Results 331 to 340 of about 149,400 (379)

Extracellular vesicle-mediated chemoresistance in breast cancer: focus on miRNA cargo. [PDF]

Extracell Vesicles Circ Nucl Acids
Ciferri MC, Tasso R.
europepmc   +1 more source

Identification of potential cell surface targets in patient‐derived cultures toward photoimmunotherapy of high‐grade serous ovarian cancer

Photochemistry and Photobiology, EarlyView.
Through mRNA sequencing, proteomics, and flow cytometry, we identified potential cell surface targets toward tumor‐targeted, activatable photoimmunotherapy (taPIT) in advanced high‐grade serous ovarian cancers (HGSOCs) with low EGFR expression. The reliance on EGFR overexpression has been a major limitation of taPIT, which this study seeks to address ...
Sudip Timilsina, Anish Raju Amara, Rafay Abu, Bryan Q. Spring   +3 more
wiley   +1 more source

The Landscape of Cancer Metabolism as a Therapeutic Target

Pathology International, EarlyView.
ABSTRACT Cancer cells reprogram their metabolism during progression to adapt to the tumor microenvironment, which is characterized by distinct differences in nutrient availability, oxygen concentrations, and acidity. This metabolic reprogramming can simultaneously create metabolic vulnerabilities unique to cancer cells, making cancer metabolism a ...
Kenji Ohshima
wiley   +1 more source

Potent Therapeutic Activity of NEO212 in Preclinical Models of Human and Canine Leukaemia and Lymphoma

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Haematological cancer types, such as leukaemia and lymphoma, represent diseases that are life‐threatening to canine and human patients alike, and better treatments are needed. We are developing a novel anticancer agent, NEO212, a conjugate of two cancer drugs, the alkylating agent temozolomide (TMZ) and the monoterpene perillyl alcohol (POH ...
Thomas C. Chen, Steve Swenson, Thu Zan Thein, Radu O. Minea, Axel H. Schönthal   +4 more
wiley   +1 more source

TMEM160 inhibits KEAP1 to suppress ferroptosis and induce chemoresistance in gastric cancer. [PDF]

Cell Death Dis
Huang C, Zeng Q, Chen J, Wen Q, Jin W, Dai X, Ruan R, Zhong H, Xia Y, Wu Z, Huang R, Zhang J, Yao Y, Li L, Lei W, Xiong J, Deng J.   +16 more
europepmc   +1 more source

Transferrin Receptor‐1: Expression in Canine Mammary Tumours and In Vitro Therapeutic Applications

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT The transferrin receptor‐1 (TFR‐1) is overexpressed in many types of human cancers and, in recent years, several studies have investigated its use as a preferential channel for drug cellular uptake in cancer therapy. In veterinary medicine, TFR‐1 expression in cancer cells and tissues has been poorly described, as well as its therapeutic ...
Valentina Moccia, Nicolò Rensi, Giovanni Paolo Marullo, Alessandro Sammarco, Federico Bonsembiante, Filippo Torrigiani, Lucia Salvioni, Davide Prosperi, Valentina Zappulli, Laura Cavicchioli   +9 more
wiley   +1 more source

Expression of concern: "A miR-567-PIK3AP1-PI3K/AKT-c-Myc feedback loop regulates tumour growth and chemoresistance in gastric cancer" [eBioMedicine Volume 44, Pages 311-321 June 2019, 2147]. [PDF]

EBioMedicine
europepmc   +1 more source

Bufalin targets the SRC-3/c-Myc pathway in chemoresistant cells to regulate metastasis induced by chemoresistance in colorectal cancer. [PDF]

J Cancer Res Clin Oncol
Chen J, Wu C, Yu K, Liu J, Yang J, Li W, Tang X, Shi Y, Xu K, Chen Y, Qin X.   +10 more
europepmc   +1 more source

Dose and Duration of Upfront Steroid Administration Have no Prognostic Impact in Dogs With Multicentric Diffuse Large B‐Cell Lymphoma

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Steroids provide rapid clinical improvement in dogs with multicentric diffuse large B‐cell lymphoma (DLBCL). However, their use before chemotherapy can induce chemoresistance and compromise diagnostic yield due to increased apoptotic cells.
Ilaria Maga, Silvia Sabattini, Valeria Martini, Fulvio Riondato, Luca Aresu, Laura Marconato   +5 more
wiley   +1 more source

IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma. [PDF]

Cell Mol Life Sci
Zhang S, Gu M, Yin H, Pan S, Xie H, Chen W, Gul S, Zhao Y, Wang Z, Zheng W, You Y, You B.   +11 more
europepmc   +1 more source