Effectiveness of Seasonal Malaria Chemoprevention in children under 10 years of age in Senegal: a stepped-wedge cluster-randomized trial [PDF]
, 2016 This study was done to determine the effectiveness of Seasonal Malaria Chemoprevention in Senegalese children up to 10 years of age using a stepped-wedge design.
Milligan, Paul
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EBioMedicine, 2015 ERBB2 is an oncogenic receptor tyrosine kinase overexpressed in a subset of human breast cancer and other cancers. We recently found that human prolidase (PEPD), a dipeptidase, is a high affinity ERBB2 ligand and cross-links two ERBB2 monomers.
Lu Yang +3 more
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BMC Women's Health, 2021 Background Chemoprevention is one of several methods that have been developed to help high-risk women reduce their risk of breast cancer. Reasons for the low uptake of chemoprevention are poorly understood. This paper seeks a deeper understanding of this
Tasleem J. Padamsee +2 more
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The dynamics of gene expression changes in a mouse model of oral tumorigenesis may help refine prevention and treatment strategies in patients with oral cancer. [PDF]
, 2016 A better understanding of the dynamics of molecular changes occurring during the early stages of oral tumorigenesis may help refine prevention and treatment strategies.
Bertolus, Chloé +14 more
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Two Active Compounds from Caesalpinia sappan L. in Combination with Cisplatin Synergistically Induce Apoptosis and Cell Cycle Arrest on WiDr Cells [PDF]
Advanced Pharmaceutical Bulletin, 2017 Purpose: The aim of this study is to observe the synergistic effect of two active compounds of secang, brazilin and brazilein, combined with cisplatin on WiDr colon cancer cells. Methods: Cytotoxic activities of brazilin (Bi) and brazilein (Be) in single
Sri Handayani +3 more
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CEP55 Inhibitor: Extensive Computational Approach Defining a New Target of Cell Cycle Machinery Agent [PDF]
Advanced Pharmaceutical Bulletin, 2022 Purpose: Centrosomal protein 55 (CEP55) is a pivotal protein for cytokinesis during cell division. This study aimed to provide a comprehensive information about the CEP55 gene, including its expression pattern in several cancer types, conduct functional ...
Beni Lestari, Rohmad Yudi Utomo
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Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer. [PDF]
, 2014 Preventing breast cancer is an effective strategy for reducing breast cancer deaths. The purpose of chemoprevention (also termed preventive therapy) is to reduce cancer incidence by use of natural, synthetic, or biological agents.
Brown, Powel H, Litzenburger, Beate C
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Ornithine decarboxylase activity, a clinical biomarker for evaluating cancer chemopreventive efficacy of phytomolecules [PDF]
, 2011 Biomarkers of cancer have made a strong traipse in predicting the disease pattern and contributed significantly to the understanding of tumour state, progression, characteristics and response to therapies.
Nusrat Masood +2 more
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Feasibility of recruitment to an oral dysplasia trial in the United Kingdom [PDF]
, 2012 Background: Oral epithelial dysplasia (OED) has a malignant potential. Therapeutic options for OED remain both limited and without good evidence. Despite surgery being the most common method of treating OED, recurrence and potentially significant ...
Dunn, Janet A. +3 more
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PGV-1 Causes Disarrangement of Spindle Microtubule Organization Resulting in Aberrant Mitosis in HLF and HuH6 Cells Associated with Altered MYCN Status [PDF]
Advanced Pharmaceutical BulletinPurpose: The HLF and HuH-6 cell lines represent hepatocellular carcinoma (HCC) with different characteristics in chromosome content that may give different drug responses. Here, PGV-1 was intended to challenge the growth-suppressing effect on HLF and HuH-
Nadzifa Nugraheni +8 more
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