Results 51 to 60 of about 71,798 (273)

Protein Palmitoylation in Leukocyte Signaling and Function

Frontiers in Cell and Developmental Biology, 2020
Palmitoylation is a post-translational modification (PTM) based on thioester-linkage between palmitic acid and the cysteine residue of a protein. This covalent attachment of palmitate is reversibly and dynamically regulated by two opposing sets of ...
Xiaoyuan Yang, Victor Chatterjee, Yonggang Ma, Ethan Zheng, Sarah Y. Yuan, Sarah Y. Yuan   +5 more
doaj   +1 more source

The 5-Phosphatase SHIP2 Promotes Neutrophil Chemotaxis and Recruitment

Frontiers in Immunology, 2021
Neutrophils, the most abundant circulating leukocytes in humans have key roles in host defense and in the inflammatory response. Agonist-activated phosphoinositide 3-kinases (PI3Ks) are important regulators of many facets of neutrophil biology.
Melina Michael, Barry McCormick, Karen E. Anderson, Utsa Karmakar, Matthieu Vermeren, Stéphane Schurmans, Augustin Amour, Sonja Vermeren   +7 more
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Weaning markedly affects transcriptome profiles and Peyer’s patch formation in piglet ileum

Frontiers in Immunology, 2015
Transcriptome analyses were conducted on the ileal mucosa of 14-35 day-old piglets to investigate postnatal gut development during suckling and post-weaning. The transcriptome profiles of 14 day-old suckling piglets showed a considerably higher number of
Ryo eInoue, Ryo eInoue, Takamitsu eTsukahara, Takamitsu eTsukahara, Masako eNakatani, Mie eOkutani, Ryoichiro eNishibayashi, Shohei eOgawa, Tomoko eHarayama, Takayuki eNagino, Hironori eHatanaka, Kikuto eFukuta, Gustavo eRomero-Perez, Kazunari eUshida, Denise eKelly   +14 more
doaj   +1 more source

Cytokine, Chemokine, and Neurofilament Light Chain Signatures in LGI1 Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the value of cytokine, chemokine, and neurofilament light chain (NfL) concentrations in predicting relapse risk, chronic epilepsy, and functional impairment in LGI1 autoimmune encephalitis (AE). Methods Cytokines/chemokines (IL‐1‐beta, IL‐2, IL‐4, IL‐5, IL‐6, IL‐8/CXCL8, IL‐10, IL‐12p70, IL‐13, IL‐17A, GM‐CSF, TNF ...
Albert Aboseif, Georgios Mangioris, Binxia Yang, Vanessa K. Pazdernik, Jeffrey W. Britton, Divyanshu Dubey, Eoin P. Flanagan, Sarosh R. Irani, Gregory S. Day, Charles L. Howe, A. Sebastian López‐Chiriboga, Andrew McKeon, John R. Mills, Yahel Segal, Michel Toledano, Ivana Vodopivec, Sean J. Pittock, Anastasia Zekeridou   +17 more
wiley   +1 more source

Pharmacological Inhibition of p38 Mitogen-Activated Protein Kinases Affects KC/CXCL1-Induced Intraluminal Crawling, Transendothelial Migration, and Chemotaxis of Neutrophils In Vivo

Mediators of Inflammation, 2013
p38 mitogen-activated protein kinase (MAPK) signalling is critical in the pathophysiology of a variety of inflammatory processes. Leukocyte recruitment to the site of inflammation is a multistep process governed by specific signalling cascades.
Najia Xu, Mokarram Hossain, Lixin Liu
doaj   +1 more source

Morus alba and active compound oxyresveratrol exert anti-inflammatory activity via inhibition of leukocyte migration involving MEK/ERK signaling [PDF]

, 2013
Background: Morus alba has long been used in traditional Chinese medicine to treat inflammatory diseases;however, the scientific basis for such usage and the mechanism of action are not well understood. This studyinvestigated the action of M.
Chun-Houh Chen, Clément Mettling, Den-Jen Wu, Evangeline C Amor, Francesca N Beltran, Ran-Juh Wang, Wen-Chin Yang, Yea-Lih Lin, Yi-Ching Chen, Yin-Jing Tien   +9 more
core   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour [PDF]

, 2011
The mechanism of eukaryotic chemotaxis remains unclear despite intensive study. The most frequently described mechanism acts through attractants causing actin polymerization, in turn leading to pseudopod formation and cell movement.
A Cvejic, A Millius, A Mogilner, A Narang, A. P Wheeler, B Varnum-Finney, C Arrieumerlou, C Janetopoulos, C. I Lacayo, C. P McCann, Douwe M. Veltman, G Dziuk, G Gerisch, H Levine, H Meinhardt, H. R Bourne, I. M Mitchell, J Satulovsky, J. A Swanson, John A. Mackenzie, K Keren, K. F Swaney, L Bosgraaf, L Bosgraaf, L Chen, L Li, L Ma, M Enculescu, M. A Lokuta, M. P Neilson, Matthew P. Neilson, N Andrew, O Brandman, O Hoeller, O. D Weiner, O. D Weiner, P Devreotes, P. A Iglesias, P. J Van Haastert, Peter J. M. van Haastert, R. H Insall, R. H Insall, R. H Insall, R. T Tranquillo, Robert H. Insall, S Osher, S Srinivasan, Steven D. Webb, T Inoue, T Killich, T Killich, Thomas Pollard, X Zheng   +52 more
core   +8 more sources