Results 51 to 60 of about 99,840 (283)

Protein Palmitoylation in Leukocyte Signaling and Function

Frontiers in Cell and Developmental Biology, 2020
Palmitoylation is a post-translational modification (PTM) based on thioester-linkage between palmitic acid and the cysteine residue of a protein. This covalent attachment of palmitate is reversibly and dynamically regulated by two opposing sets of ...
Xiaoyuan Yang, Victor Chatterjee, Yonggang Ma, Ethan Zheng, Sarah Y. Yuan, Sarah Y. Yuan   +5 more
doaj   +1 more source

Effects of oxidized low density lipoprotein, lipid mediators and statins on vascular cell interactions [PDF]

, 1999
The integrin heterodimer CD11b/CD18 (alpha M beta 2, Mac-1, CR3) expressed on monocytes or polymorphonuclear leukocytes (PMN) is a receptor for iC3b, fibrinogen, heparin, and for intercellular adhesion molecule (ICAM)-1 on endothelium, crucially ...
Amatruda TT, Bednar MM, Bellosta S, Buttrum SM, Buyon JP, Calara F, Calderon TM, Diacovo TG, Giroux LM, Jukema JW, Kim JA, Kimura M, Laufs U, Laws KH, Lehr H-A, Marcus AJ, Notabartolo A, Olstrowsky L, Pons F, Ruf A, Smalley DM, Stragliotto E, Sugiyama S, Weber C, Weber C, Weber C, Yeagle PL, Yeo EL, Yue TL   +28 more
core   +1 more source

Progress and Prospects of Persistent Luminescent Nanocrystals in Biomedical Applications

Advanced Optical Materials, EarlyView.
This review summarizes recent progress in materials‐level control of persistent luminescence, including mechanistic understanding, wavelength/intensity tuning, and activation strategies, as well as emerging biomedical applications in imaging, biosensing, cell tracking, optogenetic stimulation, and biophotochemical activation.
Peng Pei, Luping Wang, Haitong Jing, Xian Qin, Jiong‐Wei Wang, Xiaogang Liu   +5 more
wiley   +1 more source

The 5-Phosphatase SHIP2 Promotes Neutrophil Chemotaxis and Recruitment

Frontiers in Immunology, 2021
Neutrophils, the most abundant circulating leukocytes in humans have key roles in host defense and in the inflammatory response. Agonist-activated phosphoinositide 3-kinases (PI3Ks) are important regulators of many facets of neutrophil biology.
Melina Michael, Barry McCormick, Karen E. Anderson, Utsa Karmakar, Matthieu Vermeren, Stéphane Schurmans, Augustin Amour, Sonja Vermeren   +7 more
doaj   +1 more source

⁹⁹ᵐTc SPECT imaging agent based on cFLFLFK for the detection of FPR1 in inflammation [PDF]

, 2015
Non-invasive imaging of the inflammatory process can provide a great deal of insight into a wide variety of diseases states, aiding diagnosis, evaluation and effective targeted treatment. During inflammation, blood borne leukocytes are recruited, through
Gavins, Felicity N.E., Holloway, Paul M., Long, Nicholas J., Luthra, Sajinder Kaur, Morrison Iveson, Veronique, Rivas, Charlotte, Stasiuk, Graeme J., Trigg, William   +7 more
core   +2 more sources

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration [PDF]

, 2017
Varicella zoster virus (VZV) is a highly prevalent human pathogen that establishes latency in neurons of the peripheral nervous system. Primary infection causes varicella whereas reactivation results in zoster, which is often followed by chronic pain in ...
Bauerfeind, R. (Rudolf), Binz, A. (Anne), Durán, V. (Verónica), González-Motos, V. (Víctor), Jonjic, S. (Stipan), Jürgens, C. (Carina), Kalinke, U. (Ulrich), Kaufer, B.B. (Benedikt B.), Krey, T. (Thomas), Kropp, K.A. (Kai A.), Larsen, O. (Olav), Lenac Rovis, T. (Tihana), Ouwendijk, W.J.D. (Werner), Proudfoot, A.E.I. (Amanda E. I.), Ritter, B. (Birgit), Rosenkilde, M.M. (Mette M.), Schulz, T.F. (Thomas F.), Sodeik, B. (Beate), Verjans, G.M.G.M. (George), Viejo-Borbolla, A. (Abel)   +19 more
core   +4 more sources

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Weaning markedly affects transcriptome profiles and Peyer’s patch formation in piglet ileum

Frontiers in Immunology, 2015
Transcriptome analyses were conducted on the ileal mucosa of 14-35 day-old piglets to investigate postnatal gut development during suckling and post-weaning. The transcriptome profiles of 14 day-old suckling piglets showed a considerably higher number of
Ryo eInoue, Ryo eInoue, Takamitsu eTsukahara, Takamitsu eTsukahara, Masako eNakatani, Mie eOkutani, Ryoichiro eNishibayashi, Shohei eOgawa, Tomoko eHarayama, Takayuki eNagino, Hironori eHatanaka, Kikuto eFukuta, Gustavo eRomero-Perez, Kazunari eUshida, Denise eKelly   +14 more
doaj   +1 more source

Differential and Temporal Immunomodulation of alpha4 Integrins on CD4+ Memory Cells by Bordetella pertussis and Bordetella parapertussis [PDF]

, 2012
Pertussis, caused by Bordetella pertussis (B. pertussis), is reemerging worldwide due to vaccine inefficacy. The hallmarks of infection are extreme lymphocytosis and delayed recovery, which are partially associated with pertussis toxin.
Ravindra, Dipti
core   +1 more source