Results 231 to 240 of about 133,761 (337)

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Drug Repurposing Screen Identifies Pimozide as a ROS‐Inducing Therapy With Anti‐Tumor Efficacy in HNSCC PDX Models

Cancer Science, EarlyView.
A drug repurposing screen for reactive oxygen species (ROS)‐inducing compounds identified Pimozide as a potent anti‐tumor agent in head and neck squamous cell carcinoma (HNSCC) patient‐derived xenograft (PDX) models. Combined treatment with paclitaxel markedly reduced undifferentiated tumor cells.
Shogo Okazaki, Shintaro Nakamura, Tomoya Soma, Momoko Yoshikawa, Seiji Asoda, Yurika Nakajima, Kenji Tsuchihashi, Mitsuyo Ohmura, Ryo Goitsuka, Kenichi Imai, Hideyuki Saya, Osamu Nagano, Hiroyuki Ozawa   +12 more
wiley   +1 more source

Antileukemic Potential of Sodium Caseinate in Cytarabine-Resistant HL60-CR50 Human Leukemia Cells. [PDF]

Molecules
Santiago-Osorio E, Romero-Trejo D, Macías-Zaragoza VM, Rodríguez-Terán KM, Mendoza-Núñez VM, Sierra-Mondragón E, Romero-López E, Shira L, Hernández-Álvarez D, Aguiñiga-Sánchez I.   +9 more
europepmc   +1 more source

Regulation of R‐Loop Dynamics by Proteins and Long Noncoding RNAs: An Emerging Paradigm for Cancer Treatment

Cancer Science, EarlyView.
R‐loops are three‐stranded nucleic acid structures whose dysregulation leads to genomic instability and cancer progression. This review summarizes the protein and lncRNA machineries that regulate R‐loop dynamics and discusses the therapeutic potential of targeting these pathways in cancer.
Miho M. Suzuki, Keiko Shinjo, Tatsunori Nishimura, Yutaka Kondo   +3 more
wiley   +1 more source

FUT3-B3GNT3 interaction promotes pancreatic cancer progression and chemoresistance via NF-κB signaling mediated autophagy. [PDF]

Eur J Med Res
Jin L, Han W, Zou J, Tang X, Chen P, Xie H, Zhou B, Qian D, Yu Y.   +8 more
europepmc   +1 more source

New compositions for the treatment of chemoresistant and/or potentially chemoresistant leukaemias

, 2009
SOMMARIO DELL'INVENZIONE L'invenzione della presente descrizione si basa sulla scoperta che la chemioresistenza in numerose forme leucemiche è eliminata o fortemente ridotta da un trattamento con almeno un composto per terapie antitumorali in combinazione con almeno un bloccante del canale di potassio hERG1.
ARCANGELI, ANNAROSA, Becchetti A., PILLOZZI, SERENA, MASSELLI, MARIKA, DE LORENZO, EMANUELE   +4 more
openaire   +2 more sources

Impacts of Mitochondrial Status After Neoadjuvant Chemotherapy in Esophageal Squamous Cell Carcinoma Patients

Cancer Science, EarlyView.
We described the prognostic impacts of mitochondrial status after neoadjuvant chemotherapy and its association with the tumor microenvironment in esophageal squamous cell carcinoma patients. High Mito‐score after NAC identifies ESCC patients with significantly poorer survival, particularly among those with advanced pathological stages, thereby possibly
Kotaro Sugawara, Shingo Sakashita, Takashi Fukuda, Chiaki Murakami, Daiji Oka, Gulanbar Amori, Yoshifumi Baba, Hiroaki Kanda, Noriko Motoi   +8 more
wiley   +1 more source

YTHDF1 targets the chemotherapy response by suppressing NOTCH1-induced stemness in colorectal cancer. [PDF]

Signal Transduct Target Ther
Cheung H, Chen H, Chen D, Zhou H, Liang C, Liu W, Cheung AH, Ding Y, Yuan K, Li X, Zhang Y, Wang S, Kang W, To KF, He H, Wong CC, Yu J.   +16 more
europepmc   +1 more source

Correction to “Terpenoids From Quinoa Reverse Chemoresistance in Breast Cancer by Suppressing the Stemness‐Related lncRNA 667012”

Food Frontiers, EarlyView.
wiley   +1 more source

MASTL Promotes Hepatocellular Carcinoma Progression and Paclitaxel Resistance Through Mitotic Catastrophe

Cancer Science, EarlyView.
MASTL drives hepatocellular carcinoma (HCC) progression and paclitaxel resistance by triggering mitotic catastrophe. Depletion of MASTL induces DNA damage and promotes mitotic catastrophe, leading to cell death in HCC. MASTL‐mediated mitotic catastrophe depends on PP2A‐B55α activity, suggesting a novel therapeutic target for overcoming chemotherapy ...
Ke Wang, Ziwei Fu, Chuan Xiong, Jing Zhang, Qiang Luo   +4 more
wiley   +1 more source