Results 61 to 70 of about 5,134,427 (306)

Chenodeoxycholic acid normalizes elevated lipoprotein secretion and catabolism in cerebrotendinous xanthomatosis.

Journal of Lipid Research, 1989
Cerebrotendinous xanthomatosis (CTX) is a rare inherited lipid storage disease caused by a defect in bile acid synthesis in which cholesterol and its product cholestanol are deposited in neurological and vascular tissue.
G S Tint, H Ginsberg, G Salen, N A Le, S Shefer   +4 more
doaj   +1 more source

Bile Acids Conjugation in Human Bile Is Not Random: New Insights from 1H-NMR Spectroscopy at 800 MHz [PDF]

, 2009
Bile acids constitute a group of structurally closely related molecules and represent the most abundant constituents of human bile. Investigations of bile acids have garnered increased interest owing to their recently discovered additional biological ...
Cooper, Amanda, Maluccio, Mary, Nagana Gowda, G. A., Raftery, Daniel, Shanaiah, Narasimhamurthy   +4 more
core   +1 more source

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

Animal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao, Jie Liu, Rui Yang, Xizhen Fan, Cheng Liang, Xin'e Shi, Jianjun Jin   +6 more
wiley   +1 more source

Circular dichroism spectroscopic detection of ligand binding induced subdomain IB specific structural adjustment of human serum albumin [PDF]

, 2013
This work demonstrates for the first time that binding of various compounds within subdomain IB of human serum albumin (HSA) provokes characteristic changes in the near-UV circular dichroism (CD) spectrum of the protein.
Beaven G. H., Bertucci C., Bertucci C., Bhattacharya A. A., Brock A., Buttar D., Carter D. C., Curry S., Curry S., Datta P., Dockal M., Farruggia B., Fehske K. J., Fehske K. J., Fehske K. J., Ferenc Zsila, Ghuman J., Ishida S., Koide M., Kragh-Hansen U., Krenzel E. S., Plager J. E., Ryan A. J., Ryan A. J., Sengupta A., Shi D., Simard J. R., Sjöholm I., Strickland E. H., Sudlow G., Sudlow G., Takikawa H., Wanwimolruk S., Zhu L., Zsila F., Zsila F., Zunszain P. A., Zunszain P. A.   +37 more
core   +1 more source

Metabolism and choleretic activity of homochenodeoxycholic acid in the hamster

Journal of Lipid Research, 1993
The hepatic metabolism and the choleretic effect of homochenodeoxycholic acid, the C25 homologue of chenodeoxycholic acid, were investigated in the hamster.
S Miki, BI Cohen, T Mikami, EH Mosbach
doaj   +1 more source

Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis

OncoTarget, 2016
Accumulation of hydrophobic bile acids in the liver contributes to cholestatic liver injury. Inflammation induced by excessive bile acids is believed to play a crucial role, however, the mechanisms of bile acids triggered inflammatory response remain ...
Zizhen Gong, Jiefei Zhou, Shengnan Zhao, Chunyan Tian, Panliang Wang, Congfeng Xu, Yingwei Chen, W. Cai, Jin Wu   +8 more
semanticscholar   +1 more source

Nano‐plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction

iMeta, EarlyView.
The pervasiveness of microplastic pollution poses a growing health risk, yet its long‐term metabolic consequences remain poorly defined. Here, we exposed mice to polyethylene terephthalate nanoparticle (NP) and combined histopathology, biochemistry, metabolomics, and metagenomics to resolve their interactions.
Yi Zhang, Zheng Lin, Runtong Huang, Yang Zhang, Lei Wang, Zan Fu, Chao Wang, Shuai Xiao, Heru Pramono, Kui Xu, Zhimin Xu, Yulong Yin   +11 more
wiley   +1 more source

Reverse cross-coupling in the synthesis 3 alpha, 7 alpha-dihydroxy-5 beta-cholestanoic acid.

Journal of Lipid Research, 1979
The present report describes the characterization of (24R and 24S)-27-nor-24-methyl-3 alpha, 7 alpha-dihydroxy-5 beta-cholestan-26-oic acids obtained in considerable amounts during the synthesis of (25RS)-3 alpha, 7 alpha-dihydroxy-5 beta-cholestan-26 ...
K Kihira, A K Batta, E H Mosbach, G Salen   +3 more
doaj   +1 more source

Downregulation of host tryptophan-aspartate containing coat (TACO) gene restricts the entry and survival of Leishmania donovani in human macrophage model [PDF]

, 2015
Leishmania are obligate intracellular protozoan parasites of mammalian hosts. Promastigotes of Leishmania are internalized by macrophages and transformed into amastigotes in phagosomes, and replicate in phagolysosomes.
Deepak eKaul, Mohan Lal Dubey, Rakesh eSehgal, Venkata Subba Rao Atluri, Venkateswara Reddy Gogulamudi, Venkateswara Reddy Gogulamudi   +5 more
core   +2 more sources

Circulating Profiles of the Bile Acid Metabolomics in Patients With Polycystic Ovary Syndrome Treated With Metformin or Canagliflozin

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
ABSTRACT Objective Bile acids are indispensable modulators in the development of polycystic ovary syndrome (PCOS). Our previous study identified that metformin and canagliflozin have similar efficacy in patients with PCOS combined with insulin resistance (IR).
Qi Yan, Meili Cai, Nan Wang, Wenhao Wu, Hua Zhang, Yikun Zhu, Jing Luo, Manna Zhang, Jin Li   +8 more
wiley   +1 more source