Results 291 to 300 of about 311,648 (345)

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Chimeric Protein Treatment of Pierce Disease

, 2020
openaire   +2 more sources

Effects of Cellulase and Lactobacillus plantarum Supplementation on Fermentation Characteristics, In Situ Degradability, and Microbial Community Dynamics of Apple Pomace Silage

Animal Research and One Health, EarlyView.
This study aimed to investigate the effects of cellulase and Lactobacillus plantarum on the silage quality, in situ digestibility, and microbial communities of apple pomace silage. The combined supplementation of cellulase and Lactobacillus plantarum in apple pomace silage improved fermentation quality and enhanced rumen utilization efficiency.
Zhuangzhuang Liu, Xiongfei Zhang, Fengbo Sun, Junhu Yao, Xinjian Lei   +4 more
wiley   +1 more source

Immunogenicity analyses and indirect ELISA application of a chimeric virus-like particle presenting a highly conserved peptide of Akabane virus Gc protein

Jingjing Wang, Fang Wei, Ruyang Yu, Dongjie Chen, Shaoqiang Wu   +4 more
openalex   +1 more source

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Ocular distribution of the chimeric protein IL2-PE40

Current Eye Research, 1995
A construct of IL-2 and pseudomonas exotoxin (PE40) has been genetically engineered. An aliquot of 100 microliter of the chimeric protein, radiolabelled with I125, was administered to healthy rats by various routes. At different intervals, ocular and non ocular tissues were removed and the levels of the radiolabelled chimeric protein IL-2-PE40 measured.
Haya Lorberboum-Galski
exaly   +3 more sources

Chimeric Protein Switch Biosensors

2023
Rapid detection of protein and small-molecule analytes is a valuable technique across multiple disciplines, but most in vitro testing of biological or environmental samples requires long, laborious processes and trained personnel in laboratory settings, leading to long wait times for results and high expenses.
Emma, Campbell, Timothy, Luxton, Declan, Kohl, Sarah A, Goodchild, Christoph, Walti, Lars J C, Jeuken   +5 more
openaire   +2 more sources

Prediction of Chimeric Protein Fold.

Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms, 2012
We propose two computational methods for predicting if a protein produced by fusion of genes will conserve the structures of the fused proteins. We use two complementary paths for prediction. The former is a simulation from the sequence while the latter exploits its expected structure. Early stages of protein folding are simulated from their amino acid
Acuña, Ruben, Lacroix, Zoé, Hadji, Fayez, Chomilier, Jacques, Papandreou, Nikolaos   +4 more
openaire   +3 more sources

Chimeric Proteins

2003
Most conventional vaccines consist of killed organisms or purified antigemc components of pathogens. However, this approach of vaccine development has several limitations. Large-scale growth of pathogens may be difficult to achieve and is not completely free of risk.
R, Janssen, J, Tommassen
openaire   +2 more sources

Chimeric Protein Engineering

International Journal of Peptide Research and Therapeutics, 2007
Protein stability can be enhanced by the incorporation of non-natural amino acids and semi-rigid peptidomimetics to lower the entropic penalty upon protein folding through preorganization. An example is the incorporation of aminoisobutyric acid (Aib, α-methylalanine) into proteins to restrict the Φ and Ψ backbone angles adjacent to Aib to those ...
Jianwen A. Feng, Lee A. Tessler, Garland R. Marshall   +2 more
openaire   +1 more source

Chloroplast import characteristics of chimeric proteins

Plant Molecular Biology, 1989
We have examined the import of a series of chimeric precursor proteins into chloroplasts. These fusion proteins contained the transit peptide, and various amounts of the amino-terminal region of the mature peptide, from the small subunit of ribulose 1,5-bisphosphate carboxylase, linked to the coat protein of brome mosaic virus.
T H, Lubben, A A, Gatenby, P, Ahlquist, K, Keegstra   +3 more
openaire   +2 more sources