Results 211 to 220 of about 149,400 (379)

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source

HSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanisms

Frontiers in Cell and Developmental Biology
Heat Shock Factor 1 (HSF1) is a major transcriptional factor regulating the heat shock response and has become a potential target for overcoming cancer chemoresistance. This review comprehensively examines HSF1’s role in chemoresistance and its potential
Shruti Ghai, Rejina Shrestha, Kuo-Hui Su
doaj   +1 more source

Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway

, 2001
Stéphane Lafarge, V. Sylvain, Marc Ferrara, Yves‐Jean Bignon   +3 more
openalex   +1 more source

m6A Methylation‐Induced Autophagy Impairment by TFEB Regulation in SOD1‐G93A ALS Cell Model

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT We investigate the role of m6A RNA methylation in regulating transcription factor EB (TFEB) and its contribution to mitochondrial autophagy (mitophagy) dysfunction in amyotrophic lateral sclerosis (ALS). ALS cell models were used to analyse mitophagy markers and TFEB expression under METTL3 and TFEB modulation, using RT‐qPCR, Western blot ...
Di An, Yuhao Wu, Jingzhe Han, Pingping Fang, Yi Bu, Guang Ji, Jinliang Deng, Xueqin Song   +7 more
wiley   +1 more source

HTRA1 interacts with SLC7A11 to modulate colorectal cancer chemosensitivity by inhibiting ferroptosis

Cell Death Discovery
Chemotherapy is an important therapuetic strategy for colorectal cancer (CRC), but chemoresistance severely affects its efficacy, and the underlying mechanism has not been fully elucidated.
Weiwei Liu, Chaoqun Liu, Jun Xiao, Cheng Qian, Zhilin Chen, Wandie Lin, Yujie Zhang, Jianghua Wu, Rui Zhou, Liang Zhao   +9 more
doaj   +1 more source

Active roles for inhibitory κB kinases α and β in nuclear factor-κB–mediated chemoresistance to doxorubicin [PDF]

, 2008
Brian K. Bednarski, Xiaoyu Ding, Kavita Coombe, Albert S. Baldwin, Hong Joo Kim   +4 more
openalex   +1 more source

HOXC11-mediated regulation of mitochondrial function modulates chemoresistance in colorectal cancer

BMC Cancer
Background Chemoresistance remains a significant challenge in colorectal cancer (CRC) treatment, necessitating a deeper understanding of its underlying mechanisms.
Shicheng Chu, Xiang Ren, Lianmeng Cao, Chong Ma, Kai Wang   +4 more
doaj   +1 more source

The Stem Cell Transcription Factor OCT4 Silences Target DNA Methyltransferase 1 to Strengthen DNA Damage Response in Cisplatin‐Treated Gastric Cancer Cells

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT OCT4 plays a crucial role in the DNA damage response(DDR) mechanism, whereas cisplatin (CDDP) acts as an anti‐tumor agent by inducing DDR. This study aimed to investigate the role of OCT4 in regulating DNA methyltransferase 1 (DNMT1) in CDDP‐treated gastric cancer (GC).
Zhengzheng Yan, Xiaoqian Bu, Haixia Chen, Chongren Ren, Ji Li, Yongjie Wu, Jun Xing   +6 more
wiley   +1 more source

Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells [PDF]

, 2008
David W. Chan, Vincent W.S. Liu, George S.W. Tsao, Kwok‐Ming Yao, Toru Furukawa, Karen K. L. Chan, Hys Ngan   +6 more
openalex   +1 more source

Mechanisms Involved in Chemoresistance in Ovarian Cancer

, 2005
Kar-San Ling, Gin‐Den Chen, Horng-Jyh Tsai, Maw‐Sheng Lee, Po-Hui Wang, Fu-Shing Liu   +5 more
openalex   +1 more source