Results 41 to 50 of about 404,279 (303)

A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus: towards the development of novel anti-inflammatory compounds [PDF]

, 2010
Complement factor C5a is one of the most powerful pro-inflammatory agents involved in recruitment of leukocytes, activation of phagocytes and other inflammatory responses.
AJ Wright, Anton Bunschoten, B Postma, B Postma, BO Gerber, Carla J. C. de Haas, CE Stotz, DE Epps van, F Blanco, H Lee, J Cavanagh, JH Ippel, JJ Chen, Johan Kemmink, Johannes H. Ippel, John A. W. Kruijtzer, KE Veldkamp, LM Proctor, Louris Feitsma, M Allegretti, M Farzan, PJ Haas, PN Monk, RF Guo, Rob M. J. Liskamp, TS Haque, ZG Chen   +26 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Asymmetric random walks reveal that the chemotaxis network modulates flagellar rotational bias in Helicobacter pylori

eLife, 2021
The canonical chemotaxis network modulates the bias for a particular direction of rotation in the bacterial flagellar motor to help the cell migrate toward favorable chemical environments.
Jyot D Antani, Anita X Sumali, Tanmay P Lele, Pushkar P Lele   +3 more
doaj   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Global Existence and Asymptotic Behavior of Solutions to a Chemotaxis-Fluid System on General Bounded Domain [PDF]

, 2014
In this paper, we investigate an initial-boundary value problem for a chemotaxis-fluid system in a general bounded regular domain $\Omega \subset \mathbb{R}^N$ ($N\in\{2,3\}$), not necessarily being convex.
Jiang, Jie, Wu, Hao, Zheng, Songmu
core  

Fibrinogen Changes Before and After Intravenous Thrombolysis as Predictors of Cerebral Injury and Clinical Outcomes in Acute Ischemic Stroke: A Multicenter Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma fibrinogen is essential in thrombosis and fibrinolysis, yet its dynamic changes pre‐ and post‐intravenous thrombolysis (IVT) for predicting brain injury severity and prognosis in acute ischemic stroke (AIS) patients remain unclear.
Wenhai Zhai, Yang Qu, Reziya Abuduxukuer, Kejia Zhang, Peng Zhang, Xin Tang, Huaimei Zhang, Lijuan Wang, Lichong Yang, Shuangxu Tan, Zhimei Yuan, Ce Han, Lili He, Yuping Zheng, Fenglan Zhao, Lijie Guo, Ligang Jiang, Jinfeng Li, Yongfei Jiang, Xuexia Zou, Dan Xu, Han Xu, Xiaojia Wang, Yingbin Qi, Xuefeng Hu, Yu Zhang, Zhen‐Ni Guo, Hang Jin, on behalf of the Biomarkers of Brain Injury Investigator Study Group   +28 more
wiley   +1 more source

An Updated Perspective on Sinorhizobium meliloti Chemotaxis to Alfalfa Flavonoids

Frontiers in Microbiology, 2020
The symbiotic interaction between leguminous plants and their cognate rhizobia allows for the fixation of gaseous dinitrogen into bioavailable ammonia.
K. Karl Compton, Sherry B. Hildreth, Richard F. Helm, Birgit E. Scharf   +3 more
doaj   +1 more source

A novel computer vision‐based assessment of neutrophil chemotaxis in patients with severe infection

Clinical & Translational Immunology, 2021
Objectives To evaluate the value of chemotactic function of neutrophils in patients with severe infections. Methods A computer vision‐based cellular chemotaxis analysis platform was established for the dynamic assessment of neutrophil chemotaxis.
Yunxi Yang, Lu Liu, Zaiwen Guo, Jiamin Huang, Linbin Li, Yiming Shao, Mingming Song, Aixiang Yang, Bingwei Sun   +8 more
doaj   +1 more source

A Novel Microfluidic Device for the Neutrophil Functional Phenotype Analysis: Effects of Glucose and Its Derivatives AGEs

Micromachines, 2021
Neutrophil dysfunction is closely related to the pathophysiology of patients with diabetes mellitus, but existing immunoassays are difficult to implement in clinical applications, and neutrophil’s chemotaxis as a functional biomarker for diabetes ...
Ke Yang, Xiao Yang, Chaoru Gao, Changyi Hua, Chenggang Hong, Ling Zhu   +5 more
doaj   +1 more source

Nonlinear mean field Fokker-Planck equations. Application to the chemotaxis of biological populations

, 2008
We study a general class of nonlinear mean field Fokker-Planck equations in relation with an effective generalized thermodynamical formalism. We show that these equations describe several physical systems such as: chemotaxis of bacterial populations ...
Chavanis, Pierre-Henri
core   +4 more sources