Mitochondrial Redox Signaling in O2-Sensing Chemoreceptor Cells
Antioxidants & Redox Signaling, 2022 Significance: Acute responses to hypoxia are essential for the survival of mammals. The carotid body (CB), the main arterial chemoreceptor, contains glomus cells with oxygen (O2)-sensitive K+ channels, which are inhibited during hypoxia to trigger adaptive cardiorespiratory reflexes.
Lin Gao +3 more
openaire +4 more sources
Vascular control of the CO2/H+-dependent drive to breathe
eLife, 2020 Respiratory chemoreceptors regulate breathing in response to changes in tissue CO2/H+. Blood flow is a fundamental determinant of tissue CO2/H+, yet little is known regarding how regulation of vascular tone in chemoreceptor regions contributes to ...
Colin M Cleary +5 more
doaj +1 more source
Unilateral Carotid Body Tumour: A Case Report [PDF]
Journal of Clinical and Diagnostic Research, 2023 The carotid body, which is located bilaterally on the medial side of the carotid bifurcation, is the largest group of paraganglia in the head and neck.
Shakti Sagar +4 more
doaj +1 more source
Interactions of chemostimuli at the single cell level: studies in a model system [PDF]
, 2004 The responses of afferent chemosensory fibres of the carotid body to individual chemostimuli have long been established. However, the mechanisms underlying the multiplicative interactions of these stimuli (i.e.
Peers, C.
core +1 more source
Structure and dynamics of the E. coli chemotaxis core signaling complex by cryo-electron tomography and molecular simulations [PDF]
, 2020 To enable the processing of chemical gradients, chemotactic bacteria possess large arrays of transmembrane chemoreceptors, the histidine kinase CheA, and the adaptor protein CheW, organized as coupled core-signaling units (CSU). Despite decades of study,
Cassidy, Keith +8 more
core +1 more source
Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors [PDF]
, 2001 Airway neuroepithelial bodies sense changes in inspired O2, whereas arterial O2 levels are monitored primarily by the carotid body. Both respond to hypoxia by initiating corrective cardiorespiratory reflexes, thereby optimising gas exchange in the face ...
Kemp, P.J., Peers, C.
core +4 more sources
Hypoxic regulation of ion channel function and expression [PDF]
, 2002 Acute hypoxia regulates the activity of specific ion channels in a rapid and reversible manner. Such effects underlie appropriate cellular responses to hypoxia which are designed to initiate cardiorespiratory reflexes and contribute importantly to other ...
Peers, C.
core +1 more source
The carotid body as a therapeutic target for the treatment of sympathetically mediated diseases [PDF]
, 2013 [no ...
Abdala, Ana P +13 more
core +2 more sources
Defining Two Chemosensory Arrays in Shewanella oneidensis
Biomolecules, 2022 Shewanella oneidensis has 2 functional chemosensory systems named Che1 and Che3, and 27 chemoreceptors. Che3 is dedicated to chemotaxis while Che1 could be involved in RpoS post-translational regulation.
Emma M. Fortier +7 more
doaj +1 more source
Solitary chemoreceptor cell survival is independent of intact trigeminal innervation [PDF]
Journal of Comparative Neurology, 2008 AbstractNasal solitary chemoreceptor cells (SCCs) are a population of specialized chemosensory epithelial cells presumed to broaden trigeminal chemoreceptivity in mammals (Finger et al. [2003] Proc Natl Acad Sci USA 100:8981–8986). SCCs are innervated by peptidergic trigeminal nerve fibers (Finger et al.
Brian, Gulbransen +2 more
openaire +2 more sources