Results 71 to 80 of about 386,482 (254)

Lupus serum induces inflammatory interaction with neutrophils in human glomerular endothelial cells

Lupus Science and Medicine, 2020
Objectives SLE is associated with endothelial cell dysfunction (ECD). Understanding how ECD leads to neutrophil infiltration into glomeruli is essential to finding therapeutic targets for SLE. The aim of this study is to determine the effect of SLE serum
Jim C Oates, Dayvia A Russell, Margaret Markiewicz   +2 more
doaj   +1 more source

Arresting Microphase Separation Encodes Material Mechanics by Sculpting Microarchitectures and Local Polymer Enrichment

Advanced Materials, EarlyView.
Microarchitecture sculpting via phase separation programs hydrogel mechanics by creating globular, inverse globular, and spinodal structures. Spinodal architectures deliver superior toughness and energy dissipation, while ionic modulation through single polymer phase separation offers a simple, scalable route to tune mechanical properties ...
Castro Johnbosco, Floris Dalenoord, Jarno Hiemstra, Yu Na, Alexis Wolfel, Cécile Bosmans, Christine Gering, Niels Willemen, Su Ryon Shin, Jeroen Leijten   +9 more
wiley   +1 more source

Tumor growth instability and the onset of invasion

, 2005
Motivated by experimental observations, we develop a mathematical model of chemotactically directed tumor growth. We present an analytical study of the model as well as a numerical one.
A. H. Nayfeh, A. J. Ekstrand, A. J. Ekstrand, A. Wells, A.-L. Barabási, Carmen Molina-París, D. S. Jones, H. M. Byrne, J. A. Sherratt, J. P. Freyer, J. P. Freyer, M. J. Holmes, M. R. Chicoine, M. R. Chicoine, Mario Castro, P. C. Fife, P. Grindrod, R. K. Jain, S. H. Strogatz, S. Koochekpour, Thomas S. Deisboeck   +20 more
core   +1 more source

High‐Throughput 3D Matrigel‐based Droplet Microfluidics for Single‐Cell Function‐to‐Omics Analysis of Cytotoxic Immune Cells in Solid Tumor Interactions

Advanced Materials Technologies, EarlyView.
A 3D Matrigel‐based droplet microfluidics platform that allows physiologically relevant analysis of single immune‐tumor interactions in solid tumors. By integrating real‐time functional imaging with fluorescence‐activated droplet sorting and RNA sequencing, the system links immune cytotoxic behavior to transcriptomic profiles, providing a scalable ...
Christina Sharkey, Harry Akligoh, Michael Finocchiaro, Abhishek Srihari Rampelli, Zongwei Wang, Aria F. Olumi, Tania Konry   +6 more
wiley   +1 more source

Pseudomonas aeruginosa Performs Chemotaxis to the Neurotransmitters Serotonin, Dopamine, Epinephrine and Norepinephrine

Microbial Biotechnology
Bacteria use chemotaxis to move to favourable ecological niches. For many pathogenic bacteria, chemotaxis is required for full virulence, particularly for the initiation of host colonisation. There do not appear to be limits to the type of compounds that
Elizabet Monteagudo‐Cascales, Andrea Lozano‐Montoya, Tino Krell   +2 more
doaj   +1 more source

Hydrogel Confinement Strategies for 3D Cell Culture in Microfluidic Systems

Advanced Materials Technologies, EarlyView.
Hydrogel confinement structures are key to organizing 3D cell cultures in microfluidic devices. This review classifies five structural strategies (micropillar, phaseguide, porous membrane, stepped‐height, and support‐free) and examines their trade‐offs alongside fabrication methods.
Soohyun Kim, Min Seok Lee, Sung Kyun Lee
wiley   +1 more source

COP5/HKR1 changes ciliary beat pattern and biases cell steering during chemotaxis in Chlamydomonas reinhardtii

Scientific Reports
This study investigates the control of ciliary beat patterns during ammonium chemotaxis in the model ciliate microalga Chlamydomonas reinhardtii. Screening the chemotaxis response of mutant strains with ciliary defects revealed that a strain lacking CAV2,
Alexis Strain, Nathan Kratzberg, Dan Vu, Emmaline Miller, Ken-ichi Wakabayashi, Adam Melvin, Naohiro Kato   +6 more
doaj   +1 more source

A real time chemotaxis assay unveils unique migratory profiles amongst different primary murine macrophages.

PLoS ONE, 2013
Chemotaxis assays are an invaluable tool for studying the biological activity of inflammatory mediators such as CC chemokines, which have been implicated in a wide range of chronic inflammatory diseases.
Asif J Iqbal, Daniel Regan-Komito, Ivy Christou, Gemma E White, Eileen McNeill, Amy Kenyon, Lewis Taylor, Theodore S Kapellos, Edward A Fisher, Keith M Channon, David R Greaves   +10 more
doaj   +1 more source

Two‐Photon Polymerized Microvascular Environments for Multicellular Modeling of the Blood–Brain Tumor Barrier

Advanced Materials Technologies, EarlyView.
Modeling the blood–brain tumor barrier is challenging due to complex interactions between brain microvasculature and glioma cells. We present two‐photon polymerized 3D micro‐porous capillary‐like structures that support endothelial alignment, cytoskeletal organization, and pericyte‐endothelial‐glioma tri‐cultures.
Nastaran Barin, Sayba Z. Chowdhury, Maurice de Wit, Rania Head, Kiki Bals, Erwin Brosens, Marvin M. van Luijn, Hayri E. Balcioglu, Angelo Accardo, Pim J. French   +9 more
wiley   +1 more source

Novel Pseudotaxis Mechanisms Improve Migration of Straight-Swimming Bacterial Mutants Through a Porous Environment

mBio, 2015
Bacterial locomotion driven by flagella is given directionality by the chemotaxis signal transduction network. In the classic plate assays of migration in porous motility agar, efficient motility is compromised in chemotaxis mutants of diverse bacteria ...
Bitan Mohari, Nicholas A. Licata, David T. Kysela, Peter M. Merritt, Suchetana Mukhopadhay, Yves V. Brun, Sima Setayeshgar, Clay Fuqua   +7 more
doaj   +1 more source