Results 31 to 40 of about 16,871 (260)

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

ChemMedChem, EarlyView.
Several derivatives incorporating five‐membered aromatic rings are described in this review as bile acid receptor modulators, particularly targeting the farnesoid X receptor and the G protein‐coupled bile acid receptor 1. This review provides a comprehensive analysis of patents and literature that is useful to support researchers in the design of new ...
Claudia Finamore, Carmen Festa, Rosa Barbato, Stefano Fiorucci, Angela Zampella, Simona De Marino   +5 more
wiley   +1 more source

Effect of phospholipids and bile acids on cholesterol nucleation time and vesicular/micellar cholesterol in gallbladder bile of patients with cholesterol stones [PDF]

, 1993
Supersaturation and rapid nucleation of cholesterol in bile are of key importance in the pathogenesis of cholesterol gallstones. While the effects of bile acids and phospholipids on cholesterol saturation of bile have been extensively studied, their ...
Huber, P., Jüngst, Dieter, Lang, Thomas, Lange, V., Paumgartner, Gustav   +4 more
core  

The FXR agonist obeticholic acid inhibits the cancerogenic potential of human cholangiocarcinoma [PDF]

, 2019
Cholangiocarcinoma (CCA) is an aggressive cancer with high resistance to chemotherapeutics. CCA is enriched in cancer stem cells, which correlate with aggressiveness and prognosis.
Adorini, L., Alvaro, D., Berloco, P. B., Bragazzi, M., Cardinale, V., Carpino, G., Costantini, D., De Rose, A. M., Di Matteo, S., Gaudio, E., Giorgi, A., Giuliante, F., Giulitti, F., Grazi, G., Manzi, E., Melandro, F., Napoletano, C., Nevi, L., Overi, D., Safarikia, S.   +19 more
core   +3 more sources

Challenges and Opportunities in the Use of Iron Photosensitizers for Dye‐Sensitized Solar Cells and Photoelectrosynthetic Cells Applications

EcoEnergy, EarlyView.
This review gathers examples of iron‐based photosensitizers that have been successfully immobilized on metal oxide surfaces for dye‐sensitized solar cells and potential dye‐sensitized photoelectrosynthesic cells applications. A critical comparison of Fe‐based photosensitizers is made based on their photophysical properties, electrochemistry, and ...
Lakshmi Narayan Satheesh, Katerina Achilleos, Abdullah M. Abudayyeh, Ludovic Troian‐Gautier   +3 more
wiley   +1 more source

Proteome profiling by label‐free mass spectrometry reveals differentiated response of Campylobacter jejuni 81–176 to sublethal concentrations of bile acids.

, 2019
Purpose Bile acids are crucial components of the intestinal antimicrobial defense and represent a significant stress factor for enteric pathogens. Adaptation processes of Campylobacter jejuni to this hostile environment are analyzed in this study by a ...
Bohne, W., Dakna, M., Gross, U., Leha, A., Lenz, C., Lugert, R., Masanta, W., Zautner, A.   +7 more
core   +1 more source

The plasma level of 7α-hydroxy-4-cholesten-3-one reflects the activity of hepatic cholesterol 7α-hydroxylase in man [PDF]

, 1991
Circulating levels of 7α-hydroxy-4-cholesten-3-one have been compared with activities of the rate-limiting enzyme in bile acid synthesis, microsomal cholesterol 7α-hydroxylase, measured in liver biopsies obtained from patients undergoing surgery for ...
Axelson, Magnus, Björkhem, Ingemar, Einarsson, Kurt, Reihnér, Eva   +3 more
core   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload [PDF]

, 2011
Iron overload is the hallmark of hereditary hemochromatosis and a complication of iron-loading anemias such as β-thalassemia. Treatment can be burdensome and have significant side effects, and new therapeutic options are needed.
Alan Waring, Bo Qiao, Elizabeta Nemeth, Emilio Ramos, Fujita, Gloria C. Preza, Gualdi, Kearney, Lyskov, Michael A. Peralta, Nemeth, Piotr Ruchala, Porter, Rogelio Pinon, Sham, Shantanu Sharma, Tomas Ganz   +16 more
core   +2 more sources

Formation of ursodeoxycholic acid from chenodeoxycholic acid in the human colon: studies of the role of 7-ketolithocholic acid as an intermediate.

Journal of Lipid Research, 1983
The formation of ursodeoxycholic acid from chenodeoxycholic acid and the role of 7-ketolithocholic acid as an intermediate in this biotransformation were studied in vitro in fecal incubations as well as in vivo in the human colon.
H Fromm, R P Sarva, F Bazzoli
doaj  

A gut microbiota‐bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N

iMeta, EarlyView.
Bacteroides fragilis employs bile salt hydrolase to reprogram host bile acid metabolism, generating lithocholic acid that directly blocks porcine deltacoronavirus infection by disrupting spike protein‐aminopeptidase N binding, defining a microbiota‐bile acid antiviral axis with therapeutic potential against coronaviruses.
Ya‐Qing Zhang, Bin Wang, Yong‐Le Yang, Jin‐Xin Meng, Meng‐Di Zhang, Yi‐Ke Li, Bo Dong, Yanan Zhang, Bo‐Wen Liu, Dong Yang, Chun‐Miao Ji, Yao‐Wei Huang, Shu Jeffrey Zhu   +12 more
wiley   +1 more source