Results 131 to 140 of about 64,721 (205)

Correction: High Caveolin-1 mRNA expression in triple-negative breast cancer is associated with an aggressive tumor microenvironment, chemoresistance, and poor clinical outcome. [PDF]

PLoS One
Godina C, Khazaei S, Belting M, Vallon-Christersson J, Nodin B, Jirström K, Isaksson K, Bosch A, Jernström H.   +8 more
europepmc   +1 more source

IMPDH2's Central Role in Cellular Growth and Diseases: A Potential Therapeutic Target

Cell Proliferation, EarlyView.
IMPDH2 is a rate‐limiting enzyme in guanine nucleotide biosynthesis. It plays diverse roles in various physiological and pathological processes: nucleotide metabolism, inflammation, immune function, ribosomal stress. Structural or regulatory alterations in IMPDH2 are linked to significant health issues, and critical relevance in disease progression. We
Zheng Li, Yunpeng Zou, Jiayao Niu, Ying Zhang, Aohua Yang, Wenyu Lin, Jie Guo, Shuya Wang, Ronghan Liu   +8 more
wiley   +1 more source

Extrachromosomal Circular DNA in Cancer: Mechanisms and Clinical Applications

Cell Proliferation, EarlyView.
ABSTRACT Extrachromosomal circular DNA (eccDNA) has emerged as a critical area of cancer research due to its ubiquitous presence in tumour cells and significant role in tumorigenesis, progression and drug resistance. Recent studies demonstrate that eccDNA promotes cancer progression by influencing genomic instability, amplifying oncogenes, regulating ...
Jiajia Li, Peng Luo, Zhengrui Li, Qi Wang, Xufeng Huang, Keliang Wang, Ruo Wang, Runzhi Chen   +7 more
wiley   +1 more source

Impact of poorly controlled type II diabetes mellitus on chemoresistance in colorectal cancer. [PDF]

World J Gastroenterol
Gaur A, Maity R, Dhali A, Biswas J.
europepmc   +1 more source

Synergistical Induction of Apoptosis via Cold Atmospheric Plasma and Nanohydroxyapatite for Selective Inhibition of Oral Squamous Cell Carcinoma in Tumour Microenvironment

Cell Proliferation, EarlyView.
The synergistic effects of microwave‐induced CAP and pH‐responsive NH2‐nHA on OSCC cells were investigated, unveiling novel molecular mechanisms. The study highlights CAP+NH2‐nHA's dual action, inducing diverse apoptotic pathways and establishing a ROS‐Ca2+ amplifying loop, promising in cancer therapy.
Wenting Qi, Hanghang Liu, Huaze Liu, Yuxuan Guo, Li Wu, Chongyun Bao, Xian Liu   +6 more
wiley   +1 more source

A Truncated Mutation of TP53 Promotes Chemoresistance in Tongue Squamous Cell Carcinoma. [PDF]

Int J Mol Sci
Du X, Zheng J, Lu X, Zhang Y.
europepmc   +1 more source

Mechanistic Insights and Therapeutic Potentials of Ubiquitin‐Proteasome System in Non‐Small Cell Lung Cancer

Cell Proliferation, EarlyView.
Lung cancer development involves mechanisms like reduced EGFR/EGF ubiquitination driving cancer cell behaviors and immune evasion via loss of PD‐1/PD‐L1 ubiquitination. Balancing ubiquitination and deubiquitination may be a potential therapeutic strategy. ABSTRACT Non‐small cell lung cancer (NSCLC) remains a leading cause of cancer mortality.
Guangyao Zhou, Jiaxiong Tan, Pengpeng Zhang, Zhaokai Zhou, Lianmin Zhang, Zhenfa Zhang   +5 more
wiley   +1 more source

B Cell Activating Factor Induces Drug Resistance in Hairy Cell Leukemia Variant. [PDF]

Biomedicines
Fritz C, Feinberg D, Radhakrishnan A, Klatt K, Chan ER, Rock P, Burack R, Parameswaran R.   +7 more
europepmc   +1 more source

GANT61 Modulates Autophagy and Lipid Metabolism in Ovarian Cancer

Cell Proliferation, EarlyView.
GANT61 induced autophagy via the AKT pathway and promoted the accumulation of lipid droplets in both cell lines. The molecular mechanism behind this lipid accumulation appears to involve the mediation of SREBP1. Furthermore, the combination of GANT61 with CQ/Fatostatin significantly inhibited the proliferation and clonogenicity of SKOV3 and SKOV3PTX ...
Yibin Pan, Lingfeng Chen, Jinlu Shen, Shihao Hong, Xiaojing Guan, Xudong Ma, Rongrong Tang, Meifei Lu, Fangying Sun, Shanliang Shang, Yongdong Dai, Zhaokai Zhou, Songying Zhang, Jianhua Yang   +13 more
wiley   +1 more source

Exploring the therapeutic potential of "Zhi-Zhen" formula for oxaliplatin resistance in colorectal cancer: an integrated study combining UPLC-QTOF-MS/MS, bioinformatics, network pharmacology, and experimental validation. [PDF]

Front Med (Lausanne)
Li Y, Chen K, Li Q, Liu Q, Han H, Liu H, Wang S.   +6 more
europepmc   +1 more source