Results 141 to 150 of about 442,266 (316)
Modeling branching and chiral colonial patterning of lubricating bacteria
, 1998 In nature, microorganisms must often cope with hostile environmental conditions. To do so they have developed sophisticated cooperative behavior and intricate communication capabilities, such as: direct cell-cell physical interactions via extra-membrane ...
Ben-Jacob, Eshel +3 more
core +1 more source
Mapping the Tissue‐of‐Origins of Mesenchymal Stromal Cells in Injury Repair
Advanced Science, EarlyView.This study maps mesenchymal stromal cells (MSCs) across multiple tissues, revealing that bone marrow–derived MSCs mobilize monocytes via CCL2 to promote systemic inflammation but do not migrate to distant organs to form fibrotic or tumor stroma. Instead, local MSCs dominate tissue remodeling, suggesting a “two‐hit” model linking systemic inflammation ...
Xinyu Thomas Tang +4 more
wiley +1 more source
Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation
Advanced Science, EarlyView.Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li +18 more
wiley +1 more source
Dietary E. coli promotes age-dependent chemotaxis decline in C. elegans
Scientific ReportsAn animal’s ability to sense odors declines during aging, and its olfactory drive is tuned by internal states such as satiety. However, whether internal states modulate an age-dependent decline in odor sensation is unknown.
Nadia Suryawinata +6 more
doaj +1 more source
Advanced Science, EarlyView.Neoadjuvant gemcitabine plus nab‐paclitaxel (AG) reprograms pancreatic ductal adenocarcinoma by shifting malignant cells toward a classical phenotype and remodeling the tumor microenvironment. Despite enhancing cytotoxic NKT cells, AG activates tumor‐associated mast cells (TAMCs) and inflammatory CAFs through MIF signaling.
Libo Wang +16 more
wiley +1 more source
Two Novel S‐methyltransferases Confer Dimethylsulfide Production in Actinomycetota
Advanced Science, EarlyView.This study identifies two novel S‐adenosine‐methionine‐dependent methyltransferases, MddM1 and MddM2, in actinomycetes from the Mariana Trench. These enzymes can convert toxic hydrogen sulfide (H2S) and methanethiol (MeSH) into dimethylsulfide (DMS), serving as a cellular detoxification and oxidative stress response.
Ruihong Guo +11 more
wiley +1 more source
tlpA gene expression is required for arginine and bicarbonate chemotaxis in Helicobacter pylori
Biological Research, 2011 About half of the human population is infected with Helicobacter pylori, a bacterium causing gastritis, peptic ulcer and progression to gastric cancer. Chemotaxis and flagellar motility are required for colonization and persistence of H.
Oscar A Cerda +5 more
doaj
RasGEF-containing proteins GbpC and GbpD have differential effects on cell polarity and chemotaxis in Dictyostelium [PDF]
, 2005 Leonard Bosgraaf +6 more
openalex +1 more source
Advanced Science, EarlyView.This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao +13 more
wiley +1 more source
Advanced Science, EarlyView.This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing +10 more
wiley +1 more source