Results 81 to 90 of about 20,520 (283)

Discovery Of Copper Catalyst For New Chemical Polishing Acid On Superconducting Niobium [PDF]

arXiv, 2020
High field Q-slope (HFQS) seriously limits the high gradient performance of the buffered chemically polished (BCP) superconducting radio frequency (SRF) niobium cavities. The direct cause or mechanism is not yet fully understood. In our recent extensive data analysis, we concluded that the potential root cause could be nitrogen contamination on the ...
arxiv  

A thermodynamic basis for prebiotic amino acid synthesis and the nature of the first genetic code [PDF]

, 2009
Of the twenty amino acids used in proteins, ten were formed in Miller's atmospheric discharge experiments. The two other major proposed sources of prebiotic amino acid synthesis include formation in hydrothermal vents and delivery to Earth via meteorites.
arxiv   +1 more source

Hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and biliary lipid composition in man: relation to cholesterol gallstone disease and effects of cholic acid and chenodeoxycholic acid treatment

Journal of Lipid Research, 1981
The present work was undertaken in order to study whether or not there is a relation between hepatic HMG CoA reductase, hepatic cholesterol concentration, and biliary lipid composition.
J Ahlberg, B Angelin, K Einarsson
doaj  

The mood stabilizers lithium and valproate disrupt hepatic and intestinal farnesoid X receptor signalling and increase bile synthesis in the rat

Experimental Physiology, EarlyView.
Abstract The mood stabilizers lithium and valproate are psychotropic medications widely used in clinical practice. Despite their proven benefits, many individuals stop their treatment due to the adverse effects. Chronic diarrhoea is a common reason for discontinuation of these drugs; however, the underlying mechanisms are unknown.
Sofia Cussotto, Anna V. Golubeva, Alvaro Lopez Gallardo, Thomaz F. S. Bastiaanssen, Alexander V. Zhdanov, Gerard M. Moloney, Caitriona Scaife, Jane A. English, Susan A. Joyce, Timothy G. Dinan, John F. Cryan   +10 more
wiley   +1 more source

Synthesis of 11, 12-2H2- and 11, 12-3H2-labeled chenodeoxycholic and lithocholic acids

Journal of Lipid Research, 1976
Deuterium- and tritium-labeled chenodeoxycholic acid and lithocholic were prepared by catalytic reduction of their respective Δ11 derivatives. Structures of the intermediates and their isotopic purity were verified by chemical ionization and electron ...
A E Cowen, A F Hofmann, D L Hachey, P J Thomas, D T Belobaba, P D Klein, L Tökes   +6 more
doaj  

Farnesoid X Receptor and its ligands inhibit the function of platelets [PDF]

, 2016
Objective - While initially seemingly paradoxical due to the lack of nucleus, platelets possess a number of transcription factors that regulate their function through DNA-independent mechanisms.
Ali, Marfoua S., Bishop-Bailey, David, Bye, Alex P., Dombrowicz, David, Dorchies, Emilie, Flora, Gagan D., Gibbins, Jonathan M., Kriek, Neline, Molendi-Coste, Olivier, Moraes, Leonardo A., Sage, Tanya, Sasikumar, Parvathy, Staels, Bart, Unsworth, Amanda J., Vaiyapuri, Sakthivel   +14 more
core   +2 more sources

Identification of Soy‐Derived Peptides With Micelle Disruption Activity of Secondary Bile Acids

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
DCA‐binding peptides were identified in a peptide library from eight soy proteins. Of the 42 DCA‐binding peptides, 41 exhibited significant degradation of DCA micelles. Peptides capable of specifically disrupting DCA micelles were present in soy pepsin hydrolysates. ABSTRACT Bile acids, which originate in the liver as primary bile acids, facilitate the
Shota Shimizu, Keita Hirano, Tsutomu Saito, Hirokazu Akiyama, Kazunori Shimizu, Hiroyuki Honda   +5 more
wiley   +1 more source

Egy ritka, veleszületett neurodegeneratív betegség: a cerebrotendinosus xanthomatosis laboratóriumi diagnosztikája [PDF]

, 2014
Cerebrotendinous xanthomatosis is a rare neurodegenerative disease characterized by the accumulation of cholesterol and cholestanol in the brain and the tendons caused by mutations of the gene encoding sterol 27-hydroxylase (CYP27A1), which is involved ...
Balogh István, Harangi János, Harangi Mariann, Kapás István, Katkó Mónika, Kovács G. Gábor, Madar László, Molnár Mária Judit, Paragh György, Seres Ildikó, Varga Viktória Evelin   +10 more
core   +1 more source

Serum metabolic and microbial profiling yields insights into promoting effect of tryptophan‐related metabolites for health longevity in centenarians

iMeta, Volume 4, Issue 3, June 2025.
Schematic representation of the design. Tryptophan metabolism is enriched in serum metabolites and gut microbiota of centenarians, potentially contributing to healthy longevity. A key tryptophan metabolite 5‐methoxyindoleacetic acid (5‐MIAA) is linked to the Christensenellaceae R‐7 group and exhibits effects of delaying cell senescence, promoting ...
Xiaorou Qiu, Chao Mu, Jie Hu, Jiaxin Yu, Wenbo Tang, Yueli Liu, Yongmei Huang, Yixian Lu, Peihua Tang, Jingzhen Wu, Zixuan Huang, Xianlin Mei, Huaguo Xiang, Hao Lin, Yi Qi, Hui Luo, Xuemeng Li   +16 more
wiley   +1 more source

LC/ESI-MS analysis of underivatized amino acids and mass spectrum [PDF]

arXiv, 2016
We report the method of LC/ESI-MS analysis of underivatized amino acids with corresponding mass spectrum and fragmentation patterns. Diagnostic product ions determined by mass spectrometry can support the qualitative identification and quantitative estimation of individual amino acids. Therefore, the optimization of chromatographic separation using the
arxiv