Results 21 to 30 of about 4,582 (179)

Cholinergic Chemotransmission and Anesthetic Drug Effects at the Carotid Bodies

Molecules, 2020
General anesthesia is obtained by administration of potent hypnotics, analgesics and muscle relaxants. Apart from their intended effects (loss of consciousness, pain relief and muscle relaxation), these agents profoundly affect the control of breathing ...
Maarten Honing, Chris Martini, Monique van Velzen, Marieke Niesters, Albert Dahan, Martijn Boon   +5 more
doaj   +1 more source

The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension [PDF]

, 2013
In the spontaneously hypertensive (SH) rat, hyperoxic inactivation of the carotid body (CB) produces a rapid and pronounced fall in both arterial pressure and renal sympathetic nerve activity (RSA).
Hendy, Emma B, Sobotka, Paul A, Pijacka, Wioletta, Moraes, Davi J A, Abdala, Ana P, Marvar, Paul, McBryde, Fiona D, Paton, Julian F R   +7 more
core   +1 more source

Prediction of the Chemoreflex Gain by Common Clinical Variables in Heart Failure. [PDF]

PLoS ONE, 2016
BACKGROUND:Peripheral and central chemoreflex sensitivity, assessed by the hypoxic or hypercapnic ventilatory response (HVR and HCVR, respectively), is enhanced in heart failure (HF) patients, is involved in the pathophysiology of the disease, and is ...
Gianluca Mirizzi, Alberto Giannoni, Andrea Ripoli, Giovanni Iudice, Francesca Bramanti, Michele Emdin, Claudio Passino   +6 more
doaj   +1 more source

Chronic intermittent hypoxia promotes glomerular hyperfiltration and potentiates hypoxia-evoked decreases in renal perfusion and PO2

Frontiers in Physiology, 2023
Introduction: Sleep apnea (SA) is highly prevalent in patients with chronic kidney disease and may contribute to the development and/or progression of this condition.
Kiefer W. Kious, Kalie A. Savage, Stephanie C. E. Twohey, Stephanie C. E. Twohey, Aubrey F. Highum, Andrew Philipose, Hugo S. Díaz, Hugo S. Díaz, Rodrigo Del Rio, Rodrigo Del Rio, James A. Lang, Sarah C. Clayton, Noah J. Marcus   +12 more
doaj   +1 more source

Nocturnal episodic hypoxia and chemoreflex responsiveness [PDF]

, 2006
Chemoreflex responsiveness in obstructive sleep apnoea (OSA) is enhanced when evening vs. morning responses are compared. Such changes result in a decrease in ventilatory stability during sleep.
Diep, Tu Tuan
core   +1 more source

Novel approaches: targeting sympathetic outflow in the carotid sinus

Blood Pressure, 2023
Uncontrolled hypertension drives the global burden of increased cardiovascular disease (CVD) morbidity and mortality. Although high blood pressure (BP) is treatable and preventable, only half of the patients with hypertension undergoing treatment have ...
Dagmara Hering, Krzysztof Narkiewicz
doaj   +1 more source

Central role of carotid body chemoreceptors in disordered breathing and cardiorenal dysfunction in chronic heart failure

Frontiers in Physiology, 2014
Oscillatory breathing patterns are observed in pre-term infants, patients with cardio-renal impairment, and in otherwise healthy humans exposed to high altitude.
Noah J Marcus, Rodrigo eDel Rio, Harold D Schultz   +2 more
doaj   +1 more source

Evolution and physiology of neural oxygen sensing

Frontiers in Physiology, 2014
Major evolutionary trends in animal physiology have been heavily influenced by atmospheric O2 levels. Amongst other important factors, the increase in atmospheric O2 which occurred in the Pre-Cambrian and the development of aerobic respiration beckoned ...
Kauê Machado Costa, Daniela eAccorsi-Mendonça, Davi J.A. Moraes, Benedito H Machado   +3 more
doaj   +1 more source

Effect of chronic ethanol exposure on rat ventilatory responses to hypoxia and hypercapnia

Clinics, 2014
OBJECTIVE: The effect of chronic ethanol exposure on chemoreflexes has not been extensively studied in experimental animals. Therefore, this study tested the hypothesis that known ethanol-induced autonomic, neuroendocrine and cardiovascular changes ...
João Paulo J. Sabino, Andreia Lopes da Silva, Leonardo B. Resstel, Jose Antunes-Rodrigues, Mogens L. Glass, Luiz G.S. Branco   +5 more
doaj   +1 more source

Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation

Scientific Reports, 2017
Recent studies demonstrated a critical functional connection between the autonomic (sympathetic and parasympathetic) nervous and the immune systems.
Fernanda Machado Santos-Almeida, Gean Domingos-Souza, César A. Meschiari, Laura Campos Fávaro, Christiane Becari, Jaci A. Castania, Alexandre Lopes, Thiago M. Cunha, Davi J. A. Moraes, Fernando Q. Cunha, Luis Ulloa, Alexandre Kanashiro, Geisa C. S. V. Tezini, Helio C. Salgado   +13 more
doaj   +1 more source