Results 221 to 230 of about 99,790 (252)

Systems biology of Wnt signaling in glioma chemotherapy resistance: Integrating multi-omics mechanisms and emerging therapeutic vulnerabilities (Review). [PDF]

Oncol Lett
Zeng Q, Chen Z, Zhang R, Pan H.
europepmc   +1 more source

SERPINE1 Alternative Polyadenylation Influences Gastric Cancer Prognosis via N6‐Methyladenosine Modification

Cancer Science, EarlyView.
Multi‐omics integration of the transcriptomic APA landscape and m6A modifications identifies key prognostic genes. Their biological functions and molecular mechanisms in promoting tumor progression are comprehensively validated through in vitro assays. ABSTRACT Alternative polyadenylation (APA) and N6‐methyladenosine (m6A) methylation are critical post‐
Zhuoyi Wu, Ruyun Xu, Ju Fang, Bing Liu, Cao Zhang, Shangxin Zhang, Jing Ni   +6 more
wiley   +1 more source

Oncogenic EGFR Signaling as a Central Regulator of Chemoresistance in Ovarian Cancer: A Mechanistic Review. [PDF]

Int J Mol Sci
Nagappan A, Sethuraman V, Pandian P, Nedunchezhian J, Shukla AK.   +4 more
europepmc   +1 more source

YBX1 Promotes Malignant Progression of HNSCC via Stabilizing NSUN2‐m5C Modified ATF4 mRNA

Cancer Science, EarlyView.
The diagram depicts the core axis and the key finding: “Targeting YBX1/NSUN2 abrogates HNSCC progression”. Within left‐sided HNSCC cells, NSUN2 mediates m5C methylation on the CDS of ATF4 mRNA; YBX1 then specifically recognizes and binds this modified site, augmenting ATF4 mRNA stability, which ultimately promotes cancer cell proliferation, migration ...
Yanwei Li, Shuang Li, Yang Li, Zhanyu Pan   +3 more
wiley   +1 more source

Autophagy Modulation in Cancer Therapy: Navigating the Dual Roles to Overcome Chemoresistance. [PDF]

Health Sci Rep
Mohiuddin M, Ahsan MAM.
europepmc   +1 more source

Repression of ROBO1 Enhances Cisplatin Sensitivity in Hypermethylated Subtype of HPV‐Positive Head and Neck Carcinoma

Cancer Science, EarlyView.
DNA hypermethylation causally correlates with better treatment response of HPV(+) HNSCC, and its chemosensitivity might be enhanced by silencing of methylation target genes. Silencing of ROBO1 enhances, and its overexpression reduces, CDDP chemosensitivity, and epigenetic or ROBO1‐targeted interventions may improve therapeutic outcomes in resistant HPV(
Kenta Saeda, Takuya Nakagawa, Atsushi Okabe, Kazuko Kita, Tomoya Kurokawa, Masaki Fukuyo, Hiroki Ueda, Motoaki Seki, Bahityar Rahmutulla, Syuji Yonekura, Toyoyuki Hanazawa, Atsushi Kaneda   +11 more
wiley   +1 more source

Correction: Overcoming chemoresistance in esophageal cancer with synergistic strategies. [PDF]

Front Immunol
Gao C, Zhang T, Li G, Zhang W, Chen H, Li D, Xu J, Li M, Wang R, Xing Y, Zhan J, Ren Z, Xue X, Liang W, Sun X, Zhang X, Liang X, Zhan H, Zhang Z, Chu X.   +19 more
europepmc   +1 more source

Patient-Derived Organoid and Single-Cell Multiomics Reveal Evolution Driven by CEACAM6/KRT19-Mediated Heterogeneity. [PDF]

FASEB J
Jing C, Wang Z, Cao H, Zhang Y, Huang Y, Yu Y, Li B, Ma R.   +7 more
europepmc   +1 more source

ALDH2 regulates oxaliplatin sensitivity via PDE4B in p53-mutant colorectal cancer. [PDF]

Int J Med Sci
Wei PL, Huang CY, Lee CC, Batzorig U, Tsai KY, Chang YJ.   +5 more
europepmc   +1 more source

LSD1-GLS2 axis drives subtype-specific chemoresistance in pancreatic cancer through glutaminolysis reprogramming. [PDF]

Cell Death Dis
Wang Z, Huang Q, Zhao J, Lyu Z, Ju F, You B, Wang J, Dong Q, Odenthal M, Quaas A, Diakopoulos KN, Algül H, Reichert M, Bruns CJ, Zhao Y.   +14 more
europepmc   +1 more source