Results 31 to 40 of about 19,855 (219)

Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate

Scientific Reports, 2022
Chikungunya virus (CHIKV) is the causative agent of Chikungunya fever, an acute febrile and arthritogenic illness with no effective treatments available. The development of effective therapeutic strategies could be significantly accelerated with detailed
Marjorie C. L. C. Freire, Luis G. M. Basso, Luis F. S. Mendes, Nathalya C. M. R. Mesquita, Melina Mottin, Rafaela S. Fernandes, Lucca R. Policastro, Andre S. Godoy, Igor A. Santos, Uriel E. A. Ruiz, Icaro P. Caruso, Bruna K. P. Sousa, Ana C. G. Jardim, Fabio C. L. Almeida, Laura H. V. G. Gil, Carolina H. Andrade, Glaucius Oliva   +16 more
doaj   +2 more sources

Increased number of cases of Chikungunya virus (CHIKV) infection imported from the Caribbean and Central America to northern Italy, 2014 [PDF]

Epidemiology and Infection, 2016
SUMMARYThis report describes an increased number of cases of Chikungunya virus (CHIKV) infection imported in northern Italy (Emilia-Romagna region) during the period May–September 2014, indicating that the recent spread of CHIKV and its establishment in the Caribbean and in central America, resulted in a high number of imported cases in Europe, thus ...
Giada Rossini, Paolo Gaibani, Caterina Vocale, A C Finarelli, M.P. Landini   +4 more
openalex   +3 more sources

Chikungunya virus infection: molecular biology, clinical characteristics, and epidemiology in Asian countries

Journal of Biomedical Science, 2021
Chikungunya virus (CHIKV) is a re-emerging mosquito-borne human pathogen that causes chikungunya fever, which is typically accompanied by severe joint pain. In Asia, serological evidence indicated that CHIKV first emerged in 1954. From the 1950’s to 2005,
Sarawut Khongwichit, Jira Chansaenroj, Chintana Chirathaworn, Yong Poovorawan   +3 more
doaj   +2 more sources

Molecular surveillance of Dengue Virus (DENV) and its co-infection with Chikungunya Virus (CHIKV) among febrile patients: A comparative study from South Delhi, India

Virology Reports, 2021
AbstractConcomitant circulation of dengue and chikungunya viruses has been sporadically reported and needs to be individually diagnosed. Several sensitive molecular diagnostics are currently deployed for the diagnosis of both DENV and CHIKV, it is very difficult to delineate the two viral infections based on symptomology, as both share similar clinical
Rohit Sagar, Siva Raghavendhar, Kaustuv Nayak, Vineet Jain, Anmol Chandele, Ashok Kumar Patel, Kamal Kumar Gupta, Kaja Murali‐Krishna, Pratima Ray, Neera Kapoor   +9 more
openalex   +3 more sources

Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2α phosphorylation [PDF]

Virology Journal, 2013
Abstract Chikungunya (CHIKV) and Sindbis (SINV) are arboviruses belonging to the alphavirus genus within the Togaviridae family. They cause frequent epidemics of febrile illness and long-term arthralgic sequelae that affect millions of people each year.
Abhay P. S. Rathore, Mah Lee Ng, Subhash G. Vasudevan   +2 more
openalex   +4 more sources

Global Proteome Analysis of a Three-Dimensional Human Chondrocyte Cell Culture System Infected with Chikungunya Virus (CHIKV) Reveals Distinct Immune and Inflammatory Signatures. [PDF]

ACS Omega
Hasan A, Sharma G, Majumder N, Chaudhary S, Mehta D, Vaishya R, Ghosh S, Sunil S.   +7 more
europepmc   +4 more sources

Transcriptome analysis of human macrophages upon chikungunya virus (CHIKV) infection reveals regulation of distinct signaling and metabolic pathways during the early and late stages of infection. [PDF]

Heliyon, 2023
Srivastava P, Chaudhary S, Malhotra S, Varma B, Sunil S.   +4 more
europepmc   +3 more sources

Diagnosing the Outbreak and Spread of the Chikungunya Virus in Central & South America - The DARPA CHIKV Challenge

Journal of Clinical and Biomedical Advances, 2023
In 2014, the U.S. Defense Advanced Research Projects Agency (DARPA) issued a “challenge” to forecast the future outbreaks and spreads of the virus Chikungunya Virus (CHIKV) in Central and South America. We took on the challenge of predicting the cumulative number of Pacific Atlantic Health Organization (PAHO) reported Chikungunya or CHIKV cases by ...
Leonard J Pietrafesa
openalex   +2 more sources

Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo

Antiviral Research, 2014
The global emergence of Chikungunya virus (CHIKV) infection is alarming and currently there is no licensed vaccine or antiviral treatment available to mitigate this disease. CHIKV infection typically results in high viral load with an outcome of high fever, skin rashes, muscle pain, and sequelae of prolonged arthritis, which occurs in >90% of the ...
Abhay P. S. Rathore, Timothy Haystead, Pratyush Kumar Das, Andres Merits, Mah Lee Ng, Subhash G. Vasudevan   +5 more
openalex   +4 more sources

Whole-Genome sequencing of Chikungunya Virus (CHIKV) from Pakistan: Detection of the East/Central/South African (ECSA) genotype during the 2024 outbreak in Mansehra. [PDF]

PLoS One
Umair M, Yasir M, Jamal Z, Hakim R, Saeed SY, Salman M, Iqbal A, Khan MQ, Khanzada F, Javed Y.   +9 more
europepmc   +3 more sources