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Chemokine CXC Receptor 4: An Evolutionary Approach
Immunopharmacology and Immunotoxicology, 2006Selected segments of the nucleotide sequences of the human 18S rRNA and the human formyl peptide receptor 1 mRNA exhibit structural similarities that are unlikely to be due simply to chance. Herein we analyze the structural similarities between the human 18S rRNA gene and the vertebrate chemokine CXC receptor 4 (CXCR4) gene that encodes a class A ...
SISTO, MARGHERITA +5 more
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Constitutively Active Chemokine CXC Receptors
2014Chemokines are low-molecular-weight, secreted proteins that act as leukocyte-specific chemoattractants. The chemokine family has more than 40 members. Based on the position of two conserved cysteines in the N-terminal domain, chemokines can be divided into the CXC, C, CC, and CX3C subfamilies. The interaction of chemokines with their receptors mediates
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CXC chemokines and angiogenesis/angiostasis.
Proceedings of the Association of American Physicians, 1999Angiogenesis is important to a variety of physiological and pathological processes. While a variety of factors have been determined to regulate angiogenesis, members of the CXC chemokine family can either promote or inhibit this process. This disparity in biological behavior is due to the presence or absence of a structural-functional domain--three ...
M P, Keane +4 more
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Chemokines with CXC motif and their receptors in neuroendocrine neoplasms
Endocrine-Related CancerNeuroendocrine neoplasms (NENs) are challenging rare neoplasms not only for diagnosis but also for management. Immunotherapy has become a promising approach for NENs and clinical trials in phase I–II have been undertaken to evaluate the safety and efficacy of this treatment strategy.
Karolina Merecz +4 more
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The Biology of CXC Chemokines and Their Receptors
2005Publisher Summary This chapter explores the biology of CXC chemokines and their receptors. It also discusses the structure, function, and history of the CXC chemokine ligands and receptors. The chapter discusses the biochemistry and cell biology underlying the signaling of these molecules and elaborates the concept of cellular trafficking and the ...
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The Role of CXC Chemokines in Cancer Progression
Cancers, 2023Wannian Yang, Aiqin Sun, Qiong Lin
exaly
Tumor angiogenesis is regulated by CXC chemokines
Journal of Laboratory and Clinical Medicine, 1998B B, Moore +4 more
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The Role of CXC Chemokines in the Regulation of Angiogenesis
1999M P, Keane, R M, Strieter
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