COL3A1<sup>high</sup> cancer-associated fibroblasts orchestrate metabolic and immune microenvironments to confer chemoresistance in breast cancer. [PDF]
NPJ Precis OncolJiang P +7 more
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Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa +2 more
wiley +1 more source
ADDRESSING CHEMORESISTANCE IN LUNG CANCER: PATHWAYS AND THERAPEUTIC APPROACHES
Kaniga Pandi, Binoy Varghese Cheriyan
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Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research
Mass Spectrometry Reviews, EarlyView.Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik +3 more
wiley +1 more source
Chemoresistance of PRAME-expressing melanoma cell can be resolved with help of bortezomib
, 2019 V. A. Misyurin +11 more
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New compositions for the treatment of chemoresistant and/or potentially chemoresistant leukaemias
, 2009 SOMMARIO DELL'INVENZIONE L'invenzione della presente descrizione si basa sulla scoperta che la chemioresistenza in numerose forme leucemiche è eliminata o fortemente ridotta da un trattamento con almeno un composto per terapie antitumorali in combinazione con almeno un bloccante del canale di potassio hERG1.
ARCANGELI, ANNAROSA +4 more
openaire +2 more sources
Med Research, EarlyView.White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang +12 more
wiley +1 more source
Unraveling glutamine metabolism in ovarian carcinoma: signaling cross-talk, positron emission tomography utility, and therapeutic boundaries. [PDF]
Transl Cancer ResTong J.
europepmc +1 more source