Results 41 to 50 of about 5,134,427 (306)

pH-Solubility relations of chenodeoxycholic and ursodeoxycholic acids: physical-chemical basis for dissimilar solution and membrane phenomena.

Journal of Lipid Research, 1980
We examined by titration the electrochemical properties, apparent pK (pK'a), precipitation pH, and undissociated bile acid solubilities of chenodeoxycholic acid and its 7 beta epimer, ursodeoxycholic acid and their glycine conjugates as functions of a ...
H Igimi, M C Carey
doaj   +1 more source

Evaluation of the effect of chenodeoxycholic acid treatment on skeletal system findings in patients with cerebrotendinous xanthomatosis

Türk pediatri arşivi, 2019
Aim: The primary purpose of the present study is to evaluate the effect of chenodeoxycholic acid treatment on skeletal system findings in patients with cerebrotendinous xanthomatosis.
Tanyel Zübarioğlu, İnci Pınar Bilen, E. Kıykım, B. Doğan, E. Enver, M. Cansever, A. A. Zeybek   +6 more
semanticscholar   +1 more source

The economy of the enterohepatic circulation of bile acids in the baboon. 2. Regulation of bile acid synthesis by enterohepatic circulation of bile acids.

Journal of Lipid Research, 1984
Isotope dilution within bile acid pools and radiochemical assessment of cholesterol oxidation to bile acids were methods used to measure short-term feedback regulation of bile acid synthesis in baboons with controlled enterohepatic circulations ...
R N Redinger
doaj   +1 more source

BaiJ and BaiB are key enzymes in the chenodeoxycholic acid 7α-dehydroxylation pathway in the gut microbe Clostridium scindens ATCC 35704

Gut microbes
Bile acid transformation is a common gut microbiome activity that produces secondary bile acids, some of which are important for human health. One such process, 7α-dehydroxylation, converts the primary bile acids, cholic acid and chenodeoxycholic acid ...
Karin Lederballe Meibom, Solenne Marion, Colin Volet, Théo Nass, Eduard Vico-Oton, Laure Menin, R. Bernier-Latmani   +6 more
semanticscholar   +1 more source

Bile acid formation in man: metabolism of 7α-hydroxy-4-cholesten-3-one in bile fistula patients

Journal of Lipid Research, 1973
7α-Hydroxy-4-cholesten-3-one is thought to be an intermediate in human bile acid synthesis. This conclusion is based on in vivo experiments in animals and on in vitro studies in which homogenates of animal and human livers were used. To further establish
Russell F. Hanson, Peter D. Klein, Gale C. Williams   +2 more
doaj   +1 more source

Evaluating hepatobiliary transport with 18F-labeled bile acids : the effect of radiolabel position and bile acid structure on radiosynthesis and in vitro and in vivo performance [PDF]

, 2018
Introduction. An in vivo determination of bile acid hepatobiliary transport efficiency can be of use in liver disease and preclinical drug development.
De Lombaerde, Stef, De Vos, Filip, Kersemans, Ken, Neyt, Sara, Vanhove, Christian, Verhoeven, Jeroen   +5 more
core   +3 more sources

Bile acid synthesis in HepG2 cells: effect of cyclosporin

Journal of Lipid Research, 1994
The hypothesis that cyclosporin specifically affects the pathway of bile acid synthesis that begins with 27-hydroxylation of cholesterol was evaluated in HepG2 cells, which synthesize chenodeoxycholic acid and cholic acid from endogenous 7 alpha ...
J Levy, K Budai, N B Javitt
doaj   +1 more source

Quantification of the 15 major human bile acids and their precursor 7α-hydroxy-4-cholesten-3-one in serum by liquid chromatography-tandem mass spectrometry [PDF]

, 2010
Bile acids are increasingly gaining attention since they were discovered to be activators of the transcription factor farnesoid X receptor (FXR) in addition to their well-established role in dietary lipid emulsification.
Alnouti, Ando, Arnold von Eckardstein, Bentayeb, Bjorkhem, Burkard, Camilleri, Carine Steiner, Cariou, Caron, Claudel, DeBarber, Duran-Sandoval, Honda, Karuna, Katharina M. Rentsch, Kuipers, Lefebvre, Lovgren-Sandblom, Makishima, Parks, Sauter, Scherer, Staels, Tagliacozzi, Tessier, Wang, Xiang, Ye, Zhang   +29 more
core   +1 more source

Human hepatoblastoma cells (HepG2) and rat hepatoma cells are defective in important enzyme activities in the oxidation of the C27 steroid side chain in bile acid formation

Journal of Lipid Research, 1993
We have examined the ability of HepG2 human hepatoblastoma cells and 7800 C1 Morris rat hepatoma cells to convert 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid (THCA) and 3 alpha, 7 alpha-dihydroxy-5 beta-cholestanoic acid (DHCA) to ...
Ann-Kristin Östlund Farrants, Astrid Nilsson, Jan I. Pedersen   +2 more
doaj   +1 more source

Obeticholic acid for the treatment of primary biliary cholangitis in adult patients: clinical utility and patient selection. [PDF]

, 2016
Primary biliary cholangitis (PBC), previously known as primary biliary "cirrhosis", is a rare autoimmune liver disease characterized by the hallmark autoantibodies to mitochondrial antigens and immune-mediated destruction of small bile duct epithelial ...
Bowlus, Christopher L
core   +3 more sources