Results 181 to 190 of about 65,117 (210)
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Chemotaxis of polymorphonuclear leukocytes
Biochemical Pharmacology, 1968Abstract Chemotaxis of polymorphonuclear leukocytes (PMN) has been studied by the use of chambers with micropore filters. This technique measures the specific, unidirectional migration of PMN toward an attractant. The nature of the medium in which the cells are suspended is important because homologous serum considerably increases cell responsiveness
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Roles of PI3Ks in leukocyte chemotaxis and phagocytosis
Current Opinion in Cell Biology, 2002Through selective disruption of phosphoinositide 3-kinase (PI3K) activity and the use of green fluorescent protein tagged derivatives of domains capable of specifically binding the lipid products of PI3Ks in vivo, it has been shown that this family of signalling enzymes have vital and distinct roles in chemotaxis, phagocytosis and phagosome maturation ...
Chris D. Ellson +2 more
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Assays of leukocyte locomotion and chemotaxis
Journal of Immunological Methods, 1998This review discusses the range of methods which are currently available for measuring locomotion and chemotaxis of leukocytes in vitro, their history, and some definitions of terms. Assays of the net migration of large cell populations, such as the filter assay are the most popular and are useful for identifying chemoattractant molecules, but give no ...
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[10] Measurement of leukocyte chemotaxis in vivo
1988Publisher Summary This chapter discusses the comparisons of the various methods and the air sac technique, which is used in the laboratory for studying early inflammatory responses to various chemotactic stimuli in mice. In examining these methods, a variety of considerations will be addressed: (l) simplicity and versatility of the method, (2 ...
Michael J. P. Lawman +3 more
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[14] Natural mediators of leukocyte chemotaxis
1988Publisher Summary This chapter discusses the natural mediators of leukocyte chemotaxis. Putative chemotactic factors must fulfill some, if not all, of the conditions. They should be present at the inflammation site to induce leukotaxis. The amount (or activity) of the chemotactic factors should be proportional to the extent of leukotaxis. They should
Mitsuo Honda +4 more
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Biologic Aspects of Leukocyte Chemotaxis [PDF]
, 1977 To protect a host against microbial invasion and the development of neoplasms, the immune system must discriminate self from nonself and then efficiently localize and eliminate material recognized as nonself. The process of localizing, degrading, and eliminating nonself can be termed an immune effector function and is largely mediated by the ...
Marilyn C. Pike, Ralph Snyderman
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Mechanisms of leukocyte motility and chemotaxis
Current Opinion in Immunology, 1994Motility is a complex process that depends on the coordination of many cellular functions, including the conversion of information from the environment into a series of coordinated responses that culminate in directed cell movement. Major advances have been made in the understanding of many functions involved in motility, such as transmembrane ...
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Methods for Quantitation of Leukocyte Chemotaxis and Fugetaxis
2010Chemoattraction and chemorepulsion are complex directional responses of a cell to external chemotactic stimuli. The decision of a cell to move towards or away from a chemokinetic source includes detection and quantitation of the gradient of the chemotactic agent, biochemical transmission of the stimulus, and translation into a directional migration ...
VIANELLO, FABRIZIO +2 more
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Cellular augmentation of polymorphonuclear leukocyte chemotaxis
American Journal of Physiology-Cell Physiology, 1979The density of neutrophils influences the number of cells that will respond to a chemoattractant, endotoxin-activated serium. When fewer than 3 x 10(5) polymorphonuclear leukocytes (PMN) were placed in the top compartment of a modified Boyden chemotaxis chamber, the cellular response was weak.
R. H. Persellin, A. Takeuchi
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A Role for the Laminin Receptor in Leukocyte Chemotaxis
Journal of Leukocyte Biology, 1987Abstract Previous studies on the mechanism of leukocyte traversal of basement membranes showed that rabbit peritoneal exudate polymorphonuclear cells (PMN) preferentially used laminin, a major constituent of basement membrane, to attach to another component, type IV collagen.
E. Schiffmann +7 more
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