Results 81 to 90 of about 20,810 (232)

Relationship Between Fecal Bile Acid Profile and Intestinal Microbiota in Patients With Chronic Radiation Enteritis

Journal of Digestive Diseases, EarlyView.
Patients with chronic radiation enteritis (CRE) demonstrate dysregulated bile acid (BA) metabolism, characterized by an increased proportion of primary BAs and a decreased proportion of secondary BAs. Moreover, the diversity of the intestinal microbiota is significantly reduced in individuals with CRE, and there is a bidirectional interaction between ...
Xin Shen, Song Bo Li, Meng Jie Gao, Jiao Jiao Cao, Hua Yang, Wei Wei Li, Li Chun Wei, Min Chen, Jun Ye Liu, Yong Quan Shi   +9 more
wiley   +1 more source

Identification of (24E)-3 alpha,7 alpha-dihydroxy-5 beta-cholest-24-enoic acid and (24R,25S)-3 alpha,7 alpha,24-trihydroxy-5 beta-cholestanoic acid as intermediates in the conversion of 3 alpha,7 alpha-dihydroxy-5 beta-cholestanoic acid to chenodeoxycholic acid in rat liver homogenates.

Journal of Lipid Research, 1994
Studies of chemical structure of the intermediates in the biosynthetic sequence between 3 alpha,7 alpha-dihydroxy-5 beta-cholestanoic acid (DHCA) and chenodeoxycholic acid have been undertaken. Radiolabeled DHCA was incubated with a rat liver preparation.
M. Une, A. Inoue, T. Kurosawa, M. Tohma, T. Hoshita   +4 more
doaj   +1 more source

Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration. [PDF]

, 2015
Background & aimsAll-trans Retinoic acid (RA) regulates hepatic lipid and bile acid homeostasis. Similar to bile acid (BA), RA accelerates partial hepatectomy (PHx)-induced liver regeneration.
Hu, Ying, Liu, Hui-Xin, Wan, Yu-Jui Yvonne   +2 more
core   +2 more sources

High cholesterol absorption efficiency interferes with bile acid metabolism and cholesterol elimination from the body

Journal of Internal Medicine, EarlyView.
Abstract Background Elevated low‐density lipoprotein (LDL) cholesterol causes atherosclerotic cardiovascular diseases. Variables of whole‐body cholesterol metabolism, for example, high cholesterol absorption efficiency, might also be atherogenic, whereas the role of bile acids is controversial.
Piia Simonen, Ingmar Wester, Jyri Lommi, Juha Sinisalo, Helena Gylling   +4 more
wiley   +1 more source

The ionization behavior of bile acids in different aqueous environments.

Journal of Lipid Research, 1987
The ionization behavior of cholic acid, deoxycholic acid, and chenodeoxycholic acid in a variety of physiologically important molecular environments was studied using 13C NMR spectroscopy.
D J Cabral, J A Hamilton, D M Small
doaj   +1 more source

Variants in AKR1D1 and Infant Mortality: Should Bile Acid Screening be a Routine Part of Newborn Screening?

American Journal of Medical Genetics Part A, Volume 200, Issue 4, Page 971-977, April 2026.
ABSTRACT Biallelic pathogenic variants in AKR1D1 cause Δ4‐3‐oxosteroid 5β‐reductase deficiency, disrupt bile acid synthesis, and result in Congenital Bile Acid Synthesis defect type 2 (CBAS2). CBAS2 presents in infancy with cholestasis, coagulopathy, and failure to thrive.
Jade Hudson, Stephanie Hyunh, Bojana Rakic, Cornelius Boerkoel   +3 more
wiley   +1 more source

Biliary bile acids of fruit pigeons and doves (Columbiformes): presence of 1-beta-hydroxychenodeoxycholic acid and conjugation with glycine as well as taurine.

Journal of Lipid Research, 1994
The biliary bile acid composition of 30 species of pigeons and doves belonging to seven genera in the avian order Columbiformes was determined using TLC, HPLC, GLC/MS, LSIMS, and NMR.
L.R Hagey, C.D Schteingart, H T Ton-Nu, A.F Hofmann   +3 more
doaj   +1 more source

Gut Microbiome Dysbiosis Promotes Gallstone Formation via Bile Acid Metabolic Disorder: A Multiomics Study

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Gallstone patients exhibit intestinal dysbiosis, which leads to bile acid dysregulation. Gallstone patients exhibited increased levels of bacteria with bile salt hydrolase (BSH) activity. In gallstone patients, the levels of hydrophobic bile acids (e.g., lithocholic acid) were increased, while the levels of hydrophilic bile acids (e.g ...
Chongfei Huang, Weijun Xiao, Jinyu Zhao, Ruyang Zhong, Long Gao, Haidong Ma, Liang Tian, Ping Yue, Yanyan Lin, Qiangsheng He, Bin Xia, Jinqiu Yuan, Man Yang, Wenbo Meng   +13 more
wiley   +1 more source

27-Hydroxycholesterol: production rates in normal human subjects

Journal of Lipid Research, 1999
We attempted to quantitate production of bile acid via the 27-hydroxylation pathway in six human subjects. After bolus intravenous injection of known amounts of [24-14C]cholic acid and [24-14C]chenodeoxycholic acid, each subject underwent a constant ...
William C. Duane, Norman B. Javitt
doaj   +1 more source

TGR 5 signalling inhibits the production of pro‐inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease [PDF]

, 2013
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97471/1/imm12045 ...
Hibi, Toshifumi, Hisamatsu, Tadakazu, Ichikawa, Riko, Kamada, Nobuhiko, Kanai, Takanori, Kitazume, Mina T., Koganei, Kazutaka, Matsuoka, Katsuyoshi, Mori, Maiko, Namikawa, Yuka, Sato, Toshiro, Shimamura, Katsuyoshi, Sugita, Akira, Uo, Michihide, Yoneno, Kazuaki   +14 more
core   +1 more source