Results 151 to 160 of about 149,400 (379)

EMT Program is Dispensable for Metastasis but Induces Chemoresistance in Pancreatic Cancer

Nature, 2015
Diagnosis of pancreatic ductal adenocarcinoma (PDAC) is associated with a dismal prognosis despite current best therapies; therefore new treatment strategies are urgently required. Numerous studies have suggested that epithelial-to-mesenchymal transition
Xiaofeng Zheng, Julienne L. Carstens, Jiha Kim, Matthew Scheible, Judith Kaye, H. Sugimoto, Chia-Chin Wu, Valerie S. LeBleu, R. Kalluri   +8 more
semanticscholar   +1 more source

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li   +12 more
wiley   +1 more source

Some aspects of treatment, prophylaxis and chemoresistance of plasmodium falciparum malaria [PDF]

, 1986
Marcos Boulos, Sílvia Maria Di Santi, Luis Carlos Barradas Barata, Aluísio Augusto Cotrim Segurado, A P Dutra, Vera Lucia Fonseca de Camargo-Neves   +5 more
openalex   +1 more source

MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer

Oncogene, 2019
Chemotherapy is the preferred treatment for advanced stage gastric cancer (GC) patients and chemotherapy resistance is the major obstacle to effective cancer therapy.
Wanming He, B. Liang, Chunlin Wang, Shaowei Li, Yang Zhao, Qiong Huang, Zexian Liu, Z. Yao, Qijin Wu, W. Liao, Shuyi Zhang, Yajing Liu, Yi Xiang, Jia Liu, Min Shi   +14 more
semanticscholar   +1 more source

A Dual Approach with Organoid and CRISPR Screening Reveals ERCC6 as a Determinant of Cisplatin Resistance in Osteosarcoma

Advanced Science, EarlyView.
This study utilizes patient‐derived osteosarcoma organoids and CRISPR screening to identify ERCC6 and HNRNPM as key mediators of cisplatin resistance via the PI3K/AKT pathway and BAX alternative splicing. These findings provide novel insights and potential therapeutic targets for overcoming chemoresistance in osteosarcoma.
Ruiling Xu, Sai Zhu, Wenchao Zhang, Haodong Xu, Chao Tu, Honghui Wang, Lu Wang, Na He, Tang Liu, Xiaoning Guo, Xiaolei Ren, Zhihong Li   +11 more
wiley   +1 more source

Epigenetic regulation of CD271, a potential cancer stem cell marker associated with chemoresistance and metastatic capacity. [PDF]

, 2015
Cancer stem cells (CSCs) are considered to be the cause of tumor initiation, metastasis and recurrence. Additionally, CSCs are responsible for the failure of chemotherapy and radiotherapy.
Chen, Xinfeng, Gao, Qun, Huang, Lan, Li, Feng, Li, Jieyao, Li, Sulan, Ping, Yu, Wang, Dan, Wang, Liping, Yang, Li, Yue, Dongli, Zhang, Tengfei, Zhang, Yi   +12 more
core  

Association of Loss of Heterozygosity at the p53 Locus with Chemoresistance in Osteosarcomas [PDF]

, 1998
Akiteru Goto, Hiroaki Kanda, Yuichi Ishikawa, Seiichi Matsumoto, Noriyoshi Kawaguchi, Rikuo Machinami, Yo Kato, Tomoyuki Kitagawa   +7 more
openalex   +1 more source

EMT is not required for lung metastasis but contributes to chemoresistance

Nature, 2015
The role of epithelial-to-mesenchymal transition (EMT) in metastasis is a longstanding source of debate, largely owing to an inability to monitor transient and reversible EMT phenotypes in vivo.
Kari R. Fischer, A. Durrans, Sharrell B Lee, J. Sheng, Fuhai Li, Stephen T. C. Wong, Hyejin Choi, Tina El Rayes, S. Ryu, Juliane S. Troeger, R. Schwabe, L. Vahdat, N. Altorki, V. Mittal, Dingcheng Gao   +14 more
semanticscholar   +1 more source

Advanced Microfluidics for Single Cell‐Based Cancer Research

Advanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro, Marta Aranda Palomer, Margarida Esteves, Carolina Rodrigues, José Maria Fernandes, Francisca Oliveira, Alexandra Teixeira, Carlos Honrado, Lorena Dieguez, Sara Abalde‐Cela, Miguel Xavier   +10 more
wiley   +1 more source

HDAC10 in neuroblastoma chemoresistance

, 2019
Neuroblastoma is the most common extracranial solid tumor in childhood, and characteristically displays a wide variety of clinical outcomes. While prognosis is generally favorable in low-risk and intermediate-risk tumors, outcome remains poor in high-risk neuroblastoma, and infaust in case of relapse.
openaire   +2 more sources