Results 301 to 310 of about 455,922 (328)
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Developmental & Comparative Immunology, 2004
Chemokines are small proteins that control cellular migration. An extensive family of these molecules has been described in mammals containing nearly 50 members. Within this family are four groups, each defined by the different spacing of two N-terminal cysteines, which form disulphide bonds with two other cysteine residues to create the tertiary ...
Kerry J, Laing, Christopher J, Secombes
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Chemokines are small proteins that control cellular migration. An extensive family of these molecules has been described in mammals containing nearly 50 members. Within this family are four groups, each defined by the different spacing of two N-terminal cysteines, which form disulphide bonds with two other cysteine residues to create the tertiary ...
Kerry J, Laing, Christopher J, Secombes
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Chemokines and Chemokine Receptors
1999Classic chemoattractants include complement components, formyl peptides and leukotriene B4. In addition, various cytokines are able to elicit directional migration of leukocytes. While molecules such as monocyte-colony stimulating factor or tumor necrosis factor also exert chemotactic activity, the main chemotactic cytokines are a superfamily of ...
Annunciata Vecchi +6 more
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Chemokine Receptors and Chemokines in HIV Infection
Journal of Clinical Immunology, 1998Suppression of HIV by chemokines represents a special case in virology and immunology where soluble molecules other than antibodies inhibit infection by a specific virus. The basis for this inhibition is that HIV has evolved to use certain chemokine receptors as "coreceptors" for entry into host cells.
GARZINO DEMO, ALFREDO +2 more
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2009
Tumor growth is restricted to approximately 2 microm diameters by simple dissociation of nutrients and oxygen. Hence, tumors require the formation of new blood vessels for further growth progression. This process is referred to as tumor neo-angiogenesis. The process of tumor neo-angiogenesis is directed by complex bidirectional interactions between the
Andreas, Hippe +2 more
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Tumor growth is restricted to approximately 2 microm diameters by simple dissociation of nutrients and oxygen. Hence, tumors require the formation of new blood vessels for further growth progression. This process is referred to as tumor neo-angiogenesis. The process of tumor neo-angiogenesis is directed by complex bidirectional interactions between the
Andreas, Hippe +2 more
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Chemokine–Chemokine Receptors in Cancer Immunotherapy
Immunotherapy, 2008A surge in interest in the chemokine-chemokine receptor network is probably related to the expanding roles that chemokines have now been identified to play in human biology, particularly immunity. Specific tissue microenvironments express distinct chemokines and both hematopoietic and nonhematopoietic cells have receptor expression profiles that permit
J. Stewart, Trina, J. Smyth, Mark
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Introduction to Chemokines and Chemokine Antagonists
2004Chemokines are small, soluble proteins with four conserved cysteines (Baggiolini et al. 1994, 1997). They consist of about 70–130 amino acids yielding molecular weights in the range of 7–15 kDa, and are synthesized with a leader sequence of 20–25 amino acids, which is cleaved off before release.
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Chemokines, Chemokine Receptors and Allergy
International Archives of Allergy and Immunology, 2001Chemokines are a group of cytokines that are responsible for the influx of blood cells, including T and B lymphocytes, monocytes, neutrophils, eosinophils and basophils, in allergic and other inflammatory conditions. They function as G protein-coupled chemotactic factors which also activate the cells with which they interact.
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Chemokines and Chemokine Receptors in Scleroderma
International Archives of Allergy and Immunology, 2006Scleroderma is a connective tissue disease with unknown etiology characterized by excessive deposition of extracellular matrix in the skin. Cellular infiltrates of certain immune cells and proinflammatory mediators are suggested to play a crucial role in cutaneous fibrosis, forming complicated networks between fibroblasts and immune cells via cell-cell
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Chemokines and chemokine receptors
2009There is a structural and a functional classification of chemokines. The former includes four groups: CXC, CC, C and CX3C chemokines. There is a redundancy and binding promiscuity between chemokine receptors and their ligands. Recently, a functional classification distinguishing between inflammatory and homeostatic chemokines has been introduced ...
Zoltán Szekanecz, Alisa E. Koch
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Targeting chemokines and chemokine receptors with antibodies
Drug Discovery Today: Technologies, 2012Chemokines and their receptors are highly interesting therapeutic targets for pharmaceutical and biotechnology companies. In particular, industrial development pipelines are filled with new chemokine-targeting drugs to treat inflammatory diseases and malignancies.
Christophe Blanchetot +7 more
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