Regulation of autophagy in chick myotube cultures: Effect of uncoupling mitochondrial oxidative phosphorylation [PDF]
The Journal of Poultry Science, 2023 s: Skeletal muscles have a high demand for ATP, which is met largely through mitochondria oxidative phosphorylation. Autophagy is essential for the maintenance of skeletal muscle mass under catabolic conditions.
Kazuki Nakashima, Aiko Ishida
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Regulation of Autophagy in Chick Myotubes: Effects of Insulin, Insulin-Like Growth Factor-I, and Amino Acids [PDF]
The Journal of Poultry Science, 2018 Autophagy, an intracellular bulk protein degradation system in skeletal muscle, is increased under catabolic conditions resulting in muscle atrophy. This study aimed to investigate the effects of insulin, insulin-like growth factor (IGF)-I, and amino ...
Kazuki Nakashima, Aiko Ishida
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The Wnt/Beta-Catenin Pathway and Cytoskeletal Filaments Are Involved in the Positioning, Size, and Function of Lysosomes during Chick Myogenesis [PDF]
Cells, 2022 Lysosomes are highly dynamic organelles involved in the breakdown and recycling of macromolecules, cell cycle, cell differentiation, and cell death, among many other functions in eukaryotic cells. Recently, lysosomes have been identified as cellular hubs
Kayo Moreira Bagri +4 more
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The ensured proliferative capacity of myoblast in serum-reduced conditions with Methyl-β-cyclodextrin [PDF]
Frontiers in Cell and Developmental Biology, 2023 To produce muscle fibers for cultured meat on a large scale, it is important to expand myoblasts in a serum-reduced or serum-free medium to avoid cost, ethical, and environmental issues.
Tomoka Katayama +2 more
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Chick embryo extract-driven culture system enhances chicken muscle satellite cell differentiation and 3D myotube formation [PDF]
npj Science of FoodThe rapid increase in global meat demand has placed significant pressure on traditional meat production. This has led to the emergence of the cultured meat industry as a promising alternative offering sustainable and ethical solutions.
Yookyung Kang +3 more
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Insulin Stimulation of Protein Synthesis and mTOR Signaling in Chick Myotube Cultures
The Journal of Poultry Science, 2020 Insulin stimulates protein synthesis in skeletal muscles. Protein synthesis is controlled by the mechanistic target of rapamycin (mTOR) signaling in skeletal muscles.
Kazuki Nakashima +4 more
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Microbiota-derived 3-phenylpropionic acid promotes myotube hypertrophy by Foxo3/NAD+ signaling pathway [PDF]
Cell & BioscienceBackground Gut microbiota and their metabolites play a regulatory role in skeletal muscle growth and development, which be known as gut-muscle axis. 3-phenylpropionic acid (3-PPA), a metabolite produced by colonic microorganisms from phenylalanine in the
Penglin Li +13 more
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Myostatin Increases Smad2 Phosphorylation and Atrogin-1 Expression in Chick Embryonic Myotubes
The Journal of Poultry Science, 2019 Skeletal muscle mass is an important trait in poultry meat production. In mammals, myostatin, a negative regulator of skeletal muscle growth, activates Smad transcription factors and induces the expression of atrogin-1 by regulating the Akt/FOXO pathway.
Takaoki Saneyasu +2 more
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Cold-Induced Suppression of Myogenesis in Skeletal Muscle Stem Cells Contributes to Delayed Muscle Regeneration During Hibernation. [PDF]
FASEB JHibernating mammals preserve satellite cell viability during extreme cold exposure by suppressing ferroptosis through elevated GPX4 expression. Although these cells survive cold stress, myogenic activation and differentiation are markedly reduced, leading to delayed muscle regeneration in vivo.
Miyaji T +12 more
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An atlas of caspase cleavage events in differentiating muscle cells. [PDF]
Protein SciAbstract Executioner caspases, such as caspase‐3, are known to induce apoptosis, but in other contexts, they can control very different fates, including cell differentiation and neuronal plasticity. While hundreds of caspase substrates are known to be specifically targeted during cell death, we know very little about how caspase activity brings about ...
Gomez-Cardona E +5 more
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