Results 91 to 100 of about 455,922 (328)

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Chemokines, Chemokine Receptors and Atherosclerosis

, 2005
Publisher Summary This chapter focuses on chemokines, chemokine receptors, and atherosclerosis. Chemokines play essential roles in inflammation and disease. This family of inflammatory mediators has diverse roles in both immune and inflammatory responses, including the regulation of cellular recruitment, activation, and differentiation.
John, A, Channon, K, Greaves, D
openaire   +3 more sources

Chemokines, chemokine receptors and renal disease [PDF]

Kidney International, 1999
Chemokines are proinflammatory cytokines that function in leukocyte chemoattraction and activation. There are two major families of chemokines, termed CXC and CC, according to the presence or absence of an amino acid between a pair of cysteine residues near the NH2 terminal1,2.
openaire   +2 more sources

SensRORing cholesterol to drive protumoral myelopoiesis

Molecular Oncology, EarlyView.
Bleve et al. uncover a cholesterol‐driven immune evasion pathway, where RORγ‐dependent myelopoiesis shapes tumor immunosuppression. Targeting RORγ and PCSK9 emerges as a strategy to boost cancer immunotherapy. Protumoral myelopoiesis is a determinant of immunoevasion and tumor spread in many malignancies.
Sara Gennari, Luigi Nezi, Teresa Manzo
wiley   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

ISG20 promotes local tumor immunity and contributes to poor survival in human glioma

OncoImmunology, 2019
Recent evidence has confirmed that a mutation of the isocitrate dehydrogenase (IDH) gene occurs early in gliomagenesis and contributes to suppressed immunity.
Mengqi Gao, Yi Lin, Xing Liu, Yiming Li, Chuanbao Zhang, Zheng Wang, Zhiliang Wang, Yulin Wang, Zongze Guo   +8 more
doaj   +1 more source

Abdominal and Pelvic Organ Failure Induced by Intraperitoneal Influenza A Virus Infection in Mice

Frontiers in Microbiology, 2020
In humans, respiratory infections with influenza A viruses can be lethal, but it is unclear whether non-respiratory influenza A infections can be equally lethal.
Avishekh Gautam, Madhav Akauliya, Bikash Thapa, Byoung Kwon Park, Dongbum Kim, Jinsoo Kim, Keunwook Lee, Keunwook Lee, Kyung Chan Choi, Joon-Yong Bae, Man-Seong Park, Younghee Lee, Hyung-Joo Kwon, Hyung-Joo Kwon   +13 more
doaj   +1 more source

CXCL16/CXCR6 axis drives microglia/macrophages phenotype in physiological conditions and plays a crucial role in glioma [PDF]

, 2018
Microglia are patrolling cells that sense changes in the brain microenvironment and respond acquiring distinct phenotypes that can be either beneficial or detrimental for brain homeostasis.
Antonangeli, Fabrizio, D'Alessandro, Giuseppina, Esposito, Vincenzo, Lepore, Francesca, Limatola, Cristina, Santoro, Antonio, Trettel, Flavia   +6 more
core   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses [PDF]

, 2017
CXCR2 is an essential regulator of neutrophil recruitment to inflamed and damaged sites and plays prominent roles in inflammatory pathologies and cancer. It has therefore been highlighted as an important therapeutic target.
A Mantovani, A Rot, A Rot, A Zlotnik, A Zlotnik, AA Filardy, AE Cardona, AEI Proudfoot, C Schinke, D Marvel, DI Gabrilovich, F Bachelerie, F Balkwill, F Porcheray, F Sallusto, FR Balkwill, G Cacalano, H Saiwai, HM Baldwin, J Dalli, J Schindelin, J Yang, J-I Youn, J-I Youn, K Kishida, KM Hertzer, L Liu, M-C Lo, MK Ho, O Soehnlein, P Ranganathan, P Scapini, RA Navarro-Xavier, RM Devalaraja, S Milatovic, T Jamieson, T Jamieson, T Kakinuma, TJ Schall   +38 more
core   +1 more source