Results 91 to 100 of about 254,758 (298)

Human and bovine respiratory syncytial virus vaccine research and development [PDF]

, 2008
Human (HRSV) and bovine (BRSV) respiratory syncytial viruses (RSV) are two closely related viruses, which are the most important causative agents of respiratory tract infections of young children and calves, respectively.
Deplanche, Martine, Meyer, Gilles, Schelcher, François   +2 more
core   +2 more sources

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Immunological properties of a chimeric protein containing the major capsid protein of echovirus 30 (Picornaviridae: Enterovirus: Enterovirus betacoxsackie)

Вопросы вирусологии
Introduction. Enterovirus infection, widespread in the world and in Russia, is characterized by a variety of clinical forms, one of which is serous meningitis. The most common cause of enterovirus meningitis in children is echovirus 30 (E30). Previously,
Dmitry A. Melentev, Dmitry V. Novikov, Ekaterina V. Mokhonova, Nadezhda A. Novikova, Alexander Yu. Kashnikov, Svetlana G. Selivanova, Lyudmila N. Golitsyna, Vladislav A. Lapin, Maria I. Tsyganova, Dmitry E. Zaitsev, Viktor V. Novikov   +10 more
doaj   +1 more source

Anti‐CD19 CAR T Cells in Autoimmune Encephalitis: Inflammation Controlled, Neurodegeneration Unchecked?

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos, Marwa Al‐Dubai, Denise Walther, Dominic Borie, Jan D. Lünemann, Marc Pawlitzki, Sven G. Meuth, Solveig Henneicke, Stefan Vielhaber, Stefanie Schreiber   +9 more
wiley   +1 more source

Uncovering the expression patterns of chimeric transcripts using surveys of affymetrix GeneChips. [PDF]

, 2010
BACKGROUND: A chimeric transcript is a single RNA sequence which results from the transcription of two adjacent genes. Recent studies estimate that at least 4% of tandem human gene pairs may form chimeric transcripts. Affymetrix GeneChip data are used to
da Silva Camargo, R, Harrison, AP, Langdon, WB, Rowsell, J, Stalteri, MA   +4 more
core   +2 more sources

Rheumatologic Manifestations of Patients With Type B Insulin Resistance

Arthritis Care &Research, EarlyView.
Objective The objectives of this study were to identify laboratory and clinical features associated with type B insulin resistance (TBIR), a rare condition caused by autoantibodies that inhibit the insulin receptor, most frequently occurring in the setting of systemic lupus erythematosus (SLE), and to increase awareness of this rare, life‐threatening ...
S. Amara Ogbonnaya, Sandra G. Williams, Raphael A. Kirou, Marissa Lightbourne, Rebecca J. Brown   +4 more
wiley   +1 more source

Application of crossflow ultrafiltration for scaling up the purification of a recombinant ferritin [PDF]

, 2019
Ferritin proteins are taking center stage as smart nanocarriers for drug delivery due to their hollow cage-like structures and their unique 24-meric assembly.
Boffi, A., Bonamore, A., Ghirga, F., Macone, A., Palombarini, F.   +4 more
core   +1 more source

Chimeric relaxase-cas protein

, 2021
ABSTRACT: The present invention relates to: the fusion protein relaxase-Cas12a; the CRISPR/Cas system that the fusion protein comprises; and the use of the relaxase-Cas12a fusion protein and/or CRISPR/Cas system to translocate to target cells, by means of the bacterial type IV secretion system, endonucleases and/or endonucleases bonded to DNA molecules,
Llosa Blas, Matxalen, Guzmán Herrador, Dolores Lucía, Bikard, David   +2 more
openaire   +1 more source

An Engineered Living Material With Pro‐Angiogenic Activity Inducible by Near‐Infrared Light

Advanced Functional Materials, EarlyView.
NIR‐responsive engineered living materials (ELMs) for controlled angiogenesis: Near‐infrared (800 nm) light activates engineered probiotic bacteria within alginate‐based living materials to secrete a blood vessel‐regenerating protein. The released protein promotes pro‐angiogenic effects in endothelial networks and chick chorioallantoic membranes.
Anwesha Chatterjee, Stefanie S. M. Meier, Sara Trujillo, Andreas Möglich, Shrikrishnan Sankaran   +4 more
wiley   +1 more source

Immunomodulation in Experimental and Clinical Nephrology Using Chimeric Proteins

Kidney and Blood Pressure Research, 1996
The objective of immunosuppressive therapy in nephrology is to prevent autoimmune diseases and to suppress kidney allograft rejections while sparing other effects. Increased clarification of the underlying immune mechanism has made specific immunodulation possible using chimeric proteins in which the variable domains of an immunoglobulin are replaced ...
Kunzendorf, U, Pohl, T, Bulfone-Paus, S, Krause, H, Ziegler, E, Onu, A, Distler, A   +6 more
openaire   +3 more sources