemokines And Their Receptors in Cancer
Future Medicinal Chemistry, 2012Chemokines and their receptors have a multifaceted role in tumor biology and are implicated in nearly all aspects of cancer growth, survival and dissemination. Modulation of the interaction between chemokines and their cell surface receptor is, therefore, a promising area for the development of new cancer medicines.
Victoria, Vinader, Kamyar, Afarinkia
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2005
Publisher Summary This chapter reviews the role that CXC chemokines play in mediating various events that are important and relevant to cancer. CXC chemokines can enhance innate and adaptive immunity, regulate angiogenesis, and mediate tumor‐cell metastases.
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Publisher Summary This chapter reviews the role that CXC chemokines play in mediating various events that are important and relevant to cancer. CXC chemokines can enhance innate and adaptive immunity, regulate angiogenesis, and mediate tumor‐cell metastases.
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Assignment of the mouse and cow CXC chemokine genes
Cytogenetic and Genome Research, 1998Gene specific PCR primers were constructed for five mouse and three bovine CXC chemokine genes. The mouse genes were assigned using SSCP analyses of the Jackson BSS backcross panel to two groups on chromosome 5. One group containing <i>Gro1</i> and <i>Mip2</i> cosegregated with reference markers <i>Alb1</i> and <i&
W S, Modi +4 more
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CXC Chemokines in Cancer Angiogenesis
2009Chemokines were first described for their ability to recruit leukocytes, but their biological role has now been recognized in many other biological processes. Angiogenesis, or the process of new blood vessel growth, is critical to many physiologic and pathologic processes, including tumorigenesis.
B. Mehrad, R. M. Strieter
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CXC Chemokines in Angiogenesis Relevant to Chronic Fibroproliferation
Current Drug Target -Inflammation & Allergy, 2005The CXC chemokines are an unique family of cytokines known for their ability to behave in a disparate manner in the regulation of angiogenesis. The mechanisms for the different activity in regulating angiogenesis by members of this chemokine family is related to the following: 1) the presence or absence of the structural/functional motif (Glutamic acid-
Robert M, Strieter +3 more
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Cancer CXC chemokine networks and tumour angiogenesis
European Journal of Cancer, 2006Chemokines have pleiotropic effects in regulating immunity, angiogenesis, stem cell trafficking, and mediating organ-specific metastases of cancer. In the context of angiogenesis, the CXC chemokine family is a unique group of cytokines known for their ability to behave in a disparate manner in the regulation of angiogenesis.
Robert M, Strieter +5 more
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