Results 311 to 320 of about 149,400 (379)

A Truncated Mutation of TP53 Promotes Chemoresistance in Tongue Squamous Cell Carcinoma. [PDF]

Int J Mol Sci
Du X, Zheng J, Lu X, Zhang Y.
europepmc   +1 more source

Reversal of MPPa‐PDT Resistance in Osteosarcoma by Targeting ROCK2‐Mediated Autophagy

Cell Proliferation, EarlyView.
ROCK2 competes with MST1 to bind to the aa 28‐198 region of SAV1 and then regulates the Hippo pathway to affect autophagy, resulting in the resistance of OS to MPPa‐PDT. Targeted inhibition of ROCK2 by screening for J059‐0149 increases the sensitivity of osteosarcoma to MPPa‐PDT. ABSTRACT Osteosarcoma (OS) is a primary bone tumour that occurs mostly in
Xuan Yi, Xueqiang Deng, Jianyong Deng, Chen Li, Hong Peng, Yunyan Du, Qing Li, Xiaohua Yan, Xin Hu, Yan Zheng, Shenliang Chen, Ting Xiong, Debin Xu, Leifeng Chen, Liang Hao   +14 more
wiley   +1 more source

Chemoresistant tumor cell secretome potentiates immune suppression in triple negative breast cancer. [PDF]

Breast Cancer Res
Skourti E, Seip K, Mensali N, Jabeen S, Juell S, Øynebråten I, Pettersen S, Engebraaten O, Corthay A, Inderberg EM, Dolznig H, Mælandsmo GM, Egeland EV, Prasmickaite L.   +13 more
europepmc   +1 more source

Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application

The FEBS Journal, EarlyView.
Multiple myeloma is characterised by the clonal proliferation of plasma cells in the bone marrow. Extracellular vesicles (EVs) are a key component of cell‐to‐cell communication within the bone marrow microenvironment, promoting tumour growth, bone remodelling, immune modulation, angiogenesis and therapeutic resistance.
Chloe Wylie, Rebecca Rowan, Dessi Malinova, Lisa Crawford   +3 more
wiley   +1 more source

Correction: High Caveolin-1 mRNA expression in triple-negative breast cancer is associated with an aggressive tumor microenvironment, chemoresistance, and poor clinical outcome. [PDF]

PLoS One
Godina C, Khazaei S, Belting M, Vallon-Christersson J, Nodin B, Jirström K, Isaksson K, Bosch A, Jernström H.   +8 more
europepmc   +1 more source

Acquisition of Chemoresistance in Gliomas Is Associated with Increased Mitochondrial Coupling and Decreased ROS Production

, 2011
Claudia R. Oliva, Douglas R. Moellering, G. Yancey Gillespie, Corinne E. Griguer   +3 more
openalex   +2 more sources

ZNF224 enhances the oncogenic function of p21 via p53 and AKT pathways in melanoma

The FEBS Journal, EarlyView.
KRAB zinc finger protein ZNF224 acts as an oncogenic factor in melanoma cells, enhancing p21 cytosolic retention and impairing nuclear p21 cytostatic activity through stimulation of the AKT pathway. Furthermore, ZNF224 regulates transcriptional expression levels of p21 via p53.
Leandra Sepe, Umberto Candia, Dario Sasso del Verme, Elvira Toscano, Marianna Toriello, Gaetano Sodaro, Roberta Rapuano, Simona Romano, Michela Grosso, Giovanni Paolella, Angelo Lupo, Paola Costanzo, Elena Cesaro   +12 more
wiley   +1 more source

Dexamethasone, celecoxib, and simvastatin-induced 5-fluorouracil resistance in cancer cells: a possible role of lipid droplet accumulation. [PDF]

Discov Oncol
Sabbah DS, Ikhmais BA, Abdallah QM, Phillips RM, Qinna NA.   +4 more
europepmc   +1 more source

The Rab25‐ADAMTS5 axis as a previously undescribed mechanism for sensing tumor microenvironment complexity

The FEBS Journal, EarlyView.
The tumor microenvironment (TME), particularly the extracellular matrix (ECM), plays a critical role in cancer progression. Focusing on ovarian cancer, Yuan et al. reveal an ECM‐dependent signaling axis where cancer‐associated fibroblasts (CAFs) enhance the invasiveness of cancer cells via Rab25‐driven upregulation of the protease ADAMTS5. This process
François Tyckaert, Francesco Baschieri
wiley   +1 more source

B Cell Activating Factor Induces Drug Resistance in Hairy Cell Leukemia Variant. [PDF]

Biomedicines
Fritz C, Feinberg D, Radhakrishnan A, Klatt K, Chan ER, Rock P, Burack R, Parameswaran R.   +7 more
europepmc   +1 more source