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Utilizing Chimeric Proteins for Exploring the Cellular Fate of Endogenous Proteins
Biochemical and Biophysical Research Communications, 2002We recently designed and constructed chimeric proteins for the elimination of specific cell populations. These chimeric proteins are composed of a targeting component fused to an apoptotic protein as the killing moiety. However, chimeric proteins can serve not only to eliminate cell populations, but also as "biological tools" for studying the fate of ...
Rami Aqeilan, Haya Lorberboum-Galski
exaly +3 more sources
Chimeric Protein Switch Biosensors
2023Rapid detection of protein and small-molecule analytes is a valuable technique across multiple disciplines, but most in vitro testing of biological or environmental samples requires long, laborious processes and trained personnel in laboratory settings, leading to long wait times for results and high expenses.
Emma, Campbell +5 more
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Prediction of Chimeric Protein Fold.
Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms, 2012We propose two computational methods for predicting if a protein produced by fusion of genes will conserve the structures of the fused proteins. We use two complementary paths for prediction. The former is a simulation from the sequence while the latter exploits its expected structure. Early stages of protein folding are simulated from their amino acid
Acuña, Ruben +4 more
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2003
Most conventional vaccines consist of killed organisms or purified antigemc components of pathogens. However, this approach of vaccine development has several limitations. Large-scale growth of pathogens may be difficult to achieve and is not completely free of risk.
R, Janssen, J, Tommassen
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Most conventional vaccines consist of killed organisms or purified antigemc components of pathogens. However, this approach of vaccine development has several limitations. Large-scale growth of pathogens may be difficult to achieve and is not completely free of risk.
R, Janssen, J, Tommassen
openaire +2 more sources
International Journal of Peptide Research and Therapeutics, 2007
Protein stability can be enhanced by the incorporation of non-natural amino acids and semi-rigid peptidomimetics to lower the entropic penalty upon protein folding through preorganization. An example is the incorporation of aminoisobutyric acid (Aib, α-methylalanine) into proteins to restrict the Φ and Ψ backbone angles adjacent to Aib to those ...
Jianwen A. Feng +2 more
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Protein stability can be enhanced by the incorporation of non-natural amino acids and semi-rigid peptidomimetics to lower the entropic penalty upon protein folding through preorganization. An example is the incorporation of aminoisobutyric acid (Aib, α-methylalanine) into proteins to restrict the Φ and Ψ backbone angles adjacent to Aib to those ...
Jianwen A. Feng +2 more
openaire +1 more source
Chloroplast import characteristics of chimeric proteins
Plant Molecular Biology, 1989We have examined the import of a series of chimeric precursor proteins into chloroplasts. These fusion proteins contained the transit peptide, and various amounts of the amino-terminal region of the mature peptide, from the small subunit of ribulose 1,5-bisphosphate carboxylase, linked to the coat protein of brome mosaic virus.
T H, Lubben +3 more
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Striking gold with chimeric proteins
Nature Catalysis, 2021The ability to control the subtle differences in reaction mechanisms and outcomes is an aspiration of many synthetic chemists. Now protein evolution has enabled the control of selectivity for hydroamination reactions catalysed by gold-based artificial metalloenzymes by favouring dual-gold catalysis over monomeric catalysis.
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ACS Synthetic Biology, 2014
Bacterial microcompartments (BMCs) are self-assembling organelles composed entirely of protein. Depending on the enzymes they encapsulate, BMCs function in either inorganic carbon fixation (carboxysomes) or organic carbon utilization (metabolosomes).
Fei, Cai +4 more
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Bacterial microcompartments (BMCs) are self-assembling organelles composed entirely of protein. Depending on the enzymes they encapsulate, BMCs function in either inorganic carbon fixation (carboxysomes) or organic carbon utilization (metabolosomes).
Fei, Cai +4 more
openaire +2 more sources
Fungal Protein Production: Design and Production of Chimeric Proteins
Annual Review of Microbiology, 2011For more than a century, filamentous fungi have been used for the production of a wide variety of endogenous enzymes of industrial interest. More recently, with the use of genetic engineering tools developed for these organisms, this use has expanded for the production of nonnative heterologous proteins.
Punt, Peter J. +4 more
openaire +5 more sources